DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Ppp1r12b

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_006529770.1	Gene:	Ppp1r12b / 329251	MGIID:	1916417	Length:	1053	Species:	Mus musculus

Alignment Length:	852	Identity:	169/852 - (19%)
Similarity:	289/852 - (33%)	Gaps:	202/852 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  4802 TPSSASLETTVP---SVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTT 4863
            ||..|:....|.   |:..|...::.|.:..||       :|.:|.....||...:..:..| ..
Mouse   252 TPLHAAAHWGVKEACSILAEALCDMDIRNKLGQ-------TPFDVADEGLVEHLEMLQKKQD-VL 308

  Fly  4864 PSESPETPTTLPSDFITR------------------PHSEKTTESTRDVPTTRPFEASTPSSASL 4910
            .||.......:.||..::                  |.|:.|.|..::          :.||:|.
Mouse   309 RSEKETRNKLIESDLNSKFQSGLFKNKEKMLYEEEIPKSQDTEEENKE----------SSSSSSE 363

  Fly  4911 ETTVPSVTLETTTNVPIGSTGGQVTEQTTS-SPSEVRTTIRVEESTLPSRSTDRTT--------- 4965
            |........|:.|.    ....:..|.|.: |.||:::.| :|:...|:::|...:
Mouse   364 EEEGEDEVSESETE----KEADKKPEATVNHSNSEIKSRI-MEQIPAPAQNTFSASSARRLSSLF 423

  Fly  4966 -PSESPETPTTLPSDF-----TTRPHS-----EQTTESTRDVPTTRPFEASTPSPASLETTVPSV 5019
             .:|.|:..:  ||.:     .|..|:     ..:.|:.||..::....:|:|..::|   :...
Mouse   424 NKAEEPKDES--PSSWRLGLRKTGSHNMLSEVANSREALRDRGSSIYRSSSSPRISAL---LDDK 483

  Fly  5020 TLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRT-----TPSESPETPTTLP 5079
            ..|....    |....:..:..||.|::......|.:....||...|     ..::..|||.|:.
Mouse   484 DKERENK----SYFSMLVPRRLSSTSDIEEKENRESAVNLVRSGSHTRQLWRDEAKGSETPQTIA 544

  Fly  5080 SDFITRTYSDQTTESTRDVPTTRPFEAS-TPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTT 5143
            ....|.||....:......||:....|: ..|||:...|:.|.||..:...|..|....|:..|.
Mouse   545 PSTYTSTYLKSASFGKSSDPTSPYISANRNSSPATSPITIGSSTSRGSQWQPASSCPAPVSTNTP 609

  Fly  5144 APPSEFRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEA 5208
            ||....||..:.:..:    :.::|..|.|..||..                    |.|.||
Mouse   610 APVQHVRTPYKSQADS----TAEKTADSVSSSTPLC--------------------VITNRP--- 647

  Fly  5209 STPSPASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPS 5273
             .||.|:   .||:.|:       ..|.|...:.:.........|.:|.||:....::..|
Mouse   648 -APSTAN---GVPAATV-------FSSAGTDPSVEAREKRRSYLTPVRDEEAESLRKARSR---- 697

  Fly  5274 ESPETPTLPSDFTTRPHSEQTTESTRDVPATRPFEA-STPSPASLETTVPSVTSEATTNVPIGST 5337
                            .:.||..||:.|..|...|| .|.|.:..|........|...: |.|..
Mouse   698 ----------------QARQTRRSTQGVTLTDLQEAEKTFSRSRAERQAQEQPGEKLED-PGGLE 745

  Fly  5338 GGQVTEQTTSSPS----EVRTTIRVEESTLPSRSTDRTSPSESPETPTTLPSDFTTRPHSDQTTE 5398
            |....::.:::|:    |.|:   :||..:..|....|    .|:.|||..|...:||.....:.
Mouse   746 GSTKKQEPSAAPTKGAGEGRS---LEEEPIYHRLRYPT----QPDKPTTPVSPSASRPSLYTGSH 803

  Fly  5399 CTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEES 5463
            ..|   |:|   ||.|.|.:.||:..:...:   .:.....|....:..:|:...||...|.::.
Mouse   804 LLR---TSR---ASGPDSENSETSTHATAAK---EMDTSEKGEADLDDQSSNRLSVRERRRAKDR 859

  Fly  5464 ------TLPSRSADRTTPSESPE---------------TPTLPSDFTTRPHSEQTTE-------- 5499
                  ...:...|.|..||..:               .||....::.|..:....|
Mouse   860 RRGTGINFWTNDEDETDVSEEVKEALHERLSRLESGGTNPTSSDSYSDRASARARREAREARLAS 924

  Fly  5500 --------STRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEFR 5556
                    |.||.  .:.:|::...:..|:|.:....||.   ..|.:...::.:|.....|:..
Mouse   925 LTSRVEEDSNRDY--KKLYESALTENQKLKTKLQEAQLEL---ADIKAKLEKMAQQKQEKTSDRS 984

  Fly  5557 TTIRVEE 5563
            :.:.||:
Mouse   985 SVLEVEK 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572	11/47 (23%)
		DUF4758	4785..4964	CDD:292572	37/183 (20%)
		DUF4696	4841..5385	CDD:292395	121/593 (20%)
		DUF4758	4887..5098	CDD:292572	45/236 (19%)
		DUF4758	5193..5371	CDD:292572	38/182 (21%)
		DUF4758	5294..5487	CDD:292572	48/218 (22%)
		DUF4758	5445..5650	CDD:292572	25/156 (16%)
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Ppp1r12b	XP_006529770.1	PHA03095	61..>290	CDD:222980	10/44 (23%)
		Ank_2	65..154	CDD:372319
		ANK repeat	90..121	CDD:293786
		ANK repeat	123..154	CDD:293786
		ANK repeat	156..247	CDD:293786
		ANK repeat	249..280	CDD:293786	7/27 (26%)
		Hamartin	<530..849	CDD:367919	87/393 (22%)
		DUF5585	535..>672	CDD:375359	42/174 (24%)
		PRKG1_interact	936..1042	CDD:374206	11/61 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910