DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and dy

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_511130.2	Gene:	dy / 32130	FlyBaseID:	FBgn0004511	Length:	699	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	108/477 - (22%)
Similarity:	179/477 - (37%)	Gaps:	141/477 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly 22566 DFPR-PDMVVSCLADGVQVEIHITEPGFNGVLYVKGHSKDEECRRVVNLAGETVPRTEIFRVHFG 22629
            |.|: ..:.|.|..:|::|.:...:| |||:::.|||..:..|   |:|.......:..|.:...
  Fly   244 DMPKIVSLDVKCEKNGMKVFVQFDKP-FNGIVFSKGHYSNMNC---VHLPSGLGRSSASFDIGLH 304

  Fly 22630 SCGMQAVKD--------------VASF---VLVIQKHPKLVTYKAQAYNIKCVYQTG-EKNVTL- 22675
            .||.....|              ..::   ::|||..|::.....||..::|.:... ||:||.
  Fly   305 ECGTAGNTDNYGQGYGHEAGSTGAGTYFENIIVIQYDPQVQEVWDQARKLRCTWHDQYEKSVTFR 369

  Fly 22676 GFNVSMLTT-----AGTIANTGPPPICQMRIITNEG---EEINS-AEIGDNLKLQVDV-EPATIY 22730
            .|.|.||..     ||.  |.|    |.|:|...:|   .|::. .:||..:.:.:.: :..:.:
  Fly   370 PFPVDMLDVVRADFAGD--NVG----CWMQIQVGKGPWASEVSGLVKIGQTMTMVLAIKDDDSKF 428

  Fly 22731 GGFARSCIAKTMEDNVQNEYLVTDENGCATDTSIFGNW----EYNPDTNSL-LASFNAFKFPSSD 22790
            ....|:|:|   .|..:....:.|:.||.|...:...:    .:....:.| .|.|.|||||.|.
  Fly   429 DMLVRNCVA---HDGKRAPIQLVDQRGCVTRPKLMSRFTKIKNFGASASVLSYAHFQAFKFPDSM 490

  Fly 22791 NIRFQCNIRVCFGRCQPVNCGG-------------------------------YNAFGRRR---- 22820
            .:.|||.|::|...| |..|..                               .:|.|:||
  Fly   491 EVHFQCTIQICRYHC-PEQCSAETNLQDVHHLQVGPESQYGPPPQLHVDAYHVASAIGKRRDERR 554

  Fly 22821 -----RSIADNSTDATAIATNSGVEGQLREEITISSNAILTF---EKRSGQG--LNDAN--IKPA 22873
                 |::|:.......|             |.:.|:..|||   ::..|.|  .|.||  :..:
  Fly   555 VQRRARAVAEPQVGLNRI-------------IKVVSSGDLTFAIDDQAGGNGSSTNGANSGVDRS 606

  Fly 22874 AQ------RVED-ICVSMVGLIIALVITALLALVAVAVAVSCWLMAYRRRP----------KTIA 22921
            .|      |.|. ||::..|..|.|::  ||.::..:...|. ::..|.||          :.:|
  Fly   607 PQTMVFPLREEGLICMTTPGFAITLIV--LLGILVTSCLTSA-VLYVRLRPFSSFAGSAKERAVA 668

  Fly 22922 PLPHPPEFPNPLFSNPDAVPEP 22943
                        |:||...|.|
  Fly   669 ------------FTNPQLAPLP 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579	67/268 (25%)
		Zona_pellucida	<22714..22810	CDD:278526	26/101 (26%)
dy	NP_511130.2	ZP	254..513	CDD:214579	68/272 (25%)
dy	NP_511130.2	Zona_pellucida	<403..510	CDD:278526	27/110 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910