DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and CG2145

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001285102.1	Gene:	CG2145 / 32027	FlyBaseID:	FBgn0030251	Length:	592	Species:	Drosophila melanogaster

Alignment Length:	624	Identity:	136/624 - (21%)
Similarity:	189/624 - (30%)	Gaps:	219/624 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  7393 TPSPASLETTVPSVTLETTTSVP---------MGSTGGQVTGQTTAPPSEVRTTIRVEESTLPSR 7448
            ||.|..        .:||||...         .||.|...|..|.|||     .:...:|.:.:.
  Fly    32 TPDPLD--------AVETTTKKSSWFGGFKKFFGSDGTTTTTSTIAPP-----VVTSPKSVVVTP 83

  Fly  7449 STDRTPP----SESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFESSTPRPVTLEIAVPPVT 7509
            :....||    |.:|..|      ...||          |.|.:.||.:| ..|.|     ||
  Fly    84 TAANKPPPLVISHAPLMP------LGPRP----------DTPGSSPFGAS-QNPQT-----PP-- 124

  Fly  7510 SETTTNVPIGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTTPSESPETPTTLPSDFTTR 7574
                          |....|.||||.            ||:.:.   ||:.|    .||...:.|
  Fly   125 --------------QWPSSTRATPSH------------PSQPSQ---PSQQP----PLPGFASYR 156

  Fly  7575 PHSDQTTESTRDVPTTRPFEAS---TPSPASLETTVP-------SVTLETTTNVPIGSTGGQVTG 7629
            |..          |....::.|   .|.||...|..|       |.|..|||..||.||.|:...
  Fly   157 PQK----------PQPNSYDLSYGGGPQPAPAGTGRPGFGLGISSTTSTTTTAKPITSTTGKTPQ 211

  Fly  7630 QT---TATPSEVRTTIGVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPT 7691
            |.   .|.|...|.:...:...||:..|...:|:.:|.:|:...|...|..|...        |.
  Fly   212 QKEDFPALPGPRRPSQKEDFPALPAPKTPPGSPTPTPGSPSAWQSPLPTPQHPVH--------PP 268

  Fly  7692 TRPFEASTPRPVTLETAVPSVTSETTTNVPIGSTVTSE----------TTTNVPIGSTGGQVAGQ 7746
            |:...|:||.|    |..||.:|..|.....||:|...          |||..|    |.|.:|.
  Fly   269 TKATSAATPTP----TPTPSFSSSVTPTPAHGSSVGPHKDGGGGGGGGTTTVRP----GFQSSGN 325

  Fly  7747 TTAPPSEVR-----------------TTIRVEESTLPSRSADR------TTPSESPETPTTLPSD 7788
            :.|...|:|                 ..:.::..|....|||.      |..|::.|:||.:...
  Fly   326 SVATDDEIRQLTELLYTKESNSQIGNIQVNLQGRTRSIDSADEAPNPLLTVDSKALESPTIVKMR 390

  Fly  7789 FTTRPHSEQTTESTRDVPTTRPFE------------------------ASTPSPASLETTVPSV- 7828
            .....:...|..:....|..|..|                        ..:|.|.:....|..:
  Fly   391 LLFNNYEHDTHVNEHVTPNERKEENDFLDAVMATPVMRQAMLFLQQKGVVSPDPKTHRDLVKELW 455

  Fly  7829 -TSETTTNVPIGSTG-----------------------------------GQLTEQSTSSPSEVR 7857
             |..:.....|||:|                                   |.:.||...:..::
  Fly   456 FTQYSRGQGKIGSSGFEHVFVYEVKDGTIIGFHNWVYIGDEEKDGRFDYKGYMKEQDIGTKGKI- 519

  Fly  7858 TTIRVEESTLPSRSTDRTFPSESPEKPTTLPS-DFTTRP 7895
            ..||.....| ::..:..|...|||....|.: .|..||
  Fly   520 VKIRFSHQGL-NKPVNTVFVGTSPELELALYTVCFQLRP 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395	44/188 (23%)
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395	136/624 (22%)
		DUF4758	7400..7587	CDD:292572	44/199 (22%)
		DUF4758	7538..7707	CDD:292572	45/181 (25%)
		DUF4758	7798..7979	CDD:292572	26/160 (16%)
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
CG2145	NP_001285102.1	XendoU	330..590	CDD:286496	37/230 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910