DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and CG32373

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001261534.1	Gene:	CG32373 / 318000	FlyBaseID:	FBgn0052373	Length:	486	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	125/554 - (22%)
Similarity:	180/554 - (32%)	Gaps:	206/554 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NLRANSRFR--GE-VFYLNLENGYFGCQVNESTEYLQLFNLSKLCDGTQDCFLGADELSKELKCT 94
            |.:|:.:.|  || ||.:.    |:.|:||        :.|.:..|..             |.|:
  Fly    56 NAKASVKLRRNGEHVFLVT----YYSCRVN--------YKLKRAKDNA-------------LYCS 95

  Fly    95 N--------DCDKDGTKCTHGACLNGVCHCNDGYGGCNCVDKDENECKQRPCDVFAHCTNTLGSF 151
            |        :|.|.|...|| :.......|....|||
  Fly    96 NGIWLGLKPNCIKIGKGNTH-SMKQKKMRCRIDNGGC---------------------------- 131

  Fly   152 TCTCFPGYRGNGFHCEDIDECQDPAIAARCVENAECCNLPAHFLCKCKDGYEGDGEVL--CTDVD 214
                                             |..||...| .|:|.:||..:...|  |.|:|
  Fly   132 ---------------------------------AHICNRSTH-KCECYEGYTLNSTDLRSCNDID 162

  Fly   215 ECRNPENCGPNALCTNTPGNYTCSCPDGYVGNNPYREGCQDVDECSYPNV---CGPGAICTNLEG 276
            ||:. .|.|.:.:|.|.||.:.|:|..|:..:....:.|.|:|||:.|.:   |..|  |.||.|
  Fly   163 ECKE-SNGGCSQVCNNLPGEFICTCNSGFEIDESDEKTCLDIDECADPELSWDCTAG--CKNLNG 224

  Fly   277 SYRCDCPPGY-------DGDGRSESGCVDQDECARTPCGRNADCLNTDGSFRCLCPDGYS-GDPM 333
            :|:  |.|..       ||||.|....|                          |..|:. .|..
  Fly   225 TYK--CLPSLVGRVEPTDGDGFSPGEIV--------------------------CKSGFKLSDDG 261

  Fly   334 NGCEDVDEC-----------ATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPHA-----DQLPQ 382
            :.|:|::||           .|...|  ..:|.|..||:.|.||.|:.|..|.::     .:||
  Fly   262 SECQDINECDLADIDSDSWRMTYRYC--EHKCENTVGSYICHCPQGYHLLDDQNSCILDGSKLP- 323

  Fly   383 PLNTQQLGYGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSY-RC--LCP 444
            |.....:.......||.|..:....|.|..|                 |.:....:| ||  .|.
  Fly   324 PSKDAPVSQEAPRKDICPLFKGPANGKASCD-----------------KYLQNGFNYTRCNITCN 371

  Fly   445 SGFQGQGYLHCENINECQDNPCGENAICTD----TVGSFVCTCKPDYTGDPFRGCVDIDECTALD 505
            :|:..||         .|...||...:.:.    .|.|...:| |..| .|..|......|.  :
  Fly   372 AGYIMQG---------SQFAVCGHTGLWSSPEAKCVESLALSC-PVLT-PPRNGRFYPASCN--N 423

  Fly   506 KPCGQHAVCENTVPGYNCKCPQGYDGKPDPKVAC 539
            :|....|:||       ..|.:||..:.|.::.|
  Fly   424 EPSKSLAICE-------LLCDRGYLPRMDTQLIC 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699	0/28 (0%)
		EGF_CA	212..247	CDD:238011	13/34 (38%)
		EGF_CA	255..>286	CDD:214542	14/33 (42%)
		EGF_CA	298..331	CDD:238011	2/33 (6%)
		EGF_CA	338..373	CDD:238011	14/45 (31%)
		EGF_CA	413..456	CDD:238011	9/45 (20%)
		EGF_CA	457..490	CDD:238011	8/36 (22%)
		EGF_CA	497..>529	CDD:214542	6/31 (19%)
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
CG32373	NP_001261534.1	FXa_inhibition	124..158	CDD:291342	13/95 (14%)
		vWFA	<158..199	CDD:294047	14/41 (34%)
		FXa_inhibition	287..315	CDD:291342	11/29 (38%)
		CCP	340..398	CDD:153056	15/83 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA2W
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900