DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Col6a6

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_038938536.1	Gene:	Col6a6 / 315979	RGDID:	1309172	Length:	2264	Species:	Rattus norvegicus

Alignment Length:	599	Identity:	127/599 - (21%)
Similarity:	176/599 - (29%)	Gaps:	257/599 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly  8582 VCINSNHAADCS-CADGFQ---GNGF-------VGCQPARSHVCQYNEDCPPTKLCDRLNRRCIN 8635
            :.|..:.|||.| .||...   |.||       :|.....||                |:::.||
  Rat  1328 ITIAVDGAADSSDLADLLYIEFGKGFEYRTQFTIGMGNLGSH----------------LSKQLIN 1376

  Fly  8636 PCQEDSCGENAECIPVNHGTECRCL-----------------PGFLGN-AYV------------- 8669
            ..:...|     |:      .|:|.                 |||.|: .|:
  Rat  1377 VAERTCC-----CL------LCKCTGWDGAMGDPGSAGEKGPPGFKGSEGYLGEEGIAGERGALG 1430

  Fly  8670 --------QCLPSQGCR-----SDSECDSSQACINGKCSSPCQCGAYALCDVVNHRGVCKCPPGY 8721
                    .||.::|.:     |..|.:..:..::|........|      :...||. :...|.
  Rat  1431 PMGEQGTKGCLGAKGPKGARGLSGEEGEVGEDGLDGLNGEQGDSG------IPGRRGE-RGDAGS 1488

  Fly  8722 NGNP-KVGCSPPQDPCDPNPCGLNALCELDNGNP----ICYCPKGLTGNPFKNCIPEGDECTPNP 8781
            .|:| |.|.|.     |..|.||..    |.|.|    ....||||.|:|.:    :|....|..
  Rat  1489 QGSPGKRGASG-----DRGPKGLRG----DPGTPGRDNSIQGPKGLKGDPGR----QGRRGWPGS 1540

  Fly  8782 CGPNSGCRR---VGG-----NPVCFCLPEYEGQPP-SIPCELPSNPCDPSPCGPNTQCSVL--SN 8835
            .| ..|.||   |.|     .|        :|.|. :.|..|..:|....|.||..:....  ..
  Rat  1541 PG-TPGSRRKMVVHGRRGHTGP--------QGNPGITGPDGLEGSPGLKGPQGPRGEVGEKGEKG 1596

  Fly  8836 GFSKCTCLPNYVESPNTIRGCVEPINPCDPNPCGTGAICDSSRHPVCYCPDNKIGNPFRLCDKPA 8900
            ||                 |...|..|
  Rat  1597 GF-----------------GMKGPQGP-------------------------------------- 1606

  Fly  8901 VTIELCQPGPCGRNAECYVAGNREECYCRSGYVGDAYQGCREPSRTVCDPNPCGPNANCVVAGDG 8965
                   |||.||      |||:       |:.|.  ||.:.      :|...|........|
  Rat  1607 -------PGPKGR------AGNQ-------GHWGS--QGSKG------EPGDLGEKGAAGFPG-- 1641

  Fly  8966 QTACVCPDGLSGDPTS----VIGCHGYECQVDADCPNS---KACMGYRCYDP-CPGACG-QGAHC 9021
                  |.||.||..|    .||..|.:.|  ...|..   |..:|    || .||..| :||..
  Rat  1642 ------PRGLQGDDGSPGYGSIGRKGTKGQ--EGFPGESGPKGDIG----DPGDPGEAGPKGARG 1694

  Fly  9022 QVEEHHPVCSCNSGLTGNPGIRCYALDHPKKNPCVPSPCGRN--SECKLLNNRAVCSCIPGYLGD 9084
            :        :.::|:.|.||           :|..|.|.||.  ...:.|.:.:.|..|. |:.:
  Rat  1695 K--------TVSAGIPGEPG-----------SPGEPGPPGRKGMKGARGLASFSTCDLIQ-YVRE 1739

  Fly  9085 --PQSGCQPECDIN 9096
              |....:|||.::
  Rat  1740 HSPVRHGKPECPVH 1753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Col6a6	XP_038938536.1	vWFA	25..179	CDD:412136
		vWFA	227..392	CDD:412136
		VWA	435..604	CDD:395045
		VWA	621..789	CDD:395045
		VWA	808..980	CDD:395045
		VWA	999..1166	CDD:395045
		VWA	1186..1344	CDD:214621	6/15 (40%)
		Collagen	1394..1450	CDD:396114	8/55 (15%)
		Collagen	1481..1547	CDD:396114	24/80 (30%)
		Collagen	1521..1589	CDD:396114	23/80 (29%)
		Collagen	1638..1695	CDD:396114	21/70 (30%)
		VWA	1757..1921	CDD:395045
		vWFA_subfamily_ECM	1962..2140	CDD:238727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910