DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and CG3108

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_572262.1	Gene:	CG3108 / 31506	FlyBaseID:	FBgn0029807	Length:	1132	Species:	Drosophila melanogaster

Alignment Length:	766	Identity:	167/766 - (21%)
Similarity:	277/766 - (36%)	Gaps:	126/766 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  5162 SRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPAS------LETTV 5220
            |.|.||.. .|..|.|            :||..:..:||........|.||..|      :..||
  Fly    37 SMSLDRLA-LERNELP------------ADQQQQQQQDVLVDNMKLTSIPSADSSDMYMLVPDTV 88

  Fly  5221 PSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPS-RSADRTTPSESPETPT---- 5280
            .| .||.|.:|.                   |.:|..:..:.|| .|:......||..:|.
  Fly    89 AS-QLEDTEHVN-------------------RNSIEADPESDPSGSSSSDMLMLESDSSPAMQLV 133

  Fly  5281 -LPSDFT---TRPHSEQTTESTRDVPATRPFEASTPSPAS----LETTVPSVTSEATTNVPIGST 5337
             ||||.|   ::|.:|..||:.:..|.:.........|||    ||.||...|..|.  ||:...
  Fly   134 ELPSDITVAESQPETEHDTENDQQQPESIEEHVVLMKPASQEAQLEQTVDLATEAAP--VPLNDE 196

  Fly  5338 GGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTSPSESPETPTTL-PSDFTTRPHSDQTTECTR 5401
            ..:..|...::.|.|....:..|:.:     |...|.||...|..: |.::.:....:| .|...
  Fly   197 LPEDEESPAATESAVEELEKESEAAM-----DDQVPEESEIQPEQVQPGEYQSESDGEQ-AETKP 255

  Fly  5402 DVPTTRPFEASTPSSASLETTVPSVTLETTTNV---PIGSTGGQVTEQTTSSP-SEVRTTIRVEE 5462
            ::......||...:.|..|.. |.:.:|....|   |...:..:|..|....| |||.:....|.
  Fly   256 EIEAQPEVEAQPEAEAQPEAE-PQLEVEPQPEVESQPEVESQPEVEAQPEVEPQSEVESQPEAES 319

  Fly  5463 STLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSSASLETTVPSV 5527
            .:.|...|:   ....||..:|| :..::|.:|...|...:|      ||...|...::||..|:
  Fly   320 HSEPETQAE---VEAQPEVESLP-EAESQPEAESQPEREPEV------EAEKISDNEVDTTEASL 374

  Fly  5528 TLETTTNVPIGSTGGQ---VTEQTTSSPSEFRTTIRVEESTLPSRSA--DRTTPSESPETPTLPS 5587
            .......:..|.|...   |.|:...:..:..|.:..|:...|...|  ::..|....|....|.
  Fly   375 METLVEGIEDGLTAAMDNLVPEELAEASDKQETELESEDQQSPVTEAIEEQAVPEIEQEKEKEPE 439

  Fly  5588 DFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAP 5652
            ..|.   :::|.:.:.......|.|.:.......|.....:..|       |....:|..:..:.
  Fly   440 QITL---ADETEQDSAQPSNEEPVEIAPEQHTEAEIAPAKIPEE-------GKPEEEVQVEEESK 494

  Fly  5653 P---SEVRTTIRVEESTLPSRSTD---RTTPSESPETPTILPSDSTTRTYSDQTTESTRDVPTTR 5711
            |   |:....|:.:|...|.....   .|.|:.:...|...|:|......::...|...::|...
  Fly   495 PVEESKPEEEIKQQEDAKPEEDDQNYAETQPAVTEVKPEETPADIPVEIPAEVPAEIPAEIPAEV 559

  Fly  5712 PFEASTPSPASLETTVPS-VTLETTTNVPIGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTD 5775
            |.|....|||.:...||: :..|....:|            ..||:|....|..:   :|::..
  Fly   560 PAEIPAESPAEIAAEVPAEIPAEIPAEIP------------AETPAETHAEIPAD---VPAQVV- 608

  Fly  5776 RTSPSESP-ETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTN 5839
            ..:|:|:| |||..:|::..::...:..::||:..|.... ||..|.    :.|.|..:|..||.
  Fly   609 AEAPAETPAETPAEVPAEIPSKVQDEIQSDSTQAEPQVEK-EAQQPE----KETKPLESSLLTTI 668

  Fly  5840 VPIGSTGGQVTEQTTSSPSEVRTTI--GLEESTLPSRSTDRTSPSESPETP 5888
            :|:.....||..|    |.:|:.::  .:..|.:..:.::...|....|:|
  Fly   669 IPMVMPQPQVPSQ----PLQVQDSVLNYVNASFMQQQPSETDLPKTEEESP 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395	60/242 (25%)
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572	47/196 (24%)
		DUF4758	5294..5487	CDD:292572	47/201 (23%)
		DUF4758	5445..5650	CDD:292572	41/210 (20%)
		DUF4758	5700..5877	CDD:292572	41/180 (23%)
		DUF4696	5756..6396	CDD:292395	31/136 (23%)
		DUF4758	5802..5979	CDD:292572	21/89 (24%)
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
CG3108	NP_572262.1	Propep_M14	730..797	CDD:280416
CG3108	NP_572262.1	M14_CP_A-B_like	821..1112	CDD:199844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910