DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and N

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001245510.1 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster


Alignment Length:1943 Identity:521/1943 - (26%)
Similarity:728/1943 - (37%) Gaps:573/1943 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 CFLGADELSKELKCTNDCDKDGTKCTHGACLNG-----------VCHCNDGYGGCNCVDKDENEC 133
            |.||.||...|:...|.||       |..||||           .|.|.:||.|..|..|  |.|
  Fly   126 CPLGFDESLCEIAVPNACD-------HVTCLNGGTCQLKTLEEYTCACANGYTGERCETK--NLC 181

  Fly   134 KQRPCDVFAHCTNTLG--SFTCTCFPGYRGNGFHCE-DIDECQ-DPAIAARCVENAECCNLPAHF 194
            ...||...|.||...|  ||||:|.||:.|:  .|. ||:||| :|     |.....|.|....:
  Fly   182 ASSPCRNGATCTALAGSSSFTCSCPPGFTGD--TCSYDIEECQSNP-----CKYGGTCVNTHGSY 239

  Fly   195 LCKCKDGYEGDGEVLC-TDVDECRNPENCGPNALCTNTPGNYTCSCPDGYVGNNPYREGC-QDVD 257
            .|.|..||.|..   | |....| :|..|....:|.:...:|.|.||.|:.|.|     | |:.|
  Fly   240 QCMCPTGYTGKD---CDTKYKPC-SPSPCQNGGICRSNGLSYECKCPKGFEGKN-----CEQNYD 295

  Fly   258 ECSYPNVCGPGAICTNLEGSYRCDCPPGYDGDGRSESGCVDQ-DECARTP---CGRNADCLNTDG 318
            :| ..::|..|..|.:....|.|.|||.:.|     ..|.|. ||||:..   |...|.|.||.|
  Fly   296 DC-LGHLCQNGGTCIDGISDYTCRCPPNFTG-----RFCQDDVDECAQRDHPVCQNGATCTNTHG 354

  Fly   319 SFRCLCPDGYSG-DPMNGCEDVDECATNNPCGLGAECVNLGGSFQCRCPSG--FVLEH------- 373
            |:.|:|.:|::| |..|..:|..:.|    |..||.|::..|||.|:|..|  .:|.|       
  Fly   355 SYSCICVNGWAGLDCSNNTDDCKQAA----CFYGATCIDGVGSFYCQCTKGKTGLLCHLDDACTS 415

  Fly   374 DP-HADQL--PQPLNTQQLGYGPGATDIAPYQRTSGAGLACL-DIDECNQPDGVAKCGTNAKCIN 434
            :| |||.:  ..|:|      |..|...|    |...|:.|. |||||:|.   :.|..|..|:|
  Fly   416 NPCHADAICDTSPIN------GSYACSCA----TGYKGVDCSEDIDECDQG---SPCEHNGICVN 467

  Fly   435 FPGSYRCLCPSGFQGQGYLHCE-NINECQDNPCGENAICTDTVGSFVCTCKPDYTGDPFRGC-VD 497
            .||||||.|..||.|.   .|| |||||:.:||.....|.|..|:|.|.|.|.:||..   | :|
  Fly   468 TPGSYRCNCSQGFTGP---RCETNINECESHPCQNEGSCLDDPGTFRCVCMPGFTGTQ---CEID 526

  Fly   498 IDECTALDKPCGQHAVCENTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTNNAECIE 562
            ||||.:  .||.....|.:.:.|:.|.|..|:.|     ..|:   :||....:..|.|...|.:
  Fly   527 IDECQS--NPCLNDGTCHDKINGFKCSCALGFTG-----ARCQ---INIDDCQSQPCRNRGICHD 581

  Fly   563 N----QCFCLDGFEPIGSSC-VDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYVGSPPRMACK 622
            :    .|.|..|:  .|:|| ::|::|.::.  | ...:|::...|:.|.|:.||.|    ..|:
  Fly   582 SIAGYSCECPPGY--TGTSCEININDCDSNP--C-HRGKCIDDVNSFKCLCDPGYTG----YICQ 637

  Fly   623 Q---PCEDVRCGAHAYCKPDQNEAYCVCEDGWTYNPSDVAAGC-VDIDECDVMHGPFGSCGQNAT 683
            :   .||...|....:|:......||.|:.|.:      ...| |:::||   |.  ..|...||
  Fly   638 KQINECESNPCQFDGHCQDRVGSYYCQCQAGTS------GKNCEVNVNEC---HS--NPCNNGAT 691

  Fly   684 CTNSAGGFTCACPPGFSGDPHSKCVDVDECRTGASKCGAGAECVNVPGGGYTCRCP-----GNTI 743
            |.:....:.|.|.|||:|....|  :||||.  :|.|.....|:: ...||.|.||     .:.:
  Fly   692 CIDGINSYKCQCVPGFTGQHCEK--NVDECI--SSPCANNGVCID-QVNGYKCECPRGFYDAHCL 751

  Fly   744 ADPDPSVRCVPIVSCSANEDCPGNSICDATKRCLCPEPNIGNDCRHPCEALNCGAHAQCMLANGQ 808
            :|.|         .|::|                            ||  :|.|   :|.....:
  Fly   752 SDVD---------ECASN----------------------------PC--VNEG---RCEDGINE 774

  Fly   809 AQCLCAPGYTGNSALAGGCN-DIDECRANPCAEKAICSNTAGGYLCQCPGGSSGDPYR---EGCI 869
            ..|.|.|||||..     |. |||||.:|||.....|.:....:.|||..|.:|....   :.|:
  Fly   775 FICHCPPGYTGKR-----CELDIDECSSNPCQHGGTCYDKLNAFSCQCMPGYTGQKCETNIDDCV 834

  Fly   870 TSKTVGCSDANPCATGETCVQDSYTGNSVCICRQGYE-RNSENGQCQDVDECSVQRGKPACGLNA 933
            |         |||..|.||: |...|.. |:|:..:. |:.|:    .:|.|:..|         
  Fly   835 T---------NPCGNGGTCI-DKVNGYK-CVCKVPFTGRDCES----KMDPCASNR--------- 875

  Fly   934 LCKNLPGSYECRCPQGHNGNPFIMCEICNTPECQCQSPYKLVGNSC--VLSGCSSGQACPSGAEC 996
             |||     |.:|....|...|         .|.|:..|  .|..|  .:..||....|.:||.|
  Fly   876 -CKN-----EAKCTPSSNFLDF---------SCTCKLGY--TGRYCDEDIDECSLSSPCRNGASC 923

  Fly   997 ISIAGGVSY-CACPKGYQTQPDGSC-VDVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDA 1059
            :::.|  || |.|.|||:.:   .| ::.|:|   .:..|..|..|::..|.|||.|.:|:.|  
  Fly   924 LNVPG--SYRCLCTKGYEGR---DCAINTDDC---ASFPCQNGGTCLDGIGDYSCLCVDGFDG-- 978

  Fly  1060 YNGLCALAQRKCAADRECAANEKCIQPGECVCPPPYFLDPQDNNKCKSPCERFPCGINAKCTP-S 1123
                           :.|..                     |.|:|.|.    ||...|.|:. .
  Fly   979 ---------------KHCET---------------------DINECLSQ----PCQNGATCSQYV 1003

  Fly  1124 DPPQCMCEAGFKGDPLLGC-TDEDECSHLPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSGCIFES 1187
            :...|.|..||.|   :.| |::::|:...|..|..|::...||.|.|...|:|    :.|.:: 
  Fly  1004 NSYTCTCPLGFSG---INCQTNDEDCTESSCLNGGSCIDGINGYNCSCLAGYSG----ANCQYK- 1060

  Fly  1188 GTPKSKCLSNDDCASNLACLEGSCVSPCSSLLCGSNAYCETEQHAGWCRCRVGYVKNGDGDCVSQ 1252
               .:||.||       .||.|              |.|..:.:...|.|..|:......:.|..
  Fly  1061 ---LNKCDSN-------PCLNG--------------ATCHEQNNEYTCHCPSGFTGKQCSEYVDW 1101

  Fly  1253 CQDVICGDGALCIPTSEGPTCKCPQGQLGNPFPGGSCSTDQCSAARPCGERQICINGRCKERCEG 1317
            |....|.:||.|.......:|||..|..|......:.|....:..:....||:|.||.||:.   
  Fly  1102 CGQSPCENGATCSQMKHQFSCKCSAGWTGKLCDVQTISCQDAADRKGLSLRQLCNNGTCKDY--- 1163

  Fly  1318 VVCGIGATCDRNNGKCICEPNFVGNPDLICMPPIEQAKCSPGCGENAHCEYGLGQSRCACNPGTF 1382
                      .|:..|.|...:.|:   .|...|::.:..| |.....|...:|...|.|..|..
  Fly  1164 ----------GNSHVCYCSQGYAGS---YCQKEIDECQSQP-CQNGGTCRDLIGAYECQCRQGFQ 1214

  Fly  1383 GNPYEGCGAQSKNV--CQPNSCGPNAECRAVGNHISCLCPQGFSGNPYIGCQ-DVDECANKPCGL 1444
            |   :.|   ..|:  |.||.|.....|.....:.||.||.|..|   |.|: :.|:|....|..
  Fly  1215 G---QNC---ELNIDDCAPNPCQNGGTCHDRVMNFSCSCPPGTMG---IICEINKDDCKPGACHN 1270

  Fly  1445 NAACLNRAGGFECLCLSGHAGNPYSSCQPIESKFCQDANKCQCNERVECPEGYSCQKGQCKNL-- 1507
            |.:|::|.|||||:|..|..|   :.|:       .|.|:|..|              .|.|.  
  Fly  1271 NGSCIDRVGGFECVCQPGFVG---ARCE-------GDINECLSN--------------PCSNAGT 1311

  Fly  1508 --CSQASCGPRAICDAGNCICPMGYIGDPHDQVHGCSIRGQCGNDADCLHSEICFQLGKGLRKCV 1570
              |.|       :.:..:|.|..|::|                  ..|.|.             |
  Fly  1312 LDCVQ-------LVNNYHCNCRPGHMG------------------RHCEHK-------------V 1338

  Fly  1571 DACSKIQCGPNALCVSEDHRSSCICSDGFFGNPSNLQVGCQPERTVPEEEDKCKSDQDCSRGYGC 1635
            |.|::..|.....|........|||::||:|....|                  |.|||..    
  Fly  1339 DFCAQSPCQNGGNCNIRQSGHHCICNNGFYGKNCEL------------------SGQDCDS---- 1381

  Fly  1636 QASVNGIKECINLC--SNVVCGPNELCKINPAGHAI-CNCAESYVWNPVVSSCEKPSLPDCTSDA 1697
                       |.|  .|        |.:...|... |.|..    ..:...||..:|.:|:.:.
  Fly  1382 -----------NPCRVGN--------CVVADEGFGYRCECPR----GTLGEHCEIDTLDECSPNP 1423

  Fly  1698 NCPDASACRPDVLGVLKCVAICDAFTCPANSVCVARQHQGRCDCL-------NGFVGNPNDRNGC 1755
             |...:||. |:||..:|             :|.::....|||..       ||..|:.|||.. 
  Fly  1424 -CAQGAACE-DLLGDYEC-------------LCPSKWKGKRCDIYDANYPGWNGGSGSGNDRYA- 1472

  Fly  1756 QPAQKHHCRNHAECQESEA-CIKDESTQTLG---CRPACDTVKC-----------GPRAVCVTNN 1805
                       |:.::..| |.|...|:..|   |...|:|..|           .|.|.|..| 
  Fly  1473 -----------ADLEQQRAMCDKRGCTEKQGNGICDSDCNTYACNFDGNDCSLGINPWANCTAN- 1525

  Fly  1806 HQAQCQCPPGPFAGDPYDPF-NG-----CQSVPCVYN-HDCPPSQMCNRMTHTC---FDVCDEES 1860
                 :|         ::.| ||     |.:..|.|: ||      |.|...:|   ||...::.
  Fly  1526 -----EC---------WNKFKNGKCNEECNNAACHYDGHD------CERKLKSCDSLFDAYCQKH 1570

  Fly  1861 CGDNAICLAEDHRAVCQCPPGFKGDPLPEVACTKQGGCAAGTCHPSAI-CEVTPEGPV 1917
            .||                 ||         |  ..||....|....: ||...:.||
  Fly  1571 YGD-----------------GF---------C--DYGCNNAECSWDGLDCENKTQSPV 1600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 14/30 (47%)
EGF_CA 212..247 CDD:238011 10/34 (29%)
EGF_CA 255..>286 CDD:214542 10/30 (33%)
EGF_CA 298..331 CDD:238011 16/37 (43%)
EGF_CA 338..373 CDD:238011 13/36 (36%)
EGF_CA 413..456 CDD:238011 20/42 (48%)
EGF_CA 457..490 CDD:238011 15/32 (47%)
EGF_CA 497..>529 CDD:214542 11/31 (35%)
EGF_CA 580..>612 CDD:214542 7/31 (23%)
EGF_3 676..702 CDD:289699 9/25 (36%)
EGF_CA 1022..1056 CDD:214542 11/33 (33%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
NNP_001245510.1 EGF_CA 179..214 CDD:238011 16/36 (44%)
EGF_CA 217..252 CDD:238011 14/42 (33%)
EGF_CA 260..291 CDD:238011 10/35 (29%)
EGF_CA 295..329 CDD:238011 11/39 (28%)
EGF_CA 331..369 CDD:238011 15/37 (41%)
EGF_CA 449..486 CDD:238011 20/42 (48%)
EGF_CA 488..524 CDD:238011 16/38 (42%)
EGF_CA 526..562 CDD:238011 13/42 (31%)
EGF_CA 564..600 CDD:238011 10/37 (27%)
EGF_CA 602..637 CDD:238011 10/41 (24%)
EGF_CA 640..675 CDD:238011 8/40 (20%)
EGF_CA 677..713 CDD:238011 13/40 (33%)
EGF_CA 715..750 CDD:238011 12/37 (32%)
EGF_CA 753..789 CDD:238011 16/82 (20%)
EGF_CA 791..827 CDD:238011 14/35 (40%)
EGF_CA 829..865 CDD:238011 13/46 (28%)
EGF_CA 907..943 CDD:238011 14/40 (35%)
EGF_CA 946..982 CDD:238011 12/55 (22%)
EGF_CA 984..1020 CDD:238011 13/42 (31%)
EGF_CA 1027..1058 CDD:238011 9/34 (26%)
EGF_CA 1062..1095 CDD:238011 12/53 (23%)
EGF_CA 1184..1219 CDD:238011 10/41 (24%)
EGF_CA 1221..1257 CDD:238011 13/38 (34%)
EGF_CA 1259..1295 CDD:238011 14/38 (37%)
EGF_CA 1297..1335 CDD:238011 12/76 (16%)
EGF_CA 1417..1450 CDD:238011 9/47 (19%)
NL 1476..1512 CDD:197463 9/35 (26%)
Notch 1519..1553 CDD:278494 12/54 (22%)
Notch 1565..1593 CDD:278494 8/55 (15%)
NOD 1599..1648 CDD:284282 2/2 (100%)
NODP 1680..1731 CDD:284987
ANK 1896..2038 CDD:238125
ANK repeat 1902..1948 CDD:293786
ANK repeat 1951..1981 CDD:293786
Ank_5 1970..2025 CDD:290568
ANK 1978..2104 CDD:238125
ANK repeat 1984..2015 CDD:293786
ANK repeat 2017..2048 CDD:293786
Ank_2 2022..2114 CDD:289560
ANK repeat 2050..2081 CDD:293786
ANK repeat 2083..2114 CDD:293786
DUF3454 2627..2682 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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