DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and CG13366

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001036254.1	Gene:	CG13366 / 31004	FlyBaseID:	FBgn0025633	Length:	1094	Species:	Drosophila melanogaster

Alignment Length:	1089	Identity:	194/1089 - (17%)
Similarity:	318/1089 - (29%)	Gaps:	323/1089 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  6862 HSDQTTESTRDVPTTRPFEASTPSPASLETT-----VPSVTSETT------------TNVPIGST 6909
            |..|...|..:       ...:.|..||.|.     ..|:|:.||            ..|.:|..
  Fly    24 HKQQQNSSNNN-------RQKSQSSTSLNTAHEQQQQHSITAATTKFYAHQETASYERGVDVGDE 81

  Fly  6910 G-----GQVTEQTTSSPSEVRTTIGLEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSDQTT 6969
            |     .|..||.......::..   :.:|||.:.    |..:..:.|..||   :.:|||:
  Fly    82 GALLLTNQQQEQRRQQQQLLQQP---QSNTLPQKK----SKLKGQKQPKLLP---VQQPHSN--- 133

  Fly  6970 ESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGST--------GGQVT-------EQT 7019
                   ...|.:...|...||.....:....:::|..|.:.        ||...       :|.
  Fly   134 -------APEPHDPQQPLMTSLAAVPQASATGSSSNSNINNNNALAALQDGGAAAAAAADFYQQL 191

  Fly  7020 TSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFE 7084
            .::.:...|......|...:.|...:.|:.:........:..:.:....|....:.:....|..|
  Fly   192 AAAATATATATSANGSNTSADSPVSSFPAAAAAVAVAAVAASSYQQQQQQQQLLNNEQQQQQLLE 256

  Fly  7085 ASTP-----------RPVTLQ-----TAVLPVTSETTTNVPIGSTGGQVTEQTTSSPSEVRT-TI 7132
            |:..           |...:|     |.:||..||...     ..|..|..|:....|::.. .:
  Fly   257 ANNKMQELHKQMERFRSEQMQLETRITELLPYQSEVAK-----LKGDLVKMQSLQEKSQMEIGNL 316

  Fly  7133 RVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFESSTPRPVTLET 7197
            :.|..:|.:|.                 .|....|.||  .|..:.:..:|...||.|..:.|
  Fly   317 KYENESLRNRL-----------------RDVVNSPLSD--AEKHQIIQDSQRLHSSAPASIAL-- 360

  Fly  7198 AVPPVTSETTTNVPIGSTGGQVTEQTTP------SPSEVRTT------IRIEESTFPSRSTDRTT 7250
               |.|.:.....|.          .||      |.||:...      |::||:.:.:....:.|
  Fly   361 ---PSTHDAHDGTPC----------LTPDWDKQSSSSEISVACLQDKIIQMEETHYSTNEELQAT 412

  Fly  7251 PSESPETPTTLPSDFTTRPHSDQTTESTR-----DV------PTTRPFESSTPRPVTLEIAVPPV 7304
            ..|..:..|.|         :|..||:.|     ||      ..|.....|..:..||:..:...
  Fly   413 LQELADLQTQL---------TDTQTENERLAEEKDVLFQSLCRQTEKLNESRTQISTLQELLLRD 468

  Fly  7305 TSETTTNVAIGSTGGQVTEQTTSSPSEVRTTIRVEESTL--------PSRSTDRTTPSESPETPT 7361
            |.:....|:......::.:...:|..| |..:.:::..|        .:|...:.......|...
  Fly   469 TKQPAPEVSASEREQKLLDLIKTSQEE-REAVLLKQEELGAELAEMKQAREAGQLELQRQRERIA 532

  Fly  7362 TLPSDFTT-----RPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTSVPMGSTGG 7421
            .|.|....     |....|.:::..::           |..::|.:..|..||...|........
  Fly   533 LLDSQLDAANAERRQGEAQFSQAMEEI-----------SQRAIEISRLSTLLENARSKIEELEAD 586

  Fly  7422 QVTGQTTAPPSEVRTTIRVEESTLPSRST---DRTPPSESPETPTTLPSDFTTRPHSDQ---TTE 7480
            ...|..| ..|||....|.|:..|..|..   |:...|::           ..|...||   .||
  Fly   587 LSRGDKT-DLSEVLDVARKEKDALEERVAELQDQCSRSQA-----------ELRRLRDQLSGLTE 639

  Fly  7481 SSRDVPTTQ-----------------------PFESSTPRPVTLEI----------AVPPVTSET 7512
            ..:.|....                       .:::...|...|::          .:..:.:||
  Fly   640 ECKVVKNNAKCAVSHLEYRLEQLQRDKDKIAGEWQALEERVAELQVQCKCHQEDKAQLQSLLAET 704

  Fly  7513 TTNVPIGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTTPSESPE-------TPTTLPSD 7570
            ..::                 .:|:..:|..|..|...:..|...:|..:       ....:.:|
  Fly   705 QRHL-----------------GDVQLKLGEAECRLDQETQLRRKEAEEWQQFQADLLMTVRVAND 752

  Fly  7571 FTTRPHS-------DQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGSTGGQVT 7628
            |.|...|       |..|:..:    .|..|..               ||..|...:
  Fly   753 FKTEALSAREQLVLDNKTQKEK----IRLLEQQ---------------LEKLTKQQM-------- 790

  Fly  7629 GQTTATPSEVRTTIGVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTR 7693
             |.:.||..|.:|:..|......||....:..:|..:..||...........:..||.....:|.
  Fly   791 -QQSETPQSVLSTVQREMEMATRRSKLSFSRQDSRLSVKTLIESIENNKAQGKADESESHYSSTS 854

  Fly  7694 PFEASTPRPVTLETAVP-----------SVTSETTTNVPIGSTVTSETTTNVPIGSTGGQVAGQT 7747
            ...:.||...|.....|           .|...|..:|.:|:.|.:...||...|| ||.:|..|
  Fly   855 SLNSGTPDLGTTPIIFPPSSDWHESIRLPVLQSTNLHVNVGNEVGAGQGTNTSSGS-GGDLASTT 918

  Fly  7748 TAPPSEVRTTIRVEESTLPSRS----ADRTTPSE-----SPETPTTLPS 7787
            .|              |||.|.    |..:|.|:     .|.||.| ||
  Fly   919 KA--------------TLPLRDQQQLAITSTQSQVQNVSQPSTPAT-PS 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395	31/158 (20%)
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572	20/100 (20%)
		DUF4758	6866..7045	CDD:292572	37/215 (17%)
		DUF4758	6968..7179	CDD:292572	36/242 (15%)
		DUF4696	7024..7569	CDD:292395	102/643 (16%)
		DUF4758	7172..7383	CDD:292572	43/246 (17%)
		DUF4696	7330..7964	CDD:292395	98/544 (18%)
		DUF4758	7400..7587	CDD:292572	38/239 (16%)
		DUF4758	7538..7707	CDD:292572	33/182 (18%)
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
CG13366	NP_001036254.1	Ead_Ea22	554..684	CDD:290646	24/152 (16%)
CG13366	NP_001036254.1	CH	992..1092	CDD:237981
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910