DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and Lama2

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:XP_038954896.1 Gene:Lama2 / 309368 RGDID:1308889 Length:3121 Species:Rattus norvegicus


Alignment Length:1742 Identity:363/1742 - (20%)
Similarity:498/1742 - (28%) Gaps:719/1742 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly  9586 HIDPCYPNP------------CAENAVCTPYNNAARCTCIEPYNGDPYSTGCRPECIYSSECPSS 9638
            |.||...:|            .:...:|..|.:|..|..      ||.:...|.||.:::     
  Rat   259 HKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPL------DPATNKSRCECEHNT----- 312

  Fly  9639 LACIKQHCRDPCTAACGANAECTVVNHLPSCS-CTRGFEGNPFDGCKRVVVVRPETVCEPNPCGP 9702
                           ||           .||. |..||...|:    |......:|.||      
  Rat   313 ---------------CG-----------ESCDRCCPGFHQKPW----RAGTFLTKTECE------ 341

  Fly  9703 NSICRSVEGHPTCSCQVGYFGAPPQCRPECVVSSECAQHLSCINQKCMDPCVGTCGFNAKCQVNN 9767
                       .|:|.    |...:|..:..|:|   ::||                     :|.
  Rat   342 -----------ACNCH----GKAEECYYDETVAS---RNLS---------------------LNI 367

  Fly  9768 HNP-----IC-SCPANYEGNPFEQCM-----PKPAEPT--RNVDPCLPSPCGS-NSIC------- 9811
            |..     :| :|..|..|...|.|:     ||...|:  |...||...|.|| :.:|       
  Rat   368 HGKYIGGGVCINCTHNTAGINCETCIDGFFRPKGVSPSYPRPCQPCHCDPAGSLSEVCIKDEKHT 432

  Fly  9812 RNVNNRAECSCAPGMFGAPPNCRPECVIN----QDC-PSNRACIRQRCEDPCIGICGFNAVCSTQ 9871
            |.......|.|.||..|.  || ..||..    .|| |.|.:.:....:|||||           
  Rat   433 RRGLKPGSCYCKPGFGGM--NC-DRCVRGYRGYPDCQPCNCSGLGSTNQDPCIG----------- 483

  Fly  9872 NHQPKCSCIESFEGDPYTACKMREIVVLDPPTDPCYPSPCGANAIC-RVRNGAGSCSCIQNYFG- 9934
                .|||.|:.||:..:.||.....:.:.....|  ..|..:.:. |.::...:...||:..| 
  Rat   484 ----PCSCKENVEGEDCSHCKFGFFNLQEENQKGC--EECFCSGVSDRCQSSYWTYGNIQDMHGW 542

  Fly  9935 -----DPYINCRPECVQNSDCPNNRACINMKCRDPCANACGFNAICRVAHHQ-PVCSCEPHLT-- 9991
                 ...|...|: :.|.|.|...:..|.:.|....::..::|......:: |....:...|  
  Rat   543 YLTDLSGRIQVAPQ-LDNPDAPQQISVSNSEARRSLPDSYYWSAPAPYLRNKLPAVGGQLSFTIS 606

  Fly  9992 ---------------------GNPLRACVE------RPSNMY-----------------LPLPKD 10012
                                 ||.||....      .||..:                 ||:.:.
  Rat   607 YDLEEEEDDTEKILQLMIILEGNNLRISTAYKEVHLEPSEEHVEELSLKEESFTIHGTNLPVSRK 671

  Fly 10013 P------------------------CRPSPCGLFSTCHVVGER------PVCACLPDYMGA---- 10043
            .                        .|.|...|.|......:|      .||.|.|.|.|:    
  Rat   672 DFMILLTNLERVLIQTTYNLGMDVIFRLSSVNLESAVPYPTDRSIASAVEVCQCPPGYSGSSCEA 736

  Fly 10044 --PPN-----------CKP-ECMTSAECPSD--RACINQRCKDPCPGTCGYNARCRCTNHSPICS 10092
              |.:           |:| :|...||..:|  ..|::  |||...|              |.|:
  Rat   737 CWPRHRRVNGTIFGGLCEPCQCFGHAEACNDVTGECLS--CKDHTGG--------------PYCN 785

  Fly 10093 -CYDGYTGDP----FHQCVPERKPPPIADPI-VPPNPCVPSPCGPN-------SQCQVSSSGAVC 10144
             |..|:.|||    ...|      .|.|.|: :|.|...|: |..:       .:|.|..:|..|
  Rat   786 ECLPGFYGDPTRGTSEDC------QPCACPLNIPSNNFSPT-CHLDRSLGLICDECPVGYTGPRC 843

  Fly 10145 S-CVTNYIGRP--PG--CRP-ECSINSECPARMACINARCADPCIGSCGNNALCHVSLHAPVC-M 10202
            . |...|.|:|  ||  |:| .|:.|.:.....:|      |...|||   .:|........| :
  Rat   844 ERCAEGYFGQPSIPGGSCQPCLCNDNLDFSIPGSC------DSLSGSC---LICKPGTTGRFCEL 899

  Fly 10203 CEPGYSGDPF--SGCYKIIETPIEVIQPCRPSPCGLNALCEE--RNQAAACKCLPEYFGDPYVEC 10263
            |..||.||..  ..|           ||||   |.:|....|  ..:...|:|.|...|....||
  Rat   900 CADGYFGDAVDAKNC-----------QPCR---CNVNGSFSEICHRKTGQCECRPNVQGQRCDEC 950

  Fly 10264 RPE------------CVINS------DCPRSRACVNQKCVDPCPGMCGHNALCAVFNHAPNCE-C 10309
            :||            |..||      ||..|..|..|      ||:.|           ..|: |
  Rat   951 KPETFGLQLGRGCIPCNCNSFGSKSFDCEASGQCWCQ------PGVAG-----------KKCDRC 998

  Fly 10310 LPGYTGNPIVGCHIVPESPRYPDPIVPENPCQPSPCGLYSNCRPVNGHAVCSCVPSYIGSPPNCR 10374
            ..||......||                ..|..|..|  :||.|..|..:|         |||  
  Rat   999 AHGYFNFQEGGC----------------TACDCSHLG--NNCNPKTGQCIC---------PPN-- 1034

  Fly 10375 PECMSSSECAQDKSCLNERCKDPCPGTCGNNAL--CRVVNHNPI-------------CSCSPGFS 10424
                          .:.|:|.:..|.|.|::.:  |:|.|.:.:             |||.|.||
  Rat  1035 --------------TIGEKCSECLPNTWGHSIVTGCKVCNCSTVGSLSSQCNINTGQCSCHPKFS 1085

  Fly 10425 GDPFVRCFPQEKRPPITHDRIDPCVPSPCGPNSECRVSAANEQ--AVCSCLQHYVGRAPNCRPEC 10487
            |   ::|                         |||.....|..  ::|.|.              
  Rat  1086 G---MKC-------------------------SECNRGHWNYPLCSLCDCF-------------- 1108

  Fly 10488 TSDSECPGNLACINLRCRDPCVGTCGIQTTCLVNNHRPICRCIDGYAGDPFSECSPKINVPVQVA 10552
                 .||..|                 |||  ::....|.|     .|...:|:.|:||.....
  Rat  1109 -----LPGTDA-----------------TTC--DSETRKCSC-----SDQTGQCTCKVNVEGVHC 1144

  Fly 10553 QPCNPSPCGANAVCKERNGVGSCSCLPEYNGDPYTECRPECVLNSDCSKNRACLNN--KCRDPCP 10615
            ..|.|...|..|  |...|..||.|..               :.|.||:.:..:..  ..||.  
  Rat  1145 DRCRPGKFGLEA--KNPLGCSSCYCFG---------------VTSQCSEAKGLVRTWVTLRDE-- 1190

  Fly 10616 GVCGVSAECHVINHAPSCSCPSGFT-GNPSQFCR--EIP----------RLPAPVEPCRPSPCGP 10667
                 .....:::.|...:...|.. .||....:  |:.          :||...|..:....|.
  Rat  1191 -----QTILPLVDEALQHTTTKGIAFQNPEIVAKMDEVRQDLHLEPFYWKLPEQFEGKKLMAYGG 1250

  Fly 10668 ------YSQCREVNGHAV--------------CSCVTNYIGTP---PACRPECSVSSE------- 10702
                  |.:.|:..|.|.              ...:|.::..|   ...|.|..::.:       
  Rat  1251 KLKYTIYFEARDETGFATYKPQVIIRGGTPTHARIITRHMAAPLIGQLTRHEIEMTEKEWKYYGD 1315

  Fly 10703 --------------------------------CAQDRAC-VNQRCADPCPGTCGN-EAICKVTNH 10733
                                            ..|.|.. ::...|:|     |. .|...:.|.
  Rat  1316 DPRISRTVTREDFLDILYDIHYILIKATYGNVVRQSRISEISMEGAEP-----GQVSAASPLANL 1375

  Fly 10734 NPICSCPAGYSGDPFVRCAPW----QEEP--EQPKSNENPCVPSPC-GRNSQCRVVGETGVCSCL 10791
            ...|.||.||||.....|||.    ..||  ..|......|||..| |.:|||.  .||.||.  
  Rat  1376 IERCDCPPGYSGLSCETCAPGFYRVHSEPGGRTPGPTLGTCVPCQCHGHSSQCD--PETSVCQ-- 1436

  Fly 10792 PNFVGRAPNCRPECTINTECPANLACINERCQ--------------DPCPGSCGFNAFCSVV--- 10839
                    ||:.. |....|        |||.              .||.        |.::   
  Rat  1437 --------NCQHH-TAGDFC--------ERCALGYYGIVRGLPNDCQPCA--------CPLISPS 1476

  Fly 10840 -NHSPIC-----------TCDSGYTGDPFAGCNP---QPPAIPDERLTPCQ-------PSPCGPN 10882
             |.||.|           .|..||.|.....|.|   ..|:.|......|:       |.||.| 
  Rat  1477 NNFSPSCVLEGLEDYRCTACPRGYEGQYCERCAPGYAGSPSSPGGSCQECECDPYGSLPVPCDP- 1540

  Fly 10883 AECRERNGAGSCTCLPEYFGDPYSGCR-------PECVVNSDCSRDKSCVNQKCVDPCPG-VCGL 10939
                   ..|.|||.|...|....||.       .|||.              |.|.|.| :.|.
  Rat  1541 -------VTGLCTCRPGATGRKCDGCEHGHAREGAECVF--------------CGDECTGLLLGD 1584

  Fly 10940 NAQCRVSNHLPSCSCLAGYTG----------NPSSACREIPQLPPP---PER 10978
            .|      ||...:.....||          ...:|.:|:..|..|   |||
  Rat  1585 LA------HLEQMAMNINLTGPLPAPYKILYGLENATQELKHLLSPQRAPER 1630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
Lama2XP_038954896.1 Laminin_N 39..284 CDD:395009 4/24 (17%)
EGF_Lam 286..333 CDD:238012 18/87 (21%)
Laminin_EGF 413..470 CDD:395007 18/59 (31%)
Laminin_EGF 468..514 CDD:395007 14/60 (23%)
Laminin_B 582..721 CDD:395006 16/138 (12%)
EGF_Lam 755..804 CDD:238012 18/70 (26%)
EGF_Lam 805..862 CDD:238012 17/57 (30%)
EGF_Lam 863..915 CDD:238012 16/71 (23%)
EGF_Lam 916..963 CDD:238012 14/49 (29%)
EGF_Lam 966..1010 CDD:214543 15/60 (25%)
EGF_Lam 1012..1057 CDD:238012 16/71 (23%)
Laminin_EGF 1059..1107 CDD:395007 14/75 (19%)
Laminin_EGF 1105..1162 CDD:395007 20/101 (20%)
LamB 1228..1363 CDD:214597 15/134 (11%)
EGF_Lam <1378..1406 CDD:238012 12/27 (44%)
Laminin_EGF 1419..1465 CDD:395007 16/66 (24%)
Laminin_EGF 1468..1523 CDD:395007 14/62 (23%)
EGF_Lam 1526..>1563 CDD:238012 13/44 (30%)
Laminin_I 1593..1851 CDD:310534 9/38 (24%)
SMC_prok_B <1675..>2033 CDD:274008
Laminin_II 2036..2171 CDD:368703
Laminin_G_1 2173..2313 CDD:395008
Laminin_G_1 2367..2506 CDD:395008
LamG 2527..2689 CDD:238058
Laminin_G_1 2792..2920 CDD:395008
LamG 2940..3092 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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