DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and Cd22

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001100973.1 Gene:Cd22 / 308501 RGDID:1311610 Length:852 Species:Rattus norvegicus


Alignment Length:776 Identity:154/776 - (19%)
Similarity:242/776 - (31%) Gaps:266/776 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  7660 SESPETP-TTLPSDFTTRPHSDQTTESTR--------------DVPTTRPFEASTPRPVT--LET 7707
            ||.|..| ..|||:.         .||.|              |:......:.|...|||  :.:
  Rat   143 SERPFQPYIQLPSEI---------RESQRVSLTCGLNFTCFGYDISLRWSLDGSEVSPVTSSITS 198

  Fly  7708 AVPSVTSET---------------TTNVPIGSTVTSETTTNVPIGSTGGQVAGQTTAPPSEVR-- 7755
            :|.:|.:|:               ...|...|.|.||.|..:.:..|...   |.|..|:||:  
  Rat   199 SVENVYTESKLTFQPKWTDHGKSMMCQVWHFSQVLSERTVRLDVKYTPKL---QITVNPTEVKEG 260

  Fly  7756 ----TTIRVEESTLPSRSADRTT--------PSESPETPTTLPS-------DFTTRPHSEQTTES 7801
                .|.:|..|. ||.|..:.:        ..:..:...||.|       .:..|..:......
  Rat   261 NSVTMTCQVNSSN-PSLSTKKVSWFKDGSFLKEQQEQEELTLHSVTKDMRGKYQCRASNNIGQGQ 324

  Fly  7802 TRDVPTT--RPFEAST----PSPA----SLETTVPSVTSETTTN---------VPIGSTGGQLTE 7847
            :::|..|  .|.|.|.    ||||    |:|....|:.|...||         || |::..:|..
  Rat   325 SKEVALTVLYPPEPSKVHIYPSPAEEGQSVELICDSLASPRATNYTWYHNGEMVP-GASHEKLQI 388

  Fly  7848 QSTS------------------------------SPSEVRTTIRVEESTLPSRSTDRT-----FP 7877
            .:.|                              .|..|.|.|   :|..|.|..|..     :.
  Rat   389 SNVSLWHAGKYSCLAENRLGCGKIEQEAELDVHYVPKAVTTVI---QSVTPIREGDSVTLDCRYN 450

  Fly  7878 SESPE------KPTTLPSDFTTRPHLEQTTESTRDVLTTRP-------FETSTPSPVSLET---- 7925
            |.:||      .|....|:.|  |.:.:..::|.|   :.|       ::.|...||||..    
  Rat   451 SSNPEVTKYEWSPQGSGSEVT--PGVLRIQKATWD---SPPIKCAACNYKCSWSFPVSLNVHYAP 510

  Fly  7926 -TVPSVTSETSTNVPIGSTGGQVTEQT----TAPPSVR----TTETIVKS----THPAVSPDTT- 7976
             .|..:....::.:   ..|..|..|.    :.|..||    ....:|:.    ...::||:.: 
  Rat   511 RAVKILKVSPASEI---HAGQHVLLQCDFSGSFPTEVRFFWKKNGNLVQEGRYLNFSSISPEDSG 572

  Fly  7977 -----IPSEIPATRVPLESTTRLYTDQ----TIPPGSTDRTTSSERPDESTRLTSEESTETTRPV 8032
                 :.:.|..|.....|...||..:    :|.||.:..        |..:.|....::...||
  Rat   573 NYNCMVRNSIGETSSQAWSLQVLYAPRRLRVSISPGDSVM--------EGKKATLSCESDAHPPV 629

  Fly  8033 PTVSPRDA----LETTVTSLITETTKTTSGGTPRGQVTERTTKSVSELTTGRSSDVVTERTMPSN 8093
            ......||    |..:...|..|..:....|:.|.|       .::||.||:|.           
  Rat   630 FKYIWFDANDQDLHFSGQKLRLEPLRVQHTGSYRCQ-------GINELGTGKSP----------- 676

  Fly  8094 ISSTTTVFNNSEPVSDNLPTTISITVTDSPTTVPVPTCKTDYDCLDEQTCIG-GQCISPCEYFTN 8157
                              |:|  :||..||.|:            .::..:| |.|::.|     
  Rat   677 ------------------PST--LTVYYSPETI------------GKRVALGLGFCLAIC----- 704

  Fly  8158 LCTVQNLTICRTLNHTTKCYCDTDDDVNRPDCSMKAEIGCASSDECPSQQACINALCVDPCTFNN 8222
            :..:..:.|.:...|........|:...:.......:.......|.|..|.|.| |.:|. |.:.
  Rat   705 ILAIWGMKIQKKWKHNRSQQGPQDNSSGQSFFVRNKKARRTRLTEGPQSQGCYN-LAMDD-TVSY 767

  Fly  8223 PCSRNEDCRVFNHQPLCSAEHG----RTPGCEHCPPGANCDPTTGACIKANVTITTITTKN 8279
            ...|..:          |..||    |:|..:..||  |.|.|        ||.:.:..:|
  Rat   768 AVLRFPE----------SDTHGAGGARSPATQGPPP--NDDDT--------VTYSVLQKRN 808

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395 90/436 (21%)
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572 15/63 (24%)
DUF4758 7798..7979 CDD:292572 53/270 (20%)
DUF4758 7946..8126 CDD:292572 39/205 (19%)
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
Cd22NP_001100973.1 Ig 24..143 CDD:416386 154/776 (20%)
FR1 24..47 CDD:409353
Ig strand A 24..28 CDD:409353
Ig strand A' 31..35 CDD:409353
Ig strand B 37..48 CDD:409353
CDR1 48..56 CDD:409353
Ig strand C 56..63 CDD:409353
FR2 57..63 CDD:409353
CDR2 64..95 CDD:409353
Ig strand C1 65..68 CDD:409353
Ig strand C2 71..75 CDD:409353
Ig strand C' 79..82 CDD:409353
FR3 96..129 CDD:409353
Ig strand D 97..101 CDD:409353
Ig strand E 106..114 CDD:409353
Ig strand F 121..129 CDD:409353
CDR3 130..132 CDD:409353
FR4 133..143 CDD:409353 154/776 (20%)
Ig strand G 133..143 CDD:409353 154/776 (20%)
IgC1_CD22_d2 147..242 CDD:409532 21/103 (20%)
Ig strand B 163..167 CDD:409532 0/3 (0%)
Ig strand C 179..183 CDD:409532 0/3 (0%)
Ig strand E 207..211 CDD:409532 0/3 (0%)
Ig strand F 221..226 CDD:409532 0/4 (0%)
Ig strand G 235..238 CDD:409532 1/2 (50%)
Ig 246..334 CDD:416386 17/91 (19%)
Ig strand A 246..253 CDD:409353 2/9 (22%)
Ig strand B 260..270 CDD:409353 1/9 (11%)
Ig strand C 277..285 CDD:409353 1/7 (14%)
Ig strand C' 287..290 CDD:409353 0/2 (0%)
Ig strand E 296..303 CDD:409353 2/6 (33%)
Ig strand F 310..318 CDD:409353 1/7 (14%)
Ig strand G 321..334 CDD:409353 2/12 (17%)
IGc2 350..408 CDD:197706 11/58 (19%)
Ig strand B 354..358 CDD:409353 1/3 (33%)
Ig strand C 367..372 CDD:409353 2/4 (50%)
Ig strand F 398..403 CDD:409353 0/4 (0%)
Ig 424..>466 CDD:416386 12/44 (27%)
Ig strand A 424..431 CDD:409353 3/6 (50%)
Ig strand A' 435..439 CDD:409353 1/3 (33%)
Ig strand B 440..450 CDD:409353 1/9 (11%)
Ig strand C 457..463 CDD:409353 0/5 (0%)
IGc2 527..583 CDD:197706 9/55 (16%)
Ig strand B 530..534 CDD:409353 1/3 (33%)
Ig strand C 543..549 CDD:409353 2/5 (40%)
Ig strand F 573..578 CDD:409353 0/4 (0%)
IG 610..682 CDD:214652 19/117 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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