DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and notch1a

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_571516.1 Gene:notch1a / 30718 ZFINID:ZDB-GENE-990415-173 Length:2437 Species:Danio rerio


Alignment Length:2126 Identity:511/2126 - (24%)
Similarity:727/2126 - (34%) Gaps:698/2126 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 QVNESTEYLQLFNLSKLCD----GTQDCFLGADELSKELKCTNDCDKDGTKCTHGACLN------ 111
            |....:||.|   ...:|:    |...|...||.:..:.:..|.|:.  :.|.:|....      
Zfish    21 QGQRCSEYCQ---NGGICEYKPSGEASCRCPADFVGAQCQFPNPCNP--SPCRNGGVCRPQMQGN 80

  Fly   112 --GV-CHCNDGYGGCNCVDKDENECKQRPCDVFAHCT-NTLGSFTCTCFPGYRGNGFHCEDIDEC 172
              || |.|..|:....|:....:.|...||.....|: .||.:|||.|.||:.|.        .|
Zfish    81 EVGVKCDCVLGFSDRLCLTPVNHACMNSPCRNGGTCSLLTLDTFTCRCQPGWSGK--------TC 137

  Fly   173 Q--DPAIAARCVENAECCNLPAHFLCKCKDGYEGDGEVLCTDVDECR-NPENCGPNALCTNTPGN 234
            |  ||..:..|....:|....:|::|.|...:.  |:....||:||. :|..|.....|.|..|:
Zfish   138 QLADPCASNPCANGGQCSAFESHYICTCPPNFH--GQTCRQDVNECAVSPSPCRNGGTCINEVGS 200

  Fly   235 YTCSCPDGYVGNNPYREGCQDVDECSYPNVCGPGAICTNL-EGSYRCDCPPGYDGDGRSESGCVD 298
            |.|.||..|.|  |:   ||.:.:...|:.|..|..|... :.::.|.|.||:.|.....    :
Zfish   201 YLCRCPPEYTG--PH---CQRLYQPCLPSPCRSGGTCVQTSDTTHTCSCLPGFTGQTCEH----N 256

  Fly   299 QDECARTPCGRNADCLNTDGSFRCLCPDGYSGDPMNGCEDVDECATN-NPCGLGAECVNLGGSFQ 362
            .|:|.:..|.....|::...::.|.|...::|....  ||||||..: |.|..|..|.|..|.|.
Zfish   257 VDDCTQHACENGGPCIDGINTYNCHCDKHWTGQYCT--EDVDECELSPNACQNGGTCHNTIGGFH 319

  Fly   363 CRCPSGFVLEHDPHADQLPQPLNTQQLGYGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAKCG 427
            |.|.:|:.                     |...::               :||:|    ..|.|.
Zfish   320 CVCVNGWT---------------------GDDCSE---------------NIDDC----ASAACS 344

  Fly   428 TNAKCINFPGSYRCLCPSGFQGQGYLHCENINECQDNPCGENAIC-TDTV-GSFVCTCKPDYTGD 490
            ..|.|.:...|:.|.||.|..|   |.|...:.|..|||.:.:.| |:.| |..:|||.|.|||.
Zfish   345 HGATCHDRVASFFCECPHGRTG---LLCHLDDACISNPCQKGSNCDTNPVSGKAICTCPPGYTGS 406

  Fly   491 PFRGC-VDIDECTALDKPCGQHAVCENTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCSSNFDC 554
               .| .|||||:....||.....|.||...:.|||.|||:|   |:  || :||| .|.|| .|
Zfish   407 ---ACNQDIDECSLGANPCEHGGRCLNTKGSFQCKCLQGYEG---PR--CE-MDVN-ECKSN-PC 460

  Fly   555 TNNAECIEN----QCFCLDGFEPIGSSC-VDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYVG 614
            .|:|.|::.    .|.|:.|:|  |..| ::.|:|.:...:.|   :|::...|:.|||..|:.|
Zfish   461 QNDATCLDQIGGFHCICMPGYE--GVFCQINSDDCASQPCLNG---KCIDKINSFHCECPKGFSG 520

  Fly   615 SPPRMACKQPCEDVRCGAHAYCKPDQNEAYCVCEDGWTYNPSDVAAGCVDIDECDVMHGPFGSCG 679
            |                              :|:              ||:|||     ....|.
Zfish   521 S------------------------------LCQ--------------VDVDEC-----ASTPCK 536

  Fly   680 QNATCTNSAGGFTCACPPGFSGDPHSKCVDVDECRTGASKCGAGAECVNVPGGGYTCRC-PGNTI 743
            ..|.||:....:||.|.||||| .|.: :|::||.:.....|...:.|    ..:||.| ||.| 
Zfish   537 NGAKCTDGPNKYTCECTPGFSG-IHCE-LDINECASSPCHYGVCRDGV----ASFTCDCRPGYT- 594

  Fly   744 ADPDPSVRCVPIVSCSANEDCPGNSICDATKR---CLCPEPNIGNDC--------RHPCEALNCG 797
                 ...|...::...::.|.....|...:.   |.||:...|.:|        |.||:     
Zfish   595 -----GRLCETNINECLSQPCRNGGTCQDRENAYICTCPKGTTGVNCEINIDDCKRKPCD----- 649

  Fly   798 AHAQCMLANGQAQCLCAPGYTGNSALAGGCN-DIDECRANPCAEKAICSNTAGGYLCQCPGGSSG 861
             :.:|:......:|:|.|||:|:.     || :||:|..|||.....|.:....:.|.||.|   
Zfish   650 -YGKCIDKINGYECVCEPGYSGSM-----CNINIDDCALNPCHNGGTCIDGVNSFTCLCPDG--- 705

  Fly   862 DPYREGCITSKTVGCSDANPCATGETCVQ--DSYTGNSVCICRQGY-ERNSENGQCQ-DVDECSV 922
              :|:....|:...|| :|||..| :|:.  :||.    |:|..|: .||     |. :::||  
Zfish   706 --FRDATCLSQHNECS-SNPCIHG-SCLDQINSYR----CVCEAGWMGRN-----CDININEC-- 755

  Fly   923 QRGKPACGLNALCKNLPGSYECRCPQGHNGNPFIMCEICNTPECQCQSPYKLVGNSCVLSGCSSG 987
             ...| |.....||::...|.|.|..|.:|           |.||...      |.|..:.|.: 
Zfish   756 -LSNP-CVNGGTCKDMTSGYLCTCRAGFSG-----------PNCQMNI------NECASNPCLN- 800

  Fly   988 QACPSGAECISIAGGVSYCACPKGYQTQPDGSCVDVDECEERGAQLCAFGAQCVNKPGSYSCHCP 1052
                                         .|||:|                    ....:.|:|.
Zfish   801 -----------------------------QGSCID--------------------DVAGFKCNCM 816

  Fly  1053 EGYQGDAYNGLCALAQRKCAADRECAANEKCIQPGECVCPPPYFLDPQDNNKCKSPCERFPCGIN 1117
            ..|.|:....:.|                                          ||...||...
Zfish   817 LPYTGEVCENVLA------------------------------------------PCSPRPCKNG 839

  Fly  1118 AKCTPSDPPQ---CMCEAGFKGDPLLGC-TDEDECSHLPCAYGAYCVNKKGGYQCVCPKDYTGDP 1178
            ..|..|:..|   |.|.||::|..   | .|.:||...||..|..|.|.:||:||.|...:||  
Zfish   840 GVCRESEDFQSFSCNCPAGWQGQT---CEVDINECVRNPCTNGGVCENLRGGFQCRCNPGFTG-- 899

  Fly  1179 YKSGCIFESGTPKSKCLSN-DDCASNLACLEGSCVSPCSSLLCGSNAYCETEQHAGWCRCRVGYV 1242
                         :.|.:: |||..|          |||     :...|:...:...|.|..|:.
Zfish   900 -------------ALCENDIDDCEPN----------PCS-----NGGVCQDRVNGFVCVCLAGFR 936

  Fly  1243 KNGDGDCVSQCQDVICGDGALCIPTSEGPTCKCPQGQLGNPFPGGSC--STDQCSAARPCGERQI 1305
            .....:.:.:|....|.:|..|.......||.||.|     |.|.:|  :|..|:.:.       
Zfish   937 GERCAEDIDECVSAPCRNGGNCTDCVNSYTCSCPAG-----FSGINCEINTPDCTESS------- 989

  Fly  1306 CIN-GRCKERCEGVVCGIGATCDRNNGKCICEPNFVGNPDLICMPPIEQAKCSPGCGENAHCEYG 1369
            |.| |.|       |.||      ::..|:|.|.|.||   .|...:.:....| |.....|:.|
Zfish   990 CFNGGTC-------VDGI------SSFSCVCLPGFTGN---YCQHDVNECDSRP-CQNGGSCQDG 1037

  Fly  1370 LGQSRCACNPGTFGNPYEGCGAQS-KNVCQPNSCGPNAECRAVGNHISCLCPQGFSG----NPYI 1429
            .|..:|.|..|     |.|...|| ...|..:.|.....|...|...:|.|..|::|    .|.:
Zfish  1038 YGTYKCTCPHG-----YTGLNCQSLVRWCDSSPCKNGGSCWQQGASFTCQCASGWTGIYCDVPSV 1097

  Fly  1430 GCQDVDECANKPCGLNAACLNRAGG--------FECLCLSGHAGNPYSSCQPIESKFCQD-ANKC 1485
            .|    |.|.:..|::.|.|.|..|        ..|.|.:|:.|:           :||: .::|
Zfish  1098 SC----EVAARQQGVSVAVLCRHAGQCVDAGNTHLCRCQAGYTGS-----------YCQEQVDEC 1147

  Fly  1486 Q---CNERVECPE---GYSCQKGQCKNLCSQASCGPRAICDAGNCICPMGYIGDPHDQVHG--CS 1542
            |   |.....|.:   ||||:                         |..||        ||  ||
Zfish  1148 QPNPCQNGATCTDYLGGYSCE-------------------------CVPGY--------HGMNCS 1179

  Fly  1543 IRGQCGNDADCLHSEICFQLGKGLRKCVDACSKIQCGPNALCVSEDHRSSCICSDGFFGNPSNLQ 1607
                                     |.::.|....|.....|:...:...|.|..|..|....:.
Zfish  1180 -------------------------KEINECLSQPCQNGGTCIDLVNTYKCSCPRGTQGVHCEID 1219

  Fly  1608 V-GCQPERTVPEEEDKCKSDQDC---SRGYGCQASVNGIKECINLCSNVVCGPNELCKINPAGHA 1668
            : .|.|.......|.:|.:...|   ..||||                 ||         |||. 
Zfish  1220 IDDCSPSVDPLTGEPRCFNGGRCVDRVGGYGC-----------------VC---------PAGF- 1257

  Fly  1669 ICNCAESYVWNPVVSSCEKPSLPDCTSDANCPDASACRPDVLGVLKCVAICDAFTCPANSVCVAR 1733
                        |...|| ..:.:|.||       .|.|.  |...||.:.:.|           
Zfish  1258 ------------VGERCE-GDVNECLSD-------PCDPS--GSYNCVQLINDF----------- 1289

  Fly  1734 QHQGRCDCLNGFVGNPNDR--NGCQPAQKHHCRNHAECQESEACIKDESTQTLGCRPACDTVKCG 1796
                ||:|..|:.|...:.  |||:...   |:|...|                           
Zfish  1290 ----RCECRTGYTGKRCETVFNGCKDTP---CKNGGTC--------------------------- 1320

  Fly  1797 PRAVCVTNNHQAQCQCPPGPFAGDPYDPFNGCQSVPCVYNHDCPPSQMCNRMTHTCFDVCDEESC 1861
              ||.....|...|:|.|| ::|.           .|.|:     ||.|..:           .|
Zfish  1321 --AVASNTKHGYICKCQPG-YSGS-----------SCEYD-----SQSCGSL-----------RC 1355

  Fly  1862 GDNAICLAEDHRAVCQCPPGFKGDPLPEVACTKQGGCAAGTCHPSAICEVTPEGPV--CKCPPLF 1924
            .:.|.|::......|.|.|||.|.   |........|....|:....|:...:.|.  |.||..|
Zfish  1356 RNGATCVSGHLSPRCLCAPGFSGH---ECQTRMDSPCLVNPCYNGGTCQPISDAPFYRCSCPANF 1417

  Fly  1925 VG-------DAKSGGCRPD-------------GQCP--NGDADCPANTICAGGVCQNPCDN-ACG 1966
            .|       .:.|||...|             .||.  .|:|           :|...|:| |||
Zfish  1418 NGLLCHILDYSFSGGQGRDIAPPVEVEIRCEIAQCEGRGGNA-----------ICDTQCNNHACG 1471

  Fly  1967 -SNAECKVINRKPVCSCPLRFQPISDTAKDGCARTISKCLTDVDCGGALC-YNGQCRIACRNSQD 2029
             ...:|.:....|..:|....|         |.|..:....|..|..|.| |:|         .|
Zfish  1472 WDGGDCSLNFDDPWQNCSAALQ---------CWRYFNDGKCDEQCATAGCLYDG---------FD 1518

  Fly  2030 CSDGESCLKNVCVVACLDHSQCASGLACVEGHCTIGCRSNKECKQD 2075
            |...|.....:....|.||        ..:|||..|| :|.||:.|
Zfish  1519 CQRLEGQCNPLYDQYCRDH--------YADGHCDQGC-NNAECEWD 1555

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 12/29 (41%)
EGF_CA 212..247 CDD:238011 15/35 (43%)
EGF_CA 255..>286 CDD:214542 7/31 (23%)
EGF_CA 298..331 CDD:238011 6/32 (19%)
EGF_CA 338..373 CDD:238011 15/35 (43%)
EGF_CA 413..456 CDD:238011 14/42 (33%)
EGF_CA 457..490 CDD:238011 14/34 (41%)
EGF_CA 497..>529 CDD:214542 14/31 (45%)
EGF_CA 580..>612 CDD:214542 8/31 (26%)
EGF_3 676..702 CDD:289699 11/25 (44%)
EGF_CA 1022..1056 CDD:214542 3/33 (9%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
notch1aNP_571516.1 EGF_CA 141..174 CDD:238011 8/34 (24%)
EGF_CA 177..215 CDD:238011 16/42 (38%)
EGF_CA 294..331 CDD:238011 16/57 (28%)
EGF_CA 334..369 CDD:238011 14/41 (34%)
EGF_CA 411..449 CDD:238011 18/42 (43%)
EGF_CA 451..487 CDD:238011 15/39 (38%)
EGF_CA 491..524 CDD:238011 11/65 (17%)
EGF_CA 526..562 CDD:238011 17/41 (41%)
EGF_CA 564..599 CDD:238011 11/44 (25%)
EGF_CA 601..637 CDD:238011 6/35 (17%)
EGF_CA 676..711 CDD:238011 12/39 (31%)
EGF_CA 716..748 CDD:238011 14/42 (33%)
EGF_CA 751..787 CDD:238011 12/50 (24%)
EGF_CA 789..825 CDD:238011 11/91 (12%)
EGF_CA 867..903 CDD:238011 15/50 (30%)
EGF_CA 905..940 CDD:238011 11/49 (22%)
EGF_CA 943..979 CDD:238011 11/40 (28%)
EGF_CA 986..1017 CDD:238011 13/53 (25%)
EGF_CA 1019..1055 CDD:238011 10/41 (24%)
EGF_CA 1144..1178 CDD:238011 13/66 (20%)
EGF_CA 1182..1217 CDD:238011 7/34 (21%)
EGF_CA 1219..1263 CDD:238011 15/82 (18%)
EGF_CA 1265..1303 CDD:238011 14/61 (23%)
NL 1440..1477 CDD:197463 10/47 (21%)
LNR 1 1447..1487 12/50 (24%)
Notch 1485..1520 CDD:278494 11/52 (21%)
LNR 2 1488..1525 13/54 (24%)
Notch 1523..1559 CDD:278494 13/42 (31%)
LNR 3 1526..1566 12/39 (31%)
NOD 1565..1616 CDD:284282
NODP 1664..1721 CDD:284987
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1770..1790
Ank_2 <1860..1946 CDD:289560
ANK 1862..2003 CDD:238125
ANK repeat 1867..1913 CDD:293786
ANK 1 1867..1910
ANK repeat 1915..1946 CDD:293786
ANK 2 1915..1944
Ank_2 1920..2013 CDD:289560
ANK repeat 1948..1979 CDD:293786
ANK 3 1948..1978
ANK 1977..2101 CDD:238125
ANK 4 1982..2011
Ank_2 1987..2079 CDD:289560
ANK repeat 2015..2079 CDD:293786
ANK 5 2015..2044
ANK 6 2048..2077
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2127..2174
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2356..2437
DUF3454 2364..2424 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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