DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Matn2

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_216941.8	Gene:	Matn2 / 299996	RGDID:	1305353	Length:	954	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	149/557 - (26%)
Similarity:	203/557 - (36%)	Gaps:	165/557 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 CT-NDCDKDGTKCTHGACLNG----VCHCNDGYGGCNCVDKDENECK-QRPCDVFAH-----CTN 146
            || :.|......|.| .|:|.    .|.|..||    .:..|:..|: |..|....|     |.|
  Rat   236 CTVHMCSVLEHNCAH-FCINTPGSYTCKCKQGY----ILGPDQKTCRIQDLCATEDHGCEQLCVN 295

  Fly   147 TLGSFTCTCFPGY--RGNGFHCEDIDECQDPAIAARCVENAECCNLPAHFLCKCKDGYE-GDGEV 208
            .||||.|.|:.||  ..:|..|..:|.|...  ..||  ..||.|....:||:|.:|:. ...:.
  Rat   296 MLGSFVCHCYSGYTLAEDGKQCTAVDYCASE--NHRC--EHECVNAEGSYLCRCHEGFALNVDKK 356

  Fly   209 LCTDVDECRNPENCGPNALCTNTPGNYTCSCPDGYVGNNPYREGCQDVDECSYPNVCGPGAICTN 273
            .|:.:|.|.:.:: |....|.|...:..|.|..|:: .||.|:.|:.::.|:. |..|....|.|
  Rat   357 TCSKIDYCASSDH-GCQHECVNAQTSAFCRCLKGFM-LNPDRKTCRRINYCAL-NKPGCEHECVN 418

  Fly   274 LEGSYRCDCPPGY--DGDGRSESGCVDQDECARTPCGRNADCLNTDGSFRCLCPDGY-SGDPMNG 335
            .|..:.|.|..||  |.:|::   |...|.||:...|....||||:.||.|.|.:|: ..|.:..
  Rat   419 TEEGHYCRCRRGYTLDPNGKT---CSRVDHCAQQDHGCEQLCLNTEESFVCQCSEGFLINDDLKT 480

  Fly   336 CEDVDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQLGYGPGATDIAP 400
            |...|.|..:|. |....|||...||.|:||.|.||..|
  Rat   481 CSRADYCLLSNH-GCEYSCVNTDKSFACQCPEGHVLRSD-------------------------- 518

  Fly   401 YQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQGYLH-CENINECQDN 464
                   |..|..:|.|...|                                | ||:
  Rat   519 -------GKTCAKLDSCALGD--------------------------------HGCEH------- 537

  Fly   465 PCGENAICTDTVGSFVCTCKPDYT-GDPFRGCVDIDECTALDKPCGQHAVCENTVPGYNCKCPQG 528
                  .|..:..||||.|...|. .|..:.|...|.|.|:|..| :| :|.|:...|.|||.:|
  Rat   538 ------SCVSSEDSFVCRCFEGYVLRDDGKTCRREDVCQAVDHGC-EH-LCVNSGESYICKCLEG 594

  Fly   529 Y----DGKPDPKVACEQVDVNILCSSNFDCTNNAECIENQCFCLDGFEPIGSSCVDIDECRTHAE 589
            :    |||     .|.:.||   |.|          |::.|      |.|
  Rat   595 FRLAEDGK-----RCRRKDV---CKS----------IQHGC------EHI--------------- 620

  Fly   590 VCGPHAQCLNTPGSYGCECEAGYVGSPPRMACKQPCE 626
                   |:|...||.|.|..|:|.:.....||:..|
  Rat   621 -------CVNNGNSYLCRCSEGFVLAEDGRHCKRCTE 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699	13/35 (37%)
		EGF_CA	212..247	CDD:238011	8/34 (24%)
		EGF_CA	255..>286	CDD:214542	8/30 (27%)
		EGF_CA	298..331	CDD:238011	13/33 (39%)
		EGF_CA	338..373	CDD:238011	15/34 (44%)
		EGF_CA	413..456	CDD:238011	4/43 (9%)
		EGF_CA	457..490	CDD:238011	7/33 (21%)
		EGF_CA	497..>529	CDD:214542	12/31 (39%)
		EGF_CA	580..>612	CDD:214542	6/31 (19%)
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Matn2	XP_216941.8	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA2W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810