DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and Notch2

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_077334.2 Gene:Notch2 / 29492 RGDID:3188 Length:2471 Species:Rattus norvegicus


Alignment Length:2091 Identity:530/2091 - (25%)
Similarity:729/2091 - (34%) Gaps:692/2091 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 LKC---TNDCDKDGTKCT-HGACLNGVCHCNDGYGGCNCVDKDENECKQRPCDVFAHCTN--TLG 149
            |:|   ...|..:||..| |..  .|.|.|.:|:.|..|..:|  .|::..|.....|..  .||
  Rat    26 LQCRGGQEPCVNEGTCVTYHNG--TGYCRCPEGFLGEYCQHRD--PCEKNRCQNGGTCVTQAMLG 86

  Fly   150 SFTCTCFPGYRGNGFHCEDIDECQ----DPAIAARCVENAECCNLPA--HFLCKCKDGYEGDGEV 208
            ..||.|.||:.|        ::||    .|...:|..:|...|::.:  .:.|.|:.|:.|.   
  Rat    87 KATCRCAPGFTG--------EDCQYSTSHPCFVSRPCQNGGTCHMLSWDTYECTCQVGFTGK--- 140

  Fly   209 LCTDVDECRNPENCGPNALCTNTPGNYTCSCPDGYVGNNPYREGCQ-DVDECSYPNVCGPGAICT 272
            .|...|.|.: ..|...:.|::....::|.||.|..|     :.|. |::||..|..|..|..|.
  Rat   141 QCQWTDVCLS-HPCENGSTCSSVANQFSCRCPAGITG-----QKCDADINECDIPGRCQHGGTCL 199

  Fly   273 NLEGSYRCDCPPGYDGDGRSESGCVDQDECARTPCGRNADCLNT-DGSFRCLCPDGYSGDPMNGC 336
            ||.|||||.||.|:.|. ..:|..|   .||.:||.....|..| |.:..|.|..|:.|   :.|
  Rat   200 NLPGSYRCQCPQGFTGQ-HCDSPYV---PCAPSPCVNGGTCRQTGDFTSECHCLPGFEG---SNC 257

  Fly   337 E-DVDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQLGYGPGATDIAP 400
            | ::|:| .|:.|..|..||:...::.||||              ||                  
  Rat   258 ERNIDDC-PNHKCQNGGVCVDGVNTYNCRCP--------------PQ------------------ 289

  Fly   401 YQRTSGAGLACL-DIDEC-NQPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQGYLHC-ENINECQ 462
                 ..|..|. |:||| .||:.   |.....|.|..|.|.|:|.:|:.|.   .| |||::|.
  Rat   290 -----WTGQFCTEDVDECLLQPNA---CQNGGTCTNRNGGYGCVCVNGWSGD---DCSENIDDCA 343

  Fly   463 DNPCGENAICTDTVGSFVCTCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCE-NTVPG-YNCKC 525
            ...|...:.|.|.|.||.|.|.....|   ..|...|.|  :..||.:.|:|: |.:.| |.|.|
  Rat   344 FASCTPGSTCIDRVASFSCLCPEGKAG---LLCHLDDAC--ISNPCHKGALCDTNPLNGQYICTC 403

  Fly   526 PQGYDGKPDPKVACEQVDVNILCSSNFDCTNNAECIENQCFCLDGFEPIGSSCVDIDEC-RTHAE 589
            ||||.|                          |:|.|                 |:||| ..::.
  Rat   404 PQGYKG--------------------------ADCTE-----------------DVDECAMANSN 425

  Fly   590 VCGPHAQCLNTPGSYGCECEAGYVGSPPRMACKQPCEDVRCGAHAYCKPDQNEAYCVCEDGWTYN 654
            .|....:|:||.|::.|||..||.|  ||                            ||      
  Rat   426 PCEHAGKCVNTDGAFHCECLKGYAG--PR----------------------------CE------ 454

  Fly   655 PSDVAAGCVDIDECDVMHGPFGSCGQNATCTNSAGGFTCACPPGFSGDPHSKCVDVDECRTGASK 719
                    :||:||   |.  ..|..:|||.:..|||||.|.|||.| .|.: ::|:||::.   
  Rat   455 --------MDINEC---HS--DPCQNDATCLDKIGGFTCLCMPGFKG-VHCE-LEVNECQSN--- 501

  Fly   720 CGAGAECVNVPGGGYTCRCPGNTIADPDPSVRCVPIVSCSANEDCPGNSICDATKRCLCPEPNIG 784
                 .|||                                                        
  Rat   502 -----PCVN-------------------------------------------------------- 505

  Fly   785 NDCRHPCEALNCGAHAQCMLANGQAQCLCAPGYTGNSALAGGCN-DIDECRANPCAEKAICSNTA 848
                          :.||:....:.||||.||:||..     |. |||:|.:.||...|.|.:..
  Rat   506 --------------NGQCVDKVNRFQCLCPPGFTGPV-----CQIDIDDCSSTPCLNGAKCIDHP 551

  Fly   849 GGYLCQCPGGSSGDPYREGCITSKTVGCSDANPCATGETCVQ--DSYTGNSVCICRQGYERNSEN 911
            .||.|||..|.:      |.:..:.:...|.:||..|: |..  ||||    |||..||    ..
  Rat   552 NGYECQCATGFT------GTLCDENIDNCDPDPCHHGQ-CQDGIDSYT----CICNPGY----MG 601

  Fly   912 GQCQD-VDECSVQRGKPACGLNALCKNLPGSYECRCPQGHNGNPFIMCEICNTPECQCQSPYKLV 975
            ..|.| :|||.    ...|..:..|.:|...|:|.|..|.:|   :.||| |..:|        .
  Rat   602 AICSDQIDECY----SSPCLNDGRCIDLVNGYQCNCQPGTSG---LNCEI-NFDDC--------A 650

  Fly   976 GNSCVLSGCSSGQACPSGAECISIAGGVSYCACPKGYQTQPDGSC-VDVDECEERGAQLCAFGAQ 1039
            .|.| |.|     ||..|....|       |.|..|:..|   .| :|:|||   .:..|..||.
  Rat   651 SNPC-LHG-----ACVDGINRYS-------CVCSPGFTGQ---RCNIDIDEC---ASNPCRKGAT 696

  Fly  1040 CVNKPGSYSCHCPEG-YQGDAYNGLCALAQRKCAADRECAANEKCIQPGECVCPPPYFLDPQDNN 1103
            |:|....:.|.|||| :....|:                       |..||:             
  Rat   697 CINDVNGFRCMCPEGPHHPSCYS-----------------------QVNECL------------- 725

  Fly  1104 KCKSPCERFPCGINAKCTPS-DPPQCMCEAGFKGDPLLGC-TDEDECSHLPCAYGAYCVNKKGGY 1166
              .|||      |:..||.. ...:|:|:||:.|   :.| .|::||...||..|..|.|...||
  Rat   726 --SSPC------IHGNCTGGLSGYKCLCDAGWVG---INCEVDKNECLSNPCQNGGTCNNLVNGY 779

  Fly  1167 QCVCPKDYTGDPYKSGCIFESGTPKSKCLSN-DDCASNLACLEGSCVSPCSSLLCGSNAYCETEQ 1230
            :|.|.|.:.|               ..|..| |:||||....:|:|:...|...           
  Rat   780 RCTCKKGFKG---------------YNCQVNIDECASNPCLNQGTCLDDVSGYT----------- 818

  Fly  1231 HAGWCRCRVGYVKNGDGDCVSQCQDVICGDGALC--IPTSEGPTCKCPQGQLGNPFPGGSCS--T 1291
                |.|.:.|........::.|....|.:.|:|  .|..|..||.|..|     :.|..|:  .
  Rat   819 ----CHCMLPYTGKNCQTVLAPCSPNPCENAAVCKEAPNFESFTCLCAPG-----WQGQRCTVDV 874

  Fly  1292 DQCSAARPCGERQICINGRCKERCEGVVCGIGATCDRNNGKCICEPNFVGNPDLICMPPIEQAKC 1356
            |:| .::||....||.|.:....||                  |.|.|.|   :.|...|.....
  Rat   875 DEC-VSKPCMNNGICHNTQGSYMCE------------------CPPGFSG---MDCEEDINDCLA 917

  Fly  1357 SPGCGENAHCEYGLGQSRCACNPGTFGNPYEGCGAQSKNVCQPNSCGPNAECRAVGNHISCLCPQ 1421
            :| |.....|...:....|.|.||..|:..:    ...|.|....|.....|....|..:|.||.
  Rat   918 NP-CQNGGSCVDKVNTFSCLCLPGFVGDKCQ----TDMNECLSEPCKNGGTCSDYVNSYTCTCPA 977

  Fly  1422 GFSGNPYIGCQ-DVDECANKPCGLNAACLNRAGGFECLCLSGHAGNPYSSCQPIESKFC-QDANK 1484
            ||.|   :.|: ::|||....|.....|::....|.|||..|..|           .|| .|.|:
  Rat   978 GFHG---VHCENNIDECTESSCFNGGTCVDGINSFSCLCPVGFTG-----------PFCLHDINE 1028

  Fly  1485 CQCNERVECPEGYSCQKGQCKNLCSQASCGPRAICDAGNCICPMGYIGDPHDQVHGCSIRGQCGN 1549
            |..|   .|....:|..|                .....|.||:||                   
  Rat  1029 CSSN---PCLNSGTCVDG----------------LGTYRCTCPLGY------------------- 1055

  Fly  1550 DADCLHSEICFQLGKGLRKCVDACSKIQCGPNALCVSEDHRSSCICSDGFFGNPSN-LQVGCQP- 1612
                        .||..:..|:.||...|.....|..|..|..|:|..|:.|...: |.|.|:. 
  Rat  1056 ------------TGKNCQTLVNLCSPSPCKNKGTCAQEKARPRCLCPPGWDGAYCDVLNVSCKAA 1108

  Fly  1613 --ERTVPEEEDKCKSDQDCSRGYGCQASVNGIKECINLCSNVVCGPNELCKINPAGHA-ICNCAE 1674
              ::.||.|             :.||.|  ||  |||                 ||:. .|.|..
  Rat  1109 ALQKGVPVE-------------HLCQHS--GI--CIN-----------------AGNTHHCQCPL 1139

  Fly  1675 SYVWNPVVSSCEKPSLPDCTSDANCPDASACRPDVLGVLKCVAICDAFTCPANSVCVARQHQGRC 1739
            .|..    |.||: .|.:|.|:. |...:.|...:.|.                         ||
  Rat  1140 GYTG----SYCEE-QLDECASNP-CQHGATCSDFIGGY-------------------------RC 1173

  Fly  1740 DCLNGFVGNPNDRNGCQPAQKHHCRNHAECQESEACIK---------DESTQTLGCRPACDTVKC 1795
            :|:.|:.|     ..|: .:...|:|. .||....||.         ...|:.|.|....|....
  Rat  1174 ECVPGYQG-----VNCE-YEVDECQNQ-PCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCAG 1231

  Fly  1796 GPRAV----CVTNNHQAQCQCPPGPFAGDPYD-PFNGCQSVPC-----------VYNHDCP-PSQ 1843
            ||..:    ||.......|:|.|| |||:..: ..|.|.|.||           ..|:.|. .|.
  Rat  1232 GPHCLNGGQCVDRIGGYSCRCLPG-FAGERCEGDINECLSNPCSSEGSLDCIQLKNNYQCVCRSA 1295

  Fly  1844 MCNRMTHTCFDVCDEESCGDNAICLAEDH---RAVCQCPPGFKG----DPLPEVACTK------- 1894
            ...|...|..|||.::.|.:...|....:   ..:|:|||||.|    ....:|.|.:       
  Rat  1296 FTGRHCETFLDVCPQKPCLNGGTCAVASNVPDGFICRCPPGFSGARCQSSCGQVKCRRGEQCVHT 1360

  Fly  1895 --------------QGGCAAGTCHPSAICEVTPEGPV--CKCPPLFVGDAKSGGCRPDGQCPNGD 1943
                          :.|||:..|.....|....:.|.  |:|.|.|.|........|....|   
  Rat  1361 ASGPHCFCLNRKDCESGCASNPCQHGGTCYPQRQPPYYSCRCSPPFWGSHCESYTAPTSTPP--- 1422

  Fly  1944 ADCPANTICAGGVCQNPCDNACGSNA------ECKVINRKPVCSC--PLR-FQPISDTAKDGCAR 1999
            |.| .:..||.......||.||.|:|      :|.:....|..:|  .|| ::.|::...:.|  
  Rat  1423 ATC-LSQYCADKARDGICDEACNSHACQWDGGDCSLTMEDPWANCTSSLRCWEYINNQCDELC-- 1484

  Fly  2000 TISKCLTDVDCGGALCYNGQCRIACRNSQDCSDGESCLKNVCVVACLDHSQCASGLACVEGHCTI 2064
            ..::||.|         |.:|:   |||:.|...:         .|.||.:        :.||..
  Rat  1485 NTAECLFD---------NFECQ---RNSKTCKYDK---------YCADHFK--------DNHCDK 1520

  Fly  2065 GCRSNKECKQD 2075
            || :|:||..|
  Rat  1521 GC-NNEECGWD 1530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 10/30 (33%)
EGF_CA 212..247 CDD:238011 9/34 (26%)
EGF_CA 255..>286 CDD:214542 16/30 (53%)
EGF_CA 298..331 CDD:238011 10/33 (30%)
EGF_CA 338..373 CDD:238011 11/34 (32%)
EGF_CA 413..456 CDD:238011 16/44 (36%)
EGF_CA 457..490 CDD:238011 11/32 (34%)
EGF_CA 497..>529 CDD:214542 13/33 (39%)
EGF_CA 580..>612 CDD:214542 12/32 (38%)
EGF_3 676..702 CDD:289699 13/25 (52%)
EGF_CA 1022..1056 CDD:214542 14/34 (41%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
Notch2NP_077334.2 EGF_CA 109..143 CDD:238011 7/36 (19%)
EGF_CA 182..218 CDD:238011 18/36 (50%)
EGF_CA 260..296 CDD:238011 14/73 (19%)
EGF_CA 298..335 CDD:238011 15/42 (36%)
EGF_CA 415..454 CDD:238011 17/68 (25%)
EGF_CA 456..492 CDD:238011 20/41 (49%)
EGF_CA 495..530 CDD:238011 16/117 (14%)
EGF_CA 532..567 CDD:238011 15/40 (38%)
EGF_CA 570..604 CDD:238011 14/42 (33%)
EGF_CA 608..643 CDD:238011 11/41 (27%)
EGF_CA 645..679 CDD:238011 14/57 (25%)
EGF_CA 682..717 CDD:238011 14/37 (38%)
EGF_CA 757..793 CDD:238011 14/50 (28%)
EGF_CA 795..831 CDD:238011 12/50 (24%)
EGF_CA 873..909 CDD:238011 13/57 (23%)
EGF_CA 911..947 CDD:238011 9/36 (25%)
EGF_CA 949..985 CDD:238011 11/38 (29%)
EGF_CA 987..1022 CDD:238011 11/45 (24%)
EGF_CA 1025..1061 CDD:238011 14/85 (16%)
EGF_CA 1117..1147 CDD:238011 15/67 (22%)
EGF_CA 1151..1185 CDD:238011 10/64 (16%)
EGF_CA 1188..1223 CDD:238011 8/35 (23%)
EGF_CA 1225..1262 CDD:238011 12/37 (32%)
EGF_CA 1264..1302 CDD:238011 9/37 (24%)
EGF_CA <1312..1343 CDD:238011 9/30 (30%)
Notch 1423..1456 CDD:278494 10/33 (30%)
Negative regulatory region (NRR). /evidence=ECO:0000250 1425..1677 36/139 (26%)
Notch 1463..1497 CDD:278494 9/44 (20%)
Notch 1501..1534 CDD:278494 12/48 (25%)
NOD 1540..1591 CDD:284282
NODP 1619..1673 CDD:284987
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1788
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1794..1813
Ank_2 <1820..1907 CDD:289560
ANK repeat 1827..1874 CDD:293786
ANK 1 1827..1871
ANK 1872..1997 CDD:238125
ANK 2 1876..1905
ANK repeat 1877..1907 CDD:293786
Ank_2 1881..1974 CDD:289560
ANK 3 1909..1939
ANK 1938..2062 CDD:238125
ANK repeat 1943..1974 CDD:293786
ANK 4 1943..1972
Ank_2 1948..2040 CDD:289560
ANK repeat 1976..2007 CDD:293786
ANK 5 1976..2005
ANK repeat 2009..2040 CDD:293786
ANK 6 2009..2038
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2097..2116
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2380..2471
DUF3454 2381..2439 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 48 1.000 Domainoid score I11586
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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