DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Thbs2

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001162609.1	Gene:	Thbs2 / 292406	RGDID:	1310979	Length:	1172	Species:	Rattus norvegicus

Alignment Length:	672	Identity:	153/672 - (22%)
Similarity:	223/672 - (33%)	Gaps:	250/672 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 CQVNESTEYLQLFNLSKLCDG----TQDCFLGADELSKELKCTNDCDKDG--------TKCTHGA 108
            |.|..:|           |.|    |:.|.||        ||.....::|        :.|:...
  Rat   408 CDVTSNT-----------CLGPSIQTRTCSLG--------KCDTRIRQNGGWSHWSPWSSCSVTC 453

  Fly   109 CLNGVCH---CND---GYGGCNC--VDKDENECKQRPCDVFAHCT--NTLGSFTCTCFPGYRGNG 163
            .:..|..   ||.   ..||.||  ..::...|::.||.:....:  :...:.|.||..|.|
  Rat   454 GVGNVTRIRLCNSPVPQMGGKNCKGSGRETKACQRAPCPIDGRWSPWSPWSACTVTCAGGIR--- 515

  Fly   164 FHCEDIDECQDPAIAARCVENAECCNLPAHFLCKCKDGYEGD---GEV----LCT----DVDEC- 216
                               |....||.|       :..|.|.   |:|    :|.    .:|.|
  Rat   516 -------------------ERTRVCNSP-------EPQYGGKDCVGDVTEHQMCNKRSCPIDGCL 554

  Fly   217 RNPENCGPNALCTNTP-GNYTC-SCPDGYVGNNPYREGCQDVDECS-YPNVC---GPGAICTNLE 275
            .||  |.|.|.|.:.| |:::| |||.|::||..:   |:|:|||: ..::|   ...:.|.|..
  Rat   555 SNP--CFPGAKCNSFPDGSWSCGSCPVGFLGNGTH---CEDLDECAVVADICFSINKASRCVNTN 614

  Fly   276 GSYRC-DCPPGYDG---------DGRSESG-CVDQDECARTP--CGRNADCLN----TDGSFRCL 323
            ..:.| .|||.|.|         |.::|.. |..::.|....  |.::|:|:.    :|..::|.
  Rat   615 PGFHCLPCPPRYKGTQPFGIGLEDAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCE 679

  Fly   324 CPDGYSGDPMNGCEDVD---------ECATNNPCGLGAECVNLGGSFQC---RCPS--------- 367
            |..||:||.:...||.|         .||||             .::.|   .||.
  Rat   680 CQTGYAGDGLICGEDSDLDGWPNSNLVCATN-------------ATYHCVKDNCPKLPNSGQEDF 731

  Fly   368 -----GFVLEHD-------PHADQLPQPLNTQQLGYGPGAT----DIAPYQR--------TSGAG 408
                 |...:.|       ...|..|...|.:||.|.....    |..||..        .:|.|
  Rat   732 DKDGIGDACDEDDDNDGVSDEKDNCPLLFNPRQLDYDKDEVGDRCDNCPYVHNQAQIDTDNNGEG 796

  Fly   409 LAC-LDI---DECNQPDGVAKCGTNAKCINFPGSYRCLCPSGF-------QGQGY-LHCENINEC 461
            .|| :||   |..|:.|.                    ||..:       .|.|. .||:|   |
  Rat   797 DACSVDIDGDDVFNERDN--------------------CPYVYNTDQRDTDGDGVGDHCDN---C 838

  Fly   462 ----------QDNPCGENAICTDTVGSFVCTCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCEN 516
                      |||         |.||. .|....|...|..:.  :.|.|..:..  ...|..:|
  Rat   839 PLMHNPDQMDQDN---------DLVGD-QCDNNEDIDDDGHQN--NQDNCPYISN--SNQADHDN 889

  Fly   517 TVPGYNCKCPQGYDGKPDPKVAC------EQVDVN-----ILCSSNFDCTNNAE----CIENQC- 565
            ...|..|......||.||.:..|      :|.|.:     .:|..:||..|..:    |.||..
  Rat   890 DGKGDACDSDDDNDGVPDDRDNCRLVFNPDQEDSDGDGRGDICKDDFDNDNVPDIDDVCPENNAI 954

  Fly   566 -------FCLDGFEPIGSSCVD 580
                   |.:...:|.|::.:|
  Rat   955 TETDFRNFQMVPLDPKGTTQID 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699	7/30 (23%)
		EGF_CA	212..247	CDD:238011	16/37 (43%)
		EGF_CA	255..>286	CDD:214542	11/35 (31%)
		EGF_CA	298..331	CDD:238011	9/38 (24%)
		EGF_CA	338..373	CDD:238011	10/60 (17%)
		EGF_CA	413..456	CDD:238011	10/53 (19%)
		EGF_CA	457..490	CDD:238011	10/42 (24%)
		EGF_CA	497..>529	CDD:214542	6/31 (19%)
		EGF_CA	580..>612	CDD:214542	1/1 (100%)
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Thbs2	NP_001162609.1	TSPN	22..213	CDD:214560
		VWC	320..374	CDD:278520
		TSP_1	385..430	CDD:278517	9/40 (23%)
		TSP1	440..492	CDD:214559	10/51 (20%)
		TSP1	497..549	CDD:214559	14/80 (18%)
		EGF_3	652..691	CDD:289699	11/38 (29%)
		TSP3 repeat_1C	693..728	CDD:275367	10/47 (21%)
		TSP3 repeat_long	729..764	CDD:275366	5/34 (15%)
		TSP3 repeat_short	765..787	CDD:275365	5/21 (24%)
		TSP_3	789..823	CDD:280556	11/53 (21%)
		TSP3 repeat_long	789..823	CDD:275366	11/53 (21%)
		TSP3 repeat_short	824..846	CDD:275366	6/24 (25%)
		TSP3 repeat_long	847..884	CDD:275365	11/50 (22%)
		TSP_3	848..884	CDD:280556	11/49 (22%)
		TSP3 repeat_short	885..920	CDD:275366	9/34 (26%)
		TSP_3	922..951	CDD:280556	6/28 (21%)
		TSP_C	974..1171	CDD:283408	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910