DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Fbln5

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_006240521.1	Gene:	Fbln5 / 29158	RGDID:	2594	Length:	461	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	126/475 - (26%)
Similarity:	161/475 - (33%)	Gaps:	197/475 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 DENECKQR---------------PCDVFAHCTNTLGSFTCTCFPGY---RGNGFHCEDIDECQDP 175
            :...|:||               |.:....|||           |:   |..| .|.|||||:
  Rat    10 NSGHCRQRRMILTVTILALWLPHPGNAQQQCTN-----------GFDLDRQTG-QCLDIDECR-- 60

  Fly   176 AIAARCVENAECCNLPAHFLC-------------------------------------------K 197
            .|...|..:..|.|....:||                                           .
  Rat    61 TIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTSYSGPYPAAAPPVPASNYPTISRPLV 125

  Fly   198 CKDGYEGDGEVLCTDVDEC-RNPENCGPNALCTNTPGNYTCSCPDGYVGNNPYREG-CQDVDECS 260
            |:.||:.|....|.||||| .:...|.|..:|.||.|.|||||.|||.    ..|| |.|:|||.
  Rat   126 CRFGYQMDEGNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYW----LLEGQCLDIDECR 186

  Fly   261 YPNVCGPGAICTNLEGSYRCDCPPGYDGDGRSESGCVDQDECARTPCGRNADCLNTDGSFRCLCP 325
            | ..|  ..:|.|:.|||.|.|.||:                          .||.||
  Rat   187 Y-GYC--QQLCANVPGSYSCTCNPGF--------------------------TLNDDG------- 215

  Fly   326 DGYSGDPMNGCEDVDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQLG 390
                    ..|:||:||.|.|||  ...|||..|||.|||..|:.||.|
  Rat   216 --------RSCQDVNECETENPC--VQTCVNTYGSFICRCDPGYELEED---------------- 254

  Fly   391 YGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGF-QGQGYLH 454
                             |:.|.|:|||:..:.:.:    .:|:|.||||.|.||.|: ..:....
  Rat   255 -----------------GIHCSDMDECSFSEFLCQ----HECVNQPGSYFCSCPPGYVLLEDNRS 298

  Fly   455 CENINECQ--DNPCGENAICTDTVGSFVCTCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCEN- 516
            |::||||:  ::.|.....|.:..|.|.|.       ||.                    |||.
  Rat   299 CQDINECEHRNHTCTPLQTCYNLQGGFKCI-------DPI--------------------VCEEP 336

  Fly   517 --TVPGYNCKCPQGYDGKPD 534
              .:....|.||....|..|
  Rat   337 YLLIGDNRCMCPAENTGCRD 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699	7/31 (23%)
		EGF_CA	212..247	CDD:238011	19/35 (54%)
		EGF_CA	255..>286	CDD:214542	14/30 (47%)
		EGF_CA	298..331	CDD:238011	4/32 (13%)
		EGF_CA	338..373	CDD:238011	19/34 (56%)
		EGF_CA	413..456	CDD:238011	14/43 (33%)
		EGF_CA	457..490	CDD:238011	9/34 (26%)
		EGF_CA	497..>529	CDD:214542	6/34 (18%)
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Fbln5	XP_006240521.1	vWFA	<134..178	CDD:294047	21/47 (45%)
		cEGF	200..223	CDD:289433	13/63 (21%)
		EGF_CA	220..258	CDD:214542	22/72 (31%)
		FXa_inhibition	271..299	CDD:291342	10/31 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000