DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and Jag1

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_062020.2 Gene:Jag1 / 29146 RGDID:2937 Length:1219 Species:Rattus norvegicus


Alignment Length:1170 Identity:274/1170 - (23%)
Similarity:409/1170 - (34%) Gaps:375/1170 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LLSSAVHS---QYSQQPQPFKTNLRANSRFRGEVFYLNLENGYFGCQVNESTEYLQLFNLSKLCD 75
            ::..|.||   ..|:|.|..|.| ...:.|..:: .:..::.|:|            |..:|.| 
  Rat   151 IIEKASHSGMINPSRQWQTLKQN-TGIAHFEYQI-RVTCDDHYYG------------FGCNKFC- 200

  Fly    76 GTQDCFLGADELSKELKCTNDCDKDGTK-CTHG----ACLNGVCH--CNDGYGGCNCVDKDENEC 133
            ..:|.|.|          ...||::|.| |..|    .|...:|.  |:..:|.|          
  Rat   201 RPRDDFFG----------HYACDQNGNKTCMEGWMGPECNKAICRQGCSPKHGSC---------- 245

  Fly   134 KQRPCDVFAHCTNTLGSFTCTCFPGYRGNGFHCEDIDECQDPAIAARCVENAEC----CNLPAHF 194
             :.|.|             |.|..|::  |.:|:            :|:.:..|    ||.|...
  Rat   246 -KLPGD-------------CRCQYGWQ--GLYCD------------KCIPHPGCVHGTCNEPWQC 282

  Fly   195 LCKCKDGYEGDGEVLCTDVDECRNPENCGPNALCTNT-PGNYTCSCPDGYVGNNPYREGCQDVDE 258
            ||:...|    |::...|::.|...:.|.....|:|| |..|.||||:||.|.|     |:..:.
  Rat   283 LCETNWG----GQLCDKDLNYCGTHQPCLNRGTCSNTGPDKYQCSCPEGYSGPN-----CEIAEH 338

  Fly   259 CSYPNVCGPGAICTNLEGSYRCDCPPGYDGDGRSESGCVDQDECARTPCGRNADCLNTDGSFRCL 323
            ....:.|.....|......:.|:|.||:.|...|    .:.|:|:...|.....|.:....|:|:
  Rat   339 ACLSDPCHNRGSCKETSSGFECECSPGWTGPTCS----TNIDDCSPNNCSHGGTCQDLVNGFKCV 399

  Fly   324 CPDGYSGDPMNGCE-DVDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQ 387
            ||..::|   ..|: |.:||.. .||.....|.||..|:.|.|..|::                 
  Rat   400 CPPQWTG---KTCQLDANECEA-KPCVNARSCKNLIASYYCDCLPGWM----------------- 443

  Fly   388 QLGYGPGATDIAPYQRTSGAGLAC-LDIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQG 451
                                |..| ::|::|     :.:|..:|.|.:....|||:||.|:.|. 
  Rat   444 --------------------GQNCDININDC-----LGQCQNDASCRDLVNGYRCICPPGYAGD- 482

  Fly   452 YLHCE-NINECQDNPCGENAICTDTVGSFVCTCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCE 515
              ||| :|:||..|||.....|.:.:..|.|.|...::|:..:  :|||.|.  ..||...|.|.
  Rat   483 --HCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQ--LDIDYCE--PNPCQNGAQCY 541

  Fly   516 NTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTNNAECIENQCFCLDGFEPIGSSCVD 580
            |....|.||||:.|:||                        |...:::.|..        :.|..
  Rat   542 NRASDYFCKCPEDYEGK------------------------NCSHLKDHCRT--------TPCEV 574

  Fly   581 IDECRT--------------HAEVCGPHAQCLN-TPGSYGCECEAGYVGSPPRMACKQ---PCED 627
            ||.|..              .:.|||||.:|.: :.|.:.|:|..|:.|:    .|.:   .||.
  Rat   575 IDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSESGGKFTCDCNKGFTGT----YCHENINDCEG 635

  Fly   628 VRCGAHAYCKPDQNEAYCVCEDGWTYNPSDVAAGCV-DIDECDVMHGPFGSCGQNATCTNSAGGF 691
            ..|.....|....|...|:|.|||.      .|.|. :|::|.  ..|   |....||.:....|
  Rat   636 NPCTNGGTCIDGVNSYKCICSDGWE------GAHCENNINDCS--QNP---CHYGGTCRDLVNDF 689

  Fly   692 TCACPPGFSGDP-HSKCVDVDECRTGASKCGAGAECVN--------VPGG--GYTCRCPGNTIAD 745
            .|.|..|:.|.. ||:....||     :.|..|..|.:        .|||  |.||....|:...
  Rat   690 YCDCKNGWKGKTCHSRDSQCDE-----ATCNNGGTCYDEVDTFKCMCPGGWEGTTCNIARNSSCL 749

  Fly   746 PDPSVRCVPIVSCSANEDCPGNSICDATKRCLCPEPNIG-------NDCR-HPCEALNCGAHAQC 802
            |:|   |....:|..|.|         :..|:|.|...|       |||. |||  .|.|.   |
  Rat   750 PNP---CHNGGTCVVNGD---------SFTCVCKEGWEGPICTQNTNDCSPHPC--YNSGT---C 797

  Fly   803 MLANGQAQCLCAPGYTGNSALAGGCN-DIDECRANPCAEKAICSNTAGGYLCQCPGGSSGDPYRE 866
            :..:...:|.||||:.|..     |. :|:||:::|||..|.|.:...||.|.||.|.||....|
  Rat   798 VDGDNWYRCECAPGFAGPD-----CRININECQSSPCAFGATCVDEINGYQCICPPGHSGAKCHE 857

  Fly   867 GCITSKTVGCSDANPCATGETCVQDSYTGNSVCICRQGYERNSENGQCQDVDECSVQRGKPACGL 931
                            .:|.:|:    |...|.:....::        .|.:.|....|:.||. 
  Rat   858 ----------------VSGRSCI----TMGRVILDGAKWD--------DDCNTCQCLNGRVACS- 893

  Fly   932 NALCKNLPGSYECRCPQGHNGNPFIMCEICNTPECQCQSPYKLVGNSCVLSGCSSGQACPSGAEC 996
            ...|    |...|:..:||.                                     .||:|..|
  Rat   894 KVWC----GPRPCQLHKGHG-------------------------------------ECPNGQSC 917

  Fly   997 ISIAGGVSYCACPKGYQTQPDGSCVDVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYN 1061
            |.:.....:        .:|   |....||.....|           |....|.....||.:   
  Rat   918 IPVLDDQCF--------VRP---CTGAGECRSSSLQ-----------PVKTKCTSDSYYQDN--- 957

  Fly  1062 GLCALAQRKCAADRECAANEKCIQPG---ECVCPPPYFLDPQDNNKCKSPCERFPCGINAKCTPS 1123
                      .|:.....|::.:.||   |.:|.     :.::.|..|:....:  .|...|.||
  Rat   958 ----------CANITFTFNKEMMSPGLTTEHICS-----ELRNLNILKNVSAEY--SIYIACEPS 1005

  Fly  1124  1123
              Rat  1006  1005

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 6/28 (21%)
EGF_CA 212..247 CDD:238011 15/35 (43%)
EGF_CA 255..>286 CDD:214542 5/30 (17%)
EGF_CA 298..331 CDD:238011 8/32 (25%)
EGF_CA 338..373 CDD:238011 12/34 (35%)
EGF_CA 413..456 CDD:238011 13/42 (31%)
EGF_CA 457..490 CDD:238011 10/32 (31%)
EGF_CA 497..>529 CDD:214542 14/31 (45%)
EGF_CA 580..>612 CDD:214542 12/46 (26%)
EGF_3 676..702 CDD:289699 7/25 (28%)
EGF_CA 1022..1056 CDD:214542 5/33 (15%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
Jag1NP_062020.2 MNNL 32..107 CDD:400141
DSL 167..229 CDD:396134 18/86 (21%)
Important for interaction with NOTCH1. /evidence=ECO:0000250 199..207 2/8 (25%)
EGF_CA 296..334 CDD:238011 16/42 (38%)
EGF 340..370 CDD:394967 7/29 (24%)
EGF_CA 374..410 CDD:238011 9/38 (24%)
EGF_CA 412..447 CDD:238011 13/72 (18%)
EGF_CA 450..485 CDD:238011 13/42 (31%)
EGF_CA 487..523 CDD:238011 11/35 (31%)
EGF_CA 525..560 CDD:238011 17/60 (28%)
EGF_CA 629..665 CDD:238011 11/41 (27%)
EGF_CA 667..702 CDD:238011 11/39 (28%)
EGF_CA <714..740 CDD:238011 7/25 (28%)
EGF 748..777 CDD:394967 9/40 (23%)
EGF_CA 782..817 CDD:238011 15/44 (34%)
EGF_CA 820..855 CDD:238011 16/34 (47%)
VWC_out 863..930 CDD:214565 19/131 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1182..1219
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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