DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Nedd9

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001011922.1	Gene:	Nedd9 / 291044	RGDID:	1306276	Length:	833	Species:	Rattus norvegicus

Alignment Length:	909	Identity:	176/909 - (19%)
Similarity:	276/909 - (30%)	Gaps:	302/909 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  7622 STGG-------QVTGQTTATP-SEVRTTIG-VEESTLPSRSTDRTTPSESPETPTTLPSDFTTRP 7677
            :|||       .:.|:....| :.|:..|| |:|            || |.|.||..|.
  Rat    36 NTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPVQE------------PS-SHEQPTPGPM------ 81

  Fly  7678 HSDQTTESTRDVPTTRPFEASTPRPVTLETAVPSVTSETTTNVPIGSTVTSETTTNVP------I 7736
            |.:...:....||.::    :.||. |:....||..::....||.|.....:....||      |
  Rat    82 HQNFGQQKLYQVPNSQ----AAPRD-TIYQVPPSYQNQGIYQVPTGHGTPEQDVYQVPPSVQRNI 141

  Fly  7737 GSTGGQVAGQTTAPPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFTTRPHSEQTTES 7801
            |||.|...|:      :|.|.:||....:             .|.|:....|....|.| .||:.
  Rat   142 GSTNGPHLGK------KVITPVRVGHGYV-------------YEHPSRYQKDVYDVPPS-HTTQG 186

  Fly  7802 TRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQLTEQSTSS-----------PSE 7855
            ..|:|           |:|::..|.|        ||:    |:|..|....           ||.
  Rat   187 VYDIP-----------PSSVKGPVFS--------VPV----GELKPQGVYDIPPTQGVYAIPPSA 228

  Fly  7856 VRTTIRVEESTLPSRSTDRTFPSESPEKPTTLPSDFTTRPHLEQTTESTRDVLTTRPFETSTPSP 7920
            .|     :|:.|..:..|  ||                 |.::|..:     |.|||.......|
  Rat   229 CR-----DEAGLREKEYD--FP-----------------PPMKQDGK-----LDTRPEGVYDIPP 264

  Fly  7921 VSLETTVPSVTSETSTNVPIGSTGGQVTEQTTAPPSVRTTETIVKSTHPAVSPDTTIPSEIPATR 7985
            .|.:|    |..:..|..|..:.||       |.|..|..:::  |.|.|       ||::.
  Rat   265 TSTKT----VGKDLHTKFPCDAPGG-------AEPMARRHQSL--SLHHA-------PSQVG--- 306

  Fly  7986 VPLESTTRLYTDQTIPPGSTDRTTSS--------ERPDESTRLTSEESTETTRPVPTVSPRDAL- 8041
                           |.|.|......        |.|.||:...:.|..:....||..:|.||.
  Rat   307 ---------------PSGDTQSDAYDVPRGVQFLEVPTESSEKANLEERDGVYDVPLHNPADAKG 356

  Fly  8042 ETTVTSLITETTKTTSGGTPRGQVTERTTKSVSELTTGRSSDVVTERTMPSNISSTTTVFNNSEP 8106
            ...|...|...:.:::|.|.....|..|:...|.|:...|.|   :|.:
  Rat   357 SRDVVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPSQD---KRLL---------------- 402

  Fly  8107 VSDNLPTTISITVTDSPTTVPVPTCKTDYDCLDEQTCIGGQCISPCEYFTNLCTVQNLTIC--RT 8169
                                           ||..|.||..........|.:|::.:|...  |:
  Rat   403 -------------------------------LDPDTAIGKLYWLQQTLETGICSLMSLVTIDWRS 436

  Fly  8170 LNHTTKCYCDTDDDVNRPDCSMKAEI----GCASSDECPSQQACINALCVDPCTFNNPCSRNEDC 8230
            ..:..:...:....|::.:..::..:    |..::..|..:...:|.:       |....|.:|
  Rat   437 YGYMERHINEIRTAVDKVELFLREYLHFARGALANASCLPEPVLLNKM-------NRELQRVDD- 493

  Fly  8231 RVFNHQPLCSAEHGRTPGCEHC----------PPGANCDPTTGACIKANVT-------ITTITTK 8278
               :||.|....|    ....|          .|...||......:.|...       .|||:|.
  Rat   494 ---SHQILSQTSH----DLNECSWSLNVLAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTISTY 551

  Fly  8279 NSTSTKIPTKPRTTANP-NTGVKTTPTTTRVTTRNTTTTTTTTTTSSTSTESSTITSATNQT-SK 8341
            ..|..::        :| |:.:|..|.:...:...|.|.:..........:..........| ||
  Rat   552 AETLFRV--------DPGNSHLKNGPDSITNSIEYTHTGSQMQPLRPGDYKGQVHNKPLPPTLSK 608

  Fly  8342 NQKPDTESTTSHTDATRR---------YRDGENNITDTPTPRPTIQTTTLRGEGVMGDS--QRRS 8395
            .|.||..|    :|.:.|         :..|:......       |...|..|.:|..|  |...
  Rat   609 EQPPDCSS----SDGSERSWMDDYDYVHLQGKEEFERQ-------QKELLEKENIMKQSKAQLEH 662

  Fly  8396 TTTPKMKTTRLDTSNEVPDTTSPW-PIE-LPTTEGTT-----------TEVYNTMFAPVVNTTD 8446
            ....:.:....:.:..|.:..|.| |.: ||||..:.           .:...|.|..::|..|
  Rat   663 HQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNNSVGAQDRQLLCFYYDQCETHFISLLNAID 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395	83/367 (23%)
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572	23/93 (25%)
		DUF4758	7798..7979	CDD:292572	41/191 (21%)
		DUF4758	7946..8126	CDD:292572	32/188 (17%)
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Nedd9	NP_001011922.1	SH3_NEDD9	7..63	CDD:212935	6/26 (23%)
		Serine_rich_CAS	400..561	CDD:298275	31/230 (13%)
		DUF3513	620..827	CDD:288849	20/114 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910