| Sequence 1: | NP_001260032.1 | Gene: | dpy / 318824 | FlyBaseID: | FBgn0053196 | Length: | 22949 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_775960.4 | Gene: | CRB2 / 286204 | HGNCID: | 18688 | Length: | 1285 | Species: | Homo sapiens |
| Alignment Length: | 1594 | Identity: | 376/1594 - (23%) |
|---|---|---|---|
| Similarity: | 505/1594 - (31%) | Gaps: | 552/1594 - (34%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 104 CTHGACLNGV-CHCNDGYGGCNCVDKDENECKQRPCDVFAHCT----NTLGSFTCTCFPGYRGNG 163
Fly 164 FHCE-DIDECQDPAIAAR-CVENAECCNLPAHFLCKCKDGYEGDGEVLC-TDVDECRNPENCGPN 225
Fly 226 ALCTNTPGNYTCSCPDGYVGNNPYREGCQ-DVDEC-SYPNVCGPGAICTNLEGSYRCDCP-PGYD 287
Fly 288 GDGRSESGCVDQD-ECARTPCGRNADCLNTDGSFRCLCPDGYSGDPMNGCE-DVDECATNNPCGL 350
Fly 351 GAECVN-----LGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQLGYGPGATDIAPYQRTSGAGLA 410
Fly 411 CLDIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQGYLHC-ENINECQDNPCGENAICTD 474
Fly 475 TVGSFVCTCKPDYTGDPFRGC-VDIDECTALDKPCGQHAVCENTVPGYNCKCPQGYDGKPDPKVA 538
Fly 539 CEQVDVNILCSSNFDCT-NNAECIENQCFCLDGFEPIGSSCVDIDECRTHAEVCGPHAQCLNTPG 602
Fly 603 SYGCECEAGYVGSPPRMACKQPCEDVRCGAHAYCKPDQNEAYCVCEDGWTYNPSDVAAGCVDIDE 667
Fly 668 CDVMHGPFGSCGQNATCTNSAGGFTCACPPGFSGDPHSKCVDVDECRTGASKCGAGAECVNVPGG 732
Fly 733 G-------YTCRCPGNTIADPDPSVRCVPIVSCSANEDCPGNSICDATKRCLCPEPNIGNDCRHP 790
Fly 791 CEALNCGAHAQCMLANGQAQCLCAPGYTGNSALAGGCNDIDECRANPCAEK---AICSNTAGGYL 852
Fly 853 CQCPGGSS----GDPYREGCITSKTVGCSDANPCATGETCVQDSYTGNSVCICRQGYERNSENGQ 913
Fly 914 CQDVDECSVQRGKPACGLNALCKNLPGSYECRCPQGHNGNPFIMCEICNTPECQCQSPYKLVGNS 978
Fly 979 CVLSGCSSGQACPSGAECI--SIAG---GVSYCACPKGYQTQPDGSCVDVDECEERGAQLCAF-- 1036
Fly 1037 -GAQCVNKPGSYSCHCPEGYQGDAYNGLCALA----------QRKCAADRECAANEK-------- 1082
Fly 1083 CIQ----PGECVCPPPYFLDPQDNNKCKSPCE---RFPCGINAKCTPSDPPQCMCEAGFKGDPLL 1140
Fly 1141 GCTDEDECSHLPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSGCIFESGTPKSKCLSNDDC---AS 1202
Fly 1203 NLACL------EG-----SCVSPCSSLLCG--SNAYCETEQHAGWCRCRVG-------YVKNGDG 1247
Fly 1248 DCVSQCQDVICGDGALCIPTSEGPTCKCPQGQLGNPFPG-----GSCSTDQCSAARPCGERQ--- 1304
Fly 1305 ---------ICINGRCKERCEGVVCGIGATCDRNNGKCICEPNFVGNPDLICMP-------PIEQ 1353
Fly 1354 AKCSPGCGENAHCEYGLGQSRCACNPGTFGNPYEGCGAQSKNVCQPNSCGPNAECRAVGNHISCL 1418
Fly 1419 CPQGFSGNPYIGCQ-DVDECANKPCGLNAACLNRAGGFECLCLSGHAGNPYSSCQ-PIESKFCQD 1481
Fly 1482 ANKCQCNERVECPEGYSCQKGQCKNLCSQASCGPRAICDAGNCICPMGYIGDPHD------QVHG 1540
Fly 1541 CSIRGQC---GNDADCL-----HSEICFQLGKGL 1566 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| dpy | NP_001260032.1 | EGF_3 | 137..166 | CDD:289699 | 11/32 (34%) |
| EGF_CA | 212..247 | CDD:238011 | 12/34 (35%) | ||
| EGF_CA | 255..>286 | CDD:214542 | 14/32 (44%) | ||
| EGF_CA | 298..331 | CDD:238011 | 19/33 (58%) | ||
| EGF_CA | 338..373 | CDD:238011 | 14/39 (36%) | ||
| EGF_CA | 413..456 | CDD:238011 | 7/43 (16%) | ||
| EGF_CA | 457..490 | CDD:238011 | 10/32 (31%) | ||
| EGF_CA | 497..>529 | CDD:214542 | 15/31 (48%) | ||
| EGF_CA | 580..>612 | CDD:214542 | 7/31 (23%) | ||
| EGF_3 | 676..702 | CDD:289699 | 8/25 (32%) | ||
| EGF_CA | 1022..1056 | CDD:214542 | 9/36 (25%) | ||
| EGF_CA | 2227..2260 | CDD:238011 | |||
| EGF_CA | 2393..>2422 | CDD:214542 | |||
| DUF4758 | 4088..4282 | CDD:292572 | |||
| DUF4696 | 4127..4678 | CDD:292395 | |||
| DUF4758 | 4275..4448 | CDD:292572 | |||
| DUF4758 | 4377..4574 | CDD:292572 | |||
| DUF4758 | 4581..4754 | CDD:292572 | |||
| DUF4758 | 4683..4847 | CDD:292572 | |||
| DUF4758 | 4785..4964 | CDD:292572 | |||
| DUF4696 | 4841..5385 | CDD:292395 | |||
| DUF4758 | 4887..5098 | CDD:292572 | |||
| DUF4758 | 5193..5371 | CDD:292572 | |||
| DUF4758 | 5294..5487 | CDD:292572 | |||
| DUF4758 | 5445..5650 | CDD:292572 | |||
| DUF4758 | 5700..5877 | CDD:292572 | |||
| DUF4696 | 5756..6396 | CDD:292395 | |||
| DUF4758 | 5802..5979 | CDD:292572 | |||
| DUF4758 | 5964..6171 | CDD:292572 | |||
| DUF4758 | 6181..6360 | CDD:292572 | |||
| DUF4696 | 6339..6999 | CDD:292395 | |||
| DUF4758 | 6662..6839 | CDD:292572 | |||
| DUF4758 | 6764..6941 | CDD:292572 | |||
| DUF4758 | 6866..7045 | CDD:292572 | |||
| DUF4758 | 6968..7179 | CDD:292572 | |||
| DUF4696 | 7024..7569 | CDD:292395 | |||
| DUF4758 | 7172..7383 | CDD:292572 | |||
| DUF4696 | 7330..7964 | CDD:292395 | |||
| DUF4758 | 7400..7587 | CDD:292572 | |||
| DUF4758 | 7538..7707 | CDD:292572 | |||
| DUF4758 | 7798..7979 | CDD:292572 | |||
| DUF4758 | 7946..8126 | CDD:292572 | |||
| YppG | 18767..>18832 | CDD:290883 | |||
| Med25_SD1 | 18795..18955 | CDD:288132 | |||
| MISS | 19026..19258 | CDD:292450 | |||
| ZP | 22576..22811 | CDD:214579 | |||
| Zona_pellucida | <22714..22810 | CDD:278526 | |||
| CRB2 | NP_775960.4 | Required for maximum inhibition of APP amyloid-beta peptide secretion. /evidence=ECO:0000269|PubMed:20299451 | 1..350 | 127/401 (32%) | |
| EGF_CA | 108..144 | CDD:238011 | 18/43 (42%) | ||
| EGF_CA | 147..182 | CDD:238011 | 12/40 (30%) | ||
| EGF_CA | 184..221 | CDD:238011 | 17/43 (40%) | ||
| EGF_CA | 226..259 | CDD:238011 | 20/35 (57%) | ||
| EGF_CA | 321..356 | CDD:238011 | 11/37 (30%) | ||
| EGF_CA | 358..393 | CDD:238011 | 16/56 (29%) | ||
| Laminin_G_2 | 465..588 | CDD:280389 | 28/158 (18%) | ||
| LamG | 653..773 | CDD:238058 | 26/132 (20%) | ||
| EGF_CA | 812..842 | CDD:238011 | 10/33 (30%) | ||
| LamG | 900..1024 | CDD:304605 | 27/156 (17%) | ||
| EGF | 1060..1090 | CDD:278437 | 9/32 (28%) | ||
| Interaction with EPB41L5. /evidence=ECO:0000269|PubMed:17920587 | 1249..1285 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||