DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and GP2

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001007241.2	Gene:	GP2 / 2813	HGNCID:	4441	Length:	537	Species:	Homo sapiens

Alignment Length:	641	Identity:	121/641 - (18%)
Similarity:	187/641 - (29%)	Gaps:	232/641 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly 22353 DADCPSQKACLRGECVNPCNATQPCGVNAFCSVRDTL---PVRTMICECLEGYTGNPAVQCDKRS 22414
            |.||.:........|.:||.             ..||   |.|:     .|...|:..  |||..
Human    45 DLDCGAPGTPEAHVCFDPCQ-------------NYTLLDEPFRS-----TENSAGSQG--CDKNM 89

  Fly 22415 LCVIEKGFVRDVDGQCVCPPGTALDIYEYCTPCREEQGFRIDE---------SGHCVCALERGMV 22470
                 .|:.|.|....|....|.:.::.    |:.:....::.         :.|..||
Human    90 -----SGWYRFVGEGGVRMSETCVQVHR----CQTDAPMWLNGTHPALGDGITNHTACA------ 139

  Fly 22471 IDERGRC----------TCPIDLG----YRLTPRGECQPEEPPECTSNDQCADNRFCNL--DTKT 22519
             ...|.|          .||   |    |||        |..|.|       :.|:|.:  |..|
Human   140 -HWSGNCCFWKTEVLVKACP---GGYHVYRL--------EGTPWC-------NLRYCTVPRDPST 185

  Fly 22520 CEDPCLTKVCGVNAFCNAVNHRAQCQCITGYTGN------PDLHCNHTNFRTDFPRPDMVVSCLA 22578
            .||.| .|.|.....|.|:|....|.|......:      |.|.|.....:.      .|..||.
Human   186 VEDKC-EKACRPEEECLALNSTWGCFCRQDLNSSDVHSLQPQLDCGPREIKV------KVDKCLL 243

  Fly 22579 DGV----QVEIHITEPGFNGVLYVKGHS--------KDEECRRV-------------VNLAGETV 22618
            .|:    :|..::.:|..:.:|..:..:        :...||.:             ::|..:.:
Human   244 GGLGLGEEVIAYLRDPNCSSILQTEERNWVSVTSPVQASACRNILERNQTHAIYKNTLSLVNDFI 308

  Fly 22619 PRTEIFRVHFGSCGMQAVKDVASFVLVIQKHPKLVTYKAQAYNIKCVYQTGEKNVTLGFNVSMLT 22683
            .|..|..::| .|                         |...::|...|...:.:....|||:..
Human   309 IRDTILNINF-QC-------------------------AYPLDMKVSLQAALQPIVSSLNVSVDG 347

  Fly 22684 TAGTIANTGPPPICQMRIITNEGEEINSAEIGDNLKLQVDVEPATIYGG-------------FAR 22735
            ....|....   :.|.:..||..|       ||.::|.|:   :.:|.|             ..|
Human   348 NGEFIVRMA---LFQDQNYTNPYE-------GDAVELSVE---SVLYVGAILEQGDTSRFNLVLR 399

  Fly 22736 SCIAKTMEDNVQNEYLVTDENGCATDTSIFGNWEYNPDTNSLLASFNAFKFPSS-DNIRFQCNIR 22799
            :|.|...||...........|.|:.......:.|.|..::....|...|.|... |.:...|.|.
Human   400 NCYATPTEDKADLVKYFIIRNSCSNQRDSTIHVEENGQSSESRFSVQMFMFAGHYDLVFLHCEIH 464

  Fly 22800 VCFG---RCQPVNCGGYNAFGRRRRSIADNSTDATAIATNSGVEGQLREEI-TISSNAIL---TF 22857
            :|..   :||| :|.                            ..|:|.|: .|....:|   ..
Human   465 LCDSLNEQCQP-SCS----------------------------RSQVRSEVPAIDLARVLDLGPI 500

  Fly 22858 EKRSGQGLNDANIKPAAQRVEDICVSMVGLIIA---LVITALLALVAVAVAVSCWL 22910
            .:|..|.....|..|          |..|.::|   :::|.|||          ||
Human   501 TRRGAQSPGVMNGTP----------STAGFLVAWPMVLLTVLLA----------WL 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579	49/276 (18%)
		Zona_pellucida	<22714..22810	CDD:278526	25/112 (22%)
GP2	NP_001007241.2	ZP	229..480	CDD:214579	52/324 (16%)
GP2	NP_001007241.2	Zona_pellucida	358..478	CDD:278526	29/130 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910