DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Nup98

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001274093.1	Gene:	Nup98 / 269966	MGIID:	109404	Length:	1816	Species:	Mus musculus

Alignment Length:	1296	Identity:	270/1296 - (20%)
Similarity:	419/1296 - (32%)	Gaps:	324/1296 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  6490 STRDVPTTRPFEASTPSSASSGNNCSISYFRNHYKCSNRFNRSADR------TTPSESPETPTLP 6548
            ||....||..|..:|....:||.....|.|.:.......|..|..:      |:....|.|.|..
Mouse    13 STGGFGTTSTFGQNTGFGTTSGGAFGTSAFGSSNNTGGLFGNSQTKPGGLFGTSSFSQPATSTST 77

  Fly  6549 S-DFTTRPHSEQTTESTRDVPTT------------RP-----FEASTPSPASLETTVPSVTSETT 6595
            . .|.|...:..:...|....|:            :|     |..||.|.....||       .|
Mouse    78 GFGFGTSTGTSNSLFGTASTGTSLFSSQNNAFAQNKPTGFGNFGTSTSSGGLFGTT-------NT 135

  Fly  6596 TNVPIGSTGGQVTGQTTAPPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTILPSDFTTRPHSD 6660
            |:.|.|||.|.:.|.::...:...|||:..    |...||           |::.:..:
Mouse   136 TSNPFGSTSGSLFGPSSFTAAPTGTTIKFN----PPTGTD-----------TMVKAGVS------ 179

  Fly  6661 QTTESTRD--VPTTRPFEASTPRPVTLETAVPSVTLETTTNVPIGSTGGQVT----GQTTATPSE 6719
             |..||:.  :...:.:|:.:...:.||      ..:.....|....||..|    |.:.||.|
Mouse   180 -TNISTKHQCITAMKEYESKSLEELRLE------DYQANRKGPQNQVGGGTTAGLFGSSPATSS- 236

  Fly  6720 VRTTIRVEESTLPSRSTDRTTPSESPE-----TPTTLPSDFTTRP------HSDQTTESTRDVPT 6773
                    .:.|.|.||..:..|....     |.||   .|.|.|      .:.|||..     .
Mouse   237 --------ATGLFSSSTTNSAFSYGQNKTAFGTSTT---GFGTNPGGLFGQQNQQTTSL-----F 285

  Fly  6774 TRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTEQTTSSPSEVRTTIGLEESTLPSR-- 6836
            ::||..:|.:|              .|....|:|      .|...||  ..|:||...|..|:
Mouse   286 SKPFGQATTTP--------------NTGFSFGNT------STLGQPS--TNTMGLFGVTQASQPG 328

  Fly  6837 ----STDRTSPSESPETPTTLPSDFITRPHS-----DQTTESTRDVPTTRPFEASTPSPASLETT 6892
                :...||...:..|.|.|    ..:|::     ..|......:.|   |..||.|..|..||
Mouse   329 GLFGTATNTSTGTAFGTGTGL----FGQPNTGFGAVGSTLFGNNKLTT---FGTSTTSAPSFGTT 386

  Fly  6893 -------VPSVTSETTTNVPIGSTGGQVTEQTTSS-------PSEVRTTIGLEESTLPSRSTDRT 6943
                   .|::|..|.||.   |..|..|..:.||       ...:.|.:|....|.........
Mouse   387 SGGLFGNKPTLTLGTNTNT---SNFGFGTNNSGSSIFGSKPAAGTLGTGLGTGFGTALGAGQASL 448

  Fly  6944 SPSESPETPTTLPSDFITRPHSDQTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPI 7008
            ..:..|:....|.:.....|..:.:|..........|...:.|::::.:..|....|.:.|..|.
Mouse   449 FGNNQPKIGGPLGTGAFGAPGFNTSTAILGFGAPQAPVALTDPNASAAQQAVLQQHLNSLTYSPF 513

  Fly  7009 GSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTES 7073
            |.:  .:.....|.|.:....::   .|.|:.....|||:....||.  |:. ..||.:.|||.:
Mouse   514 GDS--PLFRNPMSDPKKKEERLK---PTNPAAQKALTTPTHYKLTPR--PAT-RVRPKALQTTGT 570

  Fly  7074 SR---------DVPTTQPFEASTPRPVTLQTAVLPVTSETTTNVPIGSTGGQVTEQTTSSPSEVR 7129
            ::         |.|:... .|..|:. :::..||...:.:....|:...
Mouse   571 AKSHLFDGLDDDEPSLAN-GAFMPKK-SIKKLVLKNLNNSNLFSPVNHD---------------- 617

  Fly  7130 TTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFESSTPRPVT 7194
                         |.|..:|||.||.....  .|.::|..:...:...|       :|...|..|
Mouse   618 -------------SEDLASPSEYPENGERF--SFLSKPVDENNQQDGED-------DSLVSRFYT 660

  Fly  7195 LETAVP-PVTSETTTNVPIGSTGGQVTEQTTPSPSEVRTTIR--IEESTFPSRS--TDR------ 7248
            ...|.| |.|.|:..|....|:..:.|.......:.:|..:.  .||::|...|  .||
Mouse   661 NPIAKPIPQTPESVGNKNNSSSNVEDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENN 725

  Fly  7249 -----------------TTPSE------SPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFESS 7290
                             |.||.      :.|....:.||||.......:.....||..|......
Mouse   726 AYHIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDD 790

  Fly  7291 TPRPVTLEIAV-------PPVTSETTTNVAIGSTGGQVTEQTT----SSP---SEVRTTIRVEES 7341
            .......|:.|       |||.........:...|...|::|:    .||   :::....|:|
Mouse   791 IVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLE-- 853

  Fly  7342 TLPSRSTDRTTPSESPETPTTL--PSDFTTRPHSDQTTESTRDVPTTRPFEAST-PSPASLETTV 7403
             ..||..........|||.:.:  .|.|:.....|...|.....|.|...:..| |.|.:.:.|.
Mouse   854 -AVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPPKTTSKKLKTAPLPPAGQATT 917

  Fly  7404 PSVTLETTTSVPMGSTGGQV--TGQTTAPPSEVRTTIRVEESTLP-SRSTDRTPPSESPETPTT- 7464
            ..:||....:.|..|...:|  .|:.....|::   :.:.:..:| |...:..|..:.|.:.:|
Mouse   918 FQMTLNGKPAPPPQSQSPEVEQLGRVVELDSDM---VDITQEPVPDSVLEESVPEDQEPVSASTH 979

  Fly  7465 LPSDFTTRPHSDQTTESS-----RDVPT-TQPFESSTPRPVTL-EIAVPPVTSETTTNVPIGSTG 7522
            :.|.....||..|..::|     .||.. .|.|.....:..|: ||..|        .:||.::.
Mouse   980 IASSLGINPHVLQIMKASLLVDEEDVDAMDQRFGHIPSKGETVQEICSP--------RLPISASH 1036

  Fly  7523 GQVTGQTTATPSEVRTTIGVEESTLPSRSTDRT--TPSESPE---TPTTLPSDFTTRPHSDQTTE 7582
            .          |:.|:.:|   ..|.|:....|  :||.|.:   ||               .|.
Mouse  1037 S----------SKSRSIVG---GLLQSKFASGTFLSPSASVQECRTP---------------RTS 1073

  Fly  7583 STRDVPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGSTGGQVTGQTTATPSEVRTTIG 7643
            |..::|:|.|:  |.|.|.:...||||...|    |.:.:.|  :..|....|.|...|.|
Mouse  1074 SRMNIPSTSPW--SVPLPLATVFTVPSPAPE----VQLKTVG--IRRQPGLVPLEKSITYG 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395	120/574 (21%)
		DUF4758	6662..6839	CDD:292572	43/199 (22%)
		DUF4758	6764..6941	CDD:292572	45/201 (22%)
		DUF4758	6866..7045	CDD:292572	37/192 (19%)
		DUF4758	6968..7179	CDD:292572	39/219 (18%)
		DUF4696	7024..7569	CDD:292395	124/620 (20%)
		DUF4758	7172..7383	CDD:292572	51/260 (20%)
		DUF4696	7330..7964	CDD:292395	75/333 (23%)
		DUF4758	7400..7587	CDD:292572	41/202 (20%)
		DUF4758	7538..7707	CDD:292572	29/111 (26%)
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Nup98	NP_001274093.1	FG repeats 1	1..156		35/149 (23%)
		Nucleoporin_FG	40..149	CDD:372653	26/115 (23%)
		GLEBS, interaction with RAE1. /evidence=ECO:0000250	157..213		13/83 (16%)
		FG repeats 2	214..480		69/314 (22%)
		Nucleoporin_FG	239..332	CDD:372653	29/122 (24%)
		Nucleoporin_FG	329..466	CDD:372653	30/146 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..535		4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..682		6/18 (33%)
		Nucleoporin2	740..880	CDD:367810	29/142 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..937		12/50 (24%)
		Nup96	1333..1622	CDD:371903
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910