DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Zfp512b

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001158069.1	Gene:	Zfp512b / 269401	MGIID:	2685478	Length:	869	Species:	Mus musculus

Alignment Length:	714	Identity:	155/714 - (21%)
Similarity:	233/714 - (32%)	Gaps:	234/714 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly 19165 HPTPAPQPGVVNIP-SVAQPVHPTYQPPVVERPAIYDVYYPPPPSRPGVINIPSPPRPVYPVP-Q 19227
            ||.|||:||.|:.| ::::||..: :|..|.:|.  .|..|...|:|  |.|..|.....|:| .
Mouse   167 HPLPAPKPGPVSRPVTISRPVGVS-KPIGVSKPV--TVGKPVGVSKP--IGISKPVTVSRPIPVT 226

  Fly 19228 QPIYVPAPVLHIPAPRPVIHNIP-SVPQPTYPHRNPPIQDVTYPAPQP-SPPVPGIVNIP---SL 19287
            :|:.|..| :.:..|.||...|| :.|.|...|. |..:.||...|.| :.|||  |:.|   |.
Mouse   227 KPVTVSRP-MQVSRPVPVTKPIPITKPVPLTKHM-PVTKLVTVSKPVPLTKPVP--VSRPIVVSK 287

  Fly 19288 PQPVSTPTSGVINIPS--------------QASPPISVPTPGIVNIPSIPQPTPQ-RPSPGIINV 19337
            |.|||.|.:...:||.              :|:...|.......::.:.|..:.| ||..|....
Mouse   288 PVPVSRPIAISRHIPPCKMVLLSKSENKTLRATGKNSNKKRAADSLDTCPILSKQARPENGAYGP 352

  Fly 19338 PSVPQPIPTAPSPGIINIPSVPQPLPSPTPGVINIPQQPTPPPLVQQPGIINIPSVQQP--STPT 19400
            .|:.|              ||..||.:...|         ..||:.:..:..|..|.||  ....
Mouse   353 SSMDQ--------------SVTFPLSTDPSG---------SRPLMGKEALRPIGPVSQPEEDPER 394

  Fly 19401 TQHPIQDVQYETQRPQPTPGVINIPSVSQPTYPTQKPSYQDTSYPTVQPKPPVSGIINIPSVPQP 19465
            |:|         :|.|.||          ..:..::||              :||...:..:.:.
Mouse   395 TKH---------RRKQKTP----------KKFTGEQPS--------------ISGTFGLKGLAKA 426

  Fly 19466 ----------------VPSLTPGVINLPSEPSYSAPIPKPGIINVPSIPEPIPSIPQNPVQEVYH 19514
                            ...:...|:..|...|..||.|         :..|.|..|:...|...|
Mouse   427 EDKARVHRSKKQEGSGSEEVRKKVLATPVTVSKEAPTP---------VAHPAPGGPEEQWQRAIH 482

  Fly 19515 DTQKPQAIPGVVNVPSAPQPTPGRPYYDVAKPDFEFNPCYPSPCGPYSHCHNRFGVAACVCLPNY 19579
              ::.:|:....||.:.......:.:.:|.....|...|        .||..:|...|.:   ||
Mouse   483 --ERGEAVCPTCNVVTRKTLVGLKKHMEVCHKLQEALKC--------QHCRKQFKSKAGL---NY 534

  Fly 19580 RG-TPPNCRPECVINSDCPSS--------------------LACINEKCRDPCPGSCAYNAVCRV 19623
            .. ...:.:|     :|..:|                    |.|..|.|      ..|::::...
Mouse   535 HTMAEHSAKP-----TDAEASEGGEQEERERLRKVLKQMGRLRCPQEGC------GAAFSSLMGY 588

  Fly 19624 HEHVPNC---YCQTGYTGNPFISCQRT--------------PIAPVQREPIEAKDPCYPSICG-- 19669
            ..|...|   .|:......|...|.:|              ..||...:|.: |.|....:.|
Mouse   589 QYHQRRCGKPPCEVDSPSFPCTHCGKTYRSKAGHDYHVRSEHTAPPPEDPTD-KIPEAEDLLGVE 652

  Fly 19670 --PN----------AVCN----------------NGKCSCIPEYRGDPYVGCRPEC-VLNTDCAR 19705
              |:          ||.:                ..|...:||.....|.  ||.. .||.....
Mouse   653 RTPSGRIRRTSAQVAVFHLQEIAEDELARDWTKRRMKDDLVPETARLNYT--RPGLPTLNPQLLE 715

  Fly 19706 D-KACIQQKCKNPCPGTC---------GLQALCHVYNHVATCSCPEGMQGDAFV---RCDPKPK 19756
            . |..:::|....||..|         ||:|      |:|:||     :||..|   ||...||
Mouse   716 AWKNEVKEKGHVNCPNDCCEAIYASVSGLKA------HLASCS-----KGDHLVGKYRCLLCPK 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450	33/95 (35%)
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Zfp512b	NP_001158069.1	PRK12323	<170..425	CDD:237057	80/319 (25%)
		C2H2 Zn finger	573..594	CDD:275368	5/26 (19%)
		C2H2 Zn finger	609..630	CDD:275368	2/20 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910