DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and GGT7

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_821158.2	Gene:	GGT7 / 2686	HGNCID:	4259	Length:	662	Species:	Homo sapiens

Alignment Length:	563	Identity:	103/563 - (18%)
Similarity:	170/563 - (30%)	Gaps:	174/563 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  4630 GQTTAPPSEFRTTIRVEESTLPSRSTDRTTPSESPETPTILPSDSTTRTYSDQTTESTRDVPTTR 4694
            |.....|..|..:.|::.  |||.|::..:...||                  ..|:.:|
Human    52 GDPDTDPDSFLKSARLQR--LPSSSSEMGSQDGSP------------------LRETRKD----- 91

  Fly  4695 PFEASTPSPASLE---TTVPSVTLETTTNVPIG-------------STGGQVTEQTTSSPSEVRT 4743
            ||.|:....:..:   |.:.:..|...|.|.:.             ..|..||:....      |
Human    92 PFSAAAAECSCRQDGLTVIVTACLTFATGVTVALVMQIYFGDPQIFQQGAVVTDAARC------T 150

  Fly  4744 TIRVEESTLPSRSADRTTPSE------SPETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEAST 4802
            ::.:|..:....|.|....:.      :|.: :.|....:...|..:..||     ....|..|.
Human   151 SLGIEVLSKQGSSVDAAVAAALCLGIVAPHS-SGLGGGGVMLVHDIRRNES-----HLIDFRESA 209

  Fly  4803 PSSASLETTVPSVTLETTTNVPIGSTG-----------------GQVTEQTTSSPSE----VRTT 4846
            |.:...||...|  .||...:.:|..|                 .||.....:...:    ....
Human   210 PGALREETLQRS--WETKPGLLVGVPGMVKGLHEAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDL 272

  Fly  4847 IRVEESTLPSRSADRTTPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEASTPSSASLE 4911
            .|.....||...::|...:..|.....||...:.||...:..    ||               |.
Human   273 ARALAEQLPPNMSERFRETFLPSGRPPLPGSLLHRPDLAEVL----DV---------------LG 318

  Fly  4912 TTVP-------SVTLETTTNVPIGSTGGQVTEQTTS--------------------SPSEVRT-- 4947
            |:.|       ::|||......  ..||.:||:..|                    ||....|
Human   319 TSGPAAFYAGGNLTLEMVAEAQ--HAGGVITEEDFSNYSALVEKPVCGVYRGHLVLSPPPPHTGP 381

  Fly  4948 ----TIRVEE----STLPSRSTDRTTPSESPETPTTLPSDFTTRPHSEQTTESTRDV-------- 4996
                .:.:.|    ::|.||.......:|:.:....|.|......:....|||..|:
Human   382 ALISALNILEGFNLTSLVSREQALHWVAETLKIALALASRLGDPVYDSTITESMDDMLSKVEAAY 446

  Fly  4997 -------------PTTRPFEA-STPSPASLETTVPS---VTLETTTNVPIGSTGGQVTEQTTSSP 5044
                         |....:|. ..|:.|.:....|.   |.:.::.|.|.||  |.:|      |
Human   447 LRGHINDSQAAPAPLLPVYELDGAPTAAQVLIMGPDDFIVAMVSSLNQPFGS--GLIT------P 503

  Fly  5045 SEVRTTIRVEESTLPSRSADRTTPS-ESPETPTTLPSDFITRT 5086
            |.:....::.:.:.|:|:|:.:.|| |:...|...|..|:..|
Human   504 SGILLNSQMLDFSWPNRTANHSAPSLENSVQPGKRPLSFLLPT 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395	10/47 (21%)
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572	24/139 (17%)
		DUF4758	4683..4847	CDD:292572	33/206 (16%)
		DUF4758	4785..4964	CDD:292572	43/236 (18%)
		DUF4696	4841..5385	CDD:292395	60/313 (19%)
		DUF4758	4887..5098	CDD:292572	51/263 (19%)
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
GGT7	NP_821158.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..90		11/57 (19%)
GGT7	NP_821158.2	G_glu_transpept	155..654	CDD:307247	80/429 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910