DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and SNED1

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:XP_011509233.1 Gene:SNED1 / 25992 HGNCID:24696 Length:1437 Species:Homo sapiens


Alignment Length:1451 Identity:322/1451 - (22%)
Similarity:458/1451 - (31%) Gaps:502/1451 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 SKLCDGTQDCFLGADELSKELKCTNDCDKDGTKCTHGACLNGVCHCNDGYGGCNCVDKDENECKQ 135
            :.:|...:.|..|.       ||.:||.......|        |.|..|:.|..| ..|.|||..
Human   293 TSVCLALRPCLNGG-------KCIDDCVTGNPSYT--------CSCLSGFTGRRC-HLDVNECAS 341

  Fly   136 RPCDVFAHCTNTLGSFTCTCFPGYRGNGFHCE------DIDECQDPAIAARC-VENAECCNLPAH 193
            :||.....||:.:.||.|.|..|:  .|..||      |..|||.   ..:| |||...      
Human   342 QPCQNGGTCTHGINSFRCQCPAGF--GGPTCETAQSPCDTKECQH---GGQCQVENGSA------ 395

  Fly   194 FLCKCKDGYEGDGEVLC-TDVDECRNPENCGPNALCTNTPGNYTCSCPDGY------VGNNPYRE 251
             :|.|:.||.|   ..| .|||:| :|:.|.....|.:..|||||.|.:.:      .|::|..:
Human   396 -VCVCQAGYTG---AACEMDVDDC-SPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPD 455

  Fly   252 GCQDVDECSYPNVCGPGAICTNLEGSYRCDCPPGYDG-DGRSESGCVDQDECARTPCGRNADCLN 315
            .|     .|.|  |..|..|.:.:..|.|:||.|:.| |.|...    .|:|   .|.....||.
Human   456 AC-----LSAP--CHNGGTCVDADQGYVCECPEGFMGLDCRERV----PDDC---ECRNGGRCLG 506

  Fly   316 TDGSFRCLCPDGYSGDPMNGCE---DVDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPH- 376
            .:.:. |.||.|:.|   ..||   ....|..|..|..|..|:..|||:.|.|       |..| 
Human   507 ANTTL-CQCPLGFFG---LLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVC-------HTDHN 560

  Fly   377 -ADQLPQPLNTQQLGYGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSYR 440
             :..||.|.::.                      .|.:...|:..|               .||.
Human   561 ASHSLPSPCDSD----------------------PCFNGGSCDAHD---------------DSYT 588

  Fly   441 CLCPSGFQGQGYLHCENINE--CQDNPCGENAICTDTVGSFVCTCKPDYTGDPFRGCVDI---DE 500
            |.||.||.|:   |||....  |...||.....|.:..|.:.|:|...:||   |.| :|   |.
Human   589 CECPRGFHGK---HCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTG---RHC-EIGKPDS 646

  Fly   501 CTALDKPCGQHAVCENTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTNNAECIENQC 565
            |.:  .||.....|.:.:..|.|.||.|:.|:                        :.|...:.|
Human   647 CAS--GPCHNGGTCFHYIGKYKCDCPPGFSGR------------------------HCEIAPSPC 685

  Fly   566 F---CLDGFEPIGSSCVDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYVGSPPRMACKQPCED 627
            |   |::     |.:|.|.|.                   .:.|.|:|||:|.            
Human   686 FRSPCVN-----GGTCEDRDT-------------------DFFCHCQAGYMGR------------ 714

  Fly   628 VRCGAHAYCKPDQN---------------EAYCVCEDGWTYN-PSDVAA-----------GCVDI 665
             ||.|...|.|.:.               .|...|:.|::.: ||.:..           .|::|
Human   715 -RCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEI 778

  Fly   666 DEC---DVMHGPFGSCGQNATCTNSAGGFTCACPPGFSGDPHSKC-VDVDECRTGASKCGAGAEC 726
            |||   ..:||        .:|.:...|:.|.|..|:.|   :.| ::.||||  |..|..|..|
Human   779 DECRSQPCLHG--------GSCQDRVAGYLCLCSTGYEG---AHCELERDECR--AHPCRNGGSC 830

  Fly   727 VNVPGGGYTCRCPGNTIADPDPSVRCVPIVSCSANEDCPGNSICDA---TKRCLCPEPNIGNDCR 788
            .|:| |.|.||||...:     .|.|...|....:..|.....|::   ...|:|||...|..|.
Human   831 RNLP-GAYVCRCPAGFV-----GVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCE 889

  Fly   789 ---HPCEALNCGAHAQCMLANGQAQCLCAPGYTGNSALAGGCNDIDECRAN---PCAEK------ 841
               .||.:..||....|:.:||...|.|..||||           ::|...   |.|.|      
Human   890 TVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTG-----------EDCAKELFPPTALKMERVEE 943

  Fly   842 ---AICSNTAGG-------------YLCQCPGGSSGDPYREGCITSKTVGCSDANPCATGETCVQ 890
               :|..|...|             |:      ||...||......:|.........|.|.    
Human   944 SGVSISWNPPNGPAARQMLDGYAVTYV------SSDGSYRRTDFVDRTRSSHQLQALAAGR---- 998

  Fly   891 DSYTGNSVCICRQGYERNSENGQCQDVDECSV----QRGKPACGLNALCKNLPGSYECRCPQGHN 951
             :|.     |.....:|||.|.  .|:...:|    .|.:|..|.                    
Human   999 -AYN-----ISVFSVKRNSNNK--NDISRPAVLLARTRPRPVEGF-------------------- 1035

  Fly   952 GNPFIMCEICNTPECQCQSPYKL--VGNSCVLSGCSSGQACPSGAECISIAGGVSYCACPKGYQT 1014
                   |:.|.........:.|  :.::.|           ||.. :||..       |:..:.
Human  1036 -------EVTNVTASTISVQWALHRIRHATV-----------SGVR-VSIRH-------PEALRD 1074

  Fly  1015 QPDGSCVDVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAY--NGLCA---------LAQ 1068
            |    ..|||...:|    ..|.|....|..:.......|.:|:.:  ..|..         |..
Human  1075 Q----ATDVDRSVDR----FTFRALLPGKRYTIQLTTLSGLRGEEHPTESLATAPTHVWTRPLPP 1131

  Fly  1069 RKCAADRECAANEKCI----QPGECVCPPPYFLDPQDNNKCKS-----------------PCERF 1112
            ....|.|..|.:...:    .||..:  ..|.::...:...||                 |..|:
Human  1132 ANLTAARVTATSAHVVWDAPTPGSLL--EAYVINVTTSQSTKSRYVPNGKLASYTVRDLLPGRRY 1194

  Fly  1113 PCGINAKCTPSDPPQCMCEAGFKGDPLLGCTDEDECSHLPCAYGAYCVNKKGGYQCVCPKDYTGD 1177
            ...:.|..:....||                 ..|.:||              |....|:|....
Human  1195 QLSVIAVQSTELGPQ-----------------HSEPAHL--------------YIITSPRDGADR 1228

  Fly  1178 PYKSG----CIFESGTPKSKC----LSNDDCA----------SNLACLEGSCV-----SPCSSLL 1219
            .:..|    .:.::..|.::.    |.||..|          |.|....|...     ||..:..
Human  1229 RWHQGGHHPRVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSELVDGRGRVSARFGGSPSKAAT 1293

  Fly  1220 CGS----NAYCETEQHAGWCRCRVGYV----KNGD---GDCVSQCQDVICGDGALCIPTSEGPTC 1273
            ..|    :|..|..:.|   ..||...    ::|.   |:....|.:..|.:|..|:|.::..:|
Human  1294 VRSQPTASAQLENMEEA---PKRVSLALQLPEHGSKDIGNVPGNCSENPCQNGGTCVPGADAHSC 1355

  Fly  1274 KCPQGQLGNPFPGGSCSTDQCSAARPCG---------------------------ERQICINGRC 1311
            .|..|     |.|..|.......:|||.                           .:.||.    
Human  1356 DCGPG-----FKGRRCELACIKVSRPCTRLFSETKAFPVWEGGVCHHVYKRVYRVHQDICF---- 1411

  Fly  1312 KERCEGVVCGIGATCDRNNGK 1332
            ||.||..  .:..|.:|...|
Human  1412 KESCEST--SLKKTPNRKQSK 1430

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699 10/28 (36%)
EGF_CA 212..247 CDD:238011 14/40 (35%)
EGF_CA 255..>286 CDD:214542 9/30 (30%)
EGF_CA 298..331 CDD:238011 9/32 (28%)
EGF_CA 338..373 CDD:238011 10/34 (29%)
EGF_CA 413..456 CDD:238011 11/42 (26%)
EGF_CA 457..490 CDD:238011 8/34 (24%)
EGF_CA 497..>529 CDD:214542 10/34 (29%)
EGF_CA 580..>612 CDD:214542 5/31 (16%)
EGF_3 676..702 CDD:289699 5/25 (20%)
EGF_CA 1022..1056 CDD:214542 8/33 (24%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
SNED1XP_011509233.1 NIDO 128..284 CDD:214712
EGF_CA 296..332 CDD:238011 12/50 (24%)
EGF_CA 335..371 CDD:238011 14/37 (38%)
EGF_CA 411..447 CDD:238011 13/36 (36%)
EGF_CA 455..488 CDD:238011 12/39 (31%)
EGF_CA 569..601 CDD:238011 12/71 (17%)
EGF_CA 609..640 CDD:238011 10/34 (29%)
EGF_CA 645..679 CDD:238011 11/59 (19%)
EGF_CA <688..717 CDD:238011 12/65 (18%)
Sushi 722..775 CDD:278512 7/52 (13%)
EGF_CA 778..813 CDD:238011 12/45 (27%)
EGF_CA 817..851 CDD:238011 17/41 (41%)
EGF_CA 854..889 CDD:238011 8/34 (24%)
fn3 932..1012 CDD:278470 18/95 (19%)
fn3 1031..1106 CDD:278470 19/128 (15%)
fn3 1130..1208 CDD:278470 11/79 (14%)
EGF_CA 1336..1367 CDD:238011 9/35 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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