DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and HMCN2

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001278744.1 Gene:HMCN2 / 256158 HGNCID:21293 Length:5079 Species:Homo sapiens


Alignment Length:485 Identity:140/485 - (28%)
Similarity:172/485 - (35%) Gaps:192/485 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   198 CKDGYEGDGE-VLCTDVDECR-NPENCGPNALCTNTPGNYTCSCPDGYV----GNNPYREGCQDV 256
            |.:|:|.|.: ..|.|.|||. .|..|  :..|.|.||.::|:||.|:.    ..|     |:||
Human  4633 CPEGFELDSQGAFCVDRDECSGGPSPC--SHACLNAPGRFSCTCPTGFALAWDDRN-----CRDV 4690

  Fly   257 DECSY-PNVCGPGAICTNLEGSYRC--DCPPGYD-GDGRSESGCVDQDECAR--TPCGRNADCLN 315
            |||:: .::|..|..|.||.|||||  ||.||:. .||   :||.|.|||..  ..|..|..|.|
Human  4691 DECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADG---AGCEDVDECLEGLDDCHYNQLCEN 4752

  Fly   316 TDGSFRCLCPDGYSGDPMNG----CEDVDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPH 376
            |.|..||.||.||.   |.|    |.||:|| ...|.....:|.||.||::|.||.|..|..|  
Human  4753 TPGGHRCSCPRGYR---MQGPSLPCLDVNEC-LQLPKACAYQCHNLQGSYRCLCPPGQTLLRD-- 4811

  Fly   377 ADQLPQPLNTQQLGYGPGATDIAPYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCI-------- 433
                                           |.||..::         :.|.|...:        
Human  4812 -------------------------------GKACTSLE---------RNGQNVTTVSHRGPLLP 4836

  Fly   434 ------NFPG-SY-----------------RCLCPSGFQGQGYLHCENINECQDNPCGENAICTD 474
                  :.|| ||                 |..||.||..|                  |.:|| 
Human  4837 WLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQ------------------NGVCT- 4882

  Fly   475 TVGSFVCTCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCENTVPGYNCKCPQGYDGKPDPKVAC 539
                                  |:|||...:. | ||| |.||...|.|.||.||          
Human  4883 ----------------------DLDECRVRNL-C-QHA-CRNTEGSYQCLCPAGY---------- 4912

  Fly   540 EQVDVNILCSSNFDCTNNAECIENQCFCLDGFEPIGSSCVDIDECRTHAEVCGPHAQCLNTPGSY 604
                 .:|                         |.|.:|.||:||...:..|||...|.||.|||
Human  4913 -----RLL-------------------------PSGKNCQDINECEEESIECGPGQMCFNTRGSY 4947

  Fly   605 GC---ECEAGYVGSPPRMACKQPCEDVRCG 631
            .|   .|.|.|...|....|.:.|.. .||
Human  4948 QCVDTPCPATYRQGPSPGTCFRRCSQ-DCG 4976

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011 14/39 (36%)
EGF_CA 255..>286 CDD:214542 18/33 (55%)
EGF_CA 298..331 CDD:238011 16/34 (47%)
EGF_CA 338..373 CDD:238011 15/34 (44%)
EGF_CA 413..456 CDD:238011 12/74 (16%)
EGF_CA 457..490 CDD:238011 3/32 (9%)
EGF_CA 497..>529 CDD:214542 15/31 (48%)
EGF_CA 580..>612 CDD:214542 16/34 (47%)
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
HMCN2NP_001278744.1 VWA_2 39..209 CDD:290253
IG_like 434..513 CDD:214653
Ig 442..503 CDD:299845
IG 524..604 CDD:214652
Ig 534..601 CDD:143165
I-set 608..692 CDD:254352
IGc2 621..684 CDD:197706
IG_like 712..782 CDD:214653
Ig 715..779 CDD:143165
Ig 785..869 CDD:299845
IG 792..879 CDD:214652
I-set 885..972 CDD:254352
IGc2 898..962 CDD:197706
IG 988..1063 CDD:214652
Ig 995..1062 CDD:299845
I-set 1079..1161 CDD:254352
IGc2 1088..1151 CDD:197706
I-set 1165..1246 CDD:254352
IGc2 1179..1236 CDD:197706
IG 1258..1340 CDD:214652
Ig 1266..1340 CDD:299845
IG 1354..1433 CDD:214652
IGc2 1360..1423 CDD:197706
IG 1446..1527 CDD:214652
IGc2 1453..1517 CDD:197706
IG 1540..1620 CDD:214652
Ig 1540..1620 CDD:299845
I-set 1632..1716 CDD:254352
IGc2 1641..1704 CDD:197706
IG 1727..1807 CDD:214652
IGc2 1734..1797 CDD:197706
Ig 1820..1893 CDD:299845
IG_like 1827..1891 CDD:214653
I-set 1895..1975 CDD:254352
Ig 1912..1975 CDD:143165
I-set 1986..2076 CDD:254352
IGc2 2001..2066 CDD:197706
Ig 2079..2169 CDD:299845
I-set 2080..2167 CDD:254352
I-set 2171..2261 CDD:254352
IGc2 2185..2251 CDD:197706
I-set 2273..2355 CDD:254352
Ig 2285..2352 CDD:143165
I-set 2367..2449 CDD:254352
Ig 2379..2449 CDD:299845
Ig 2452..2542 CDD:299845
IG_like 2462..2542 CDD:214653
IG 2558..2638 CDD:214652
IGc2 2565..2628 CDD:197706
IG 2656..2736 CDD:214652
IGc2 2663..2726 CDD:197706
IG_like 2770..2847 CDD:214653
IGc2 2773..2837 CDD:197706
IG 2862..2942 CDD:214652
Ig 2868..2942 CDD:299845
IG_like 2954..3034 CDD:214653
IGc2 2961..3024 CDD:197706
I-set 3038..3129 CDD:254352
IGc2 3056..3119 CDD:197706
I-set 3133..3221 CDD:254352
IGc2 3148..3208 CDD:197706
IG 3234..3318 CDD:214652
IGc2 3240..3306 CDD:197706
IG 3329..3410 CDD:214652
IGc2 3336..3400 CDD:197706
IG_like 3424..3499 CDD:214653
IGc2 3430..3489 CDD:197706
I-set 3503..3590 CDD:254352
IGc2 3518..3580 CDD:197706
I-set 3602..3683 CDD:254352
IGc2 3610..3673 CDD:197706
IG 3693..3774 CDD:214652
Ig 3693..3774 CDD:299845
Ig 3777..3859 CDD:299845
IG 3784..3867 CDD:214652
IG_like 3887..3958 CDD:214653
IGc2 3887..3948 CDD:197706
IG 3968..4048 CDD:214652
Ig 3979..4040 CDD:299845
I-set 4052..4139 CDD:254352
IGc2 4065..4129 CDD:197706
I-set 4143..4228 CDD:254352
IGc2 4157..4218 CDD:197706
I-set 4246..4317 CDD:254352
IGc2 4247..4309 CDD:197706
Ig 4322..4405 CDD:299845
I-set 4323..4409 CDD:254352
G2F 4411..4593 CDD:284812
FXa_inhibition 4652..4687 CDD:291342 12/41 (29%)
EGF_CA 4689..4732 CDD:214542 22/45 (49%)
EGF_CA 4733..4774 CDD:284955 18/43 (42%)
EGF_CA 4776..4815 CDD:284955 17/72 (24%)
EGF_CA 4883..4922 CDD:214542 20/81 (25%)
EGF_CA 4923..4963 CDD:214542 17/39 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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