DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and COL6A5

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001265227.1	Gene:	COL6A5 / 256076	HGNCID:	26674	Length:	2614	Species:	Homo sapiens

Alignment Length:	510	Identity:	115/510 - (22%)
Similarity:	145/510 - (28%)	Gaps:	200/510 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  8655 TECRC--LPGFLGNAYVQCLP-SQGCRSDSECDSSQACINGKCSSPCQCGAYALCDVVNHRGVCK 8716
            |.|:|  :||..|...:|.:. |||.:...                            .||
Human  1389 TFCKCPGIPGPHGTRGLQAMKGSQGLKGSR----------------------------GHR---- 1421

  Fly  8717 CPPGYNGNPKV-GCSPPQDPCDPNPCGLNALCELDNGNPICYCP-----KGLTGNPFKNCIPEGD 8775
               |.:|||.| |.:.||.               |.|  |..||     |||.|  |..  |:|.
Human  1422 ---GEDGNPGVRGDTGPQG---------------DKG--IAGCPGAWGQKGLKG--FSG--PKGG 1462

  Fly  8776 ECTPNPCGPNSGCRRVGGNPVCFCLPEYEGQ---------PPS--IPCELPSN--PCDPSPCGPN 8827
            .       .:.|...:.|...|...|..:|:         |.|  .|.:....  |.||...|.|
Human  1463 H-------GDDGIDGLDGEEGCHGFPGIKGEKGDPGSQGSPGSRGAPGQYGEKGFPGDPGNPGQN 1520

  Fly  8828 -----------------------TQCSVLSNGFSKCTCLPNYVESPNTIRGCV-EPINPCDPNPC 8868
                                   .|.|..|.|       ....|....:||.. ||.|   |.|.
Human  1521 NNIKGQKGSKGEQGRQGRSGQKGVQGSPSSRG-------SRGREGQRGLRGVSGEPGN---PGPT 1575

  Fly  8869 GT-GAICDSSRHPVCYCPDNKIGNPFRLCDKPAVTIELCQPGPCGRNAECYVAGNREECYCRSGY 8932
            || ||       .....|....|||.|..:|.:..    |.||.|........|:..    |.|.
Human  1576 GTLGA-------EGLQGPQGSQGNPGRKGEKGSQG----QKGPQGSPGLMGAKGSTG----RPGL 1625

  Fly  8933 VGDAYQGCREPSRTVCDPNPCGPNANCVVAGDGQTACVCPDGLSGDPTSVIGCHGYECQVDADCP 8997
            :|.  :|  ||..    |...||     |...||.      |..||.    |..||...
Human  1626 LGK--KG--EPGL----PGDLGP-----VGQTGQR------GRQGDS----GIPGYGQM------ 1661

  Fly  8998 NSKACMGYRCYDPCPGACGQGAHCQVEEHHPVCSCNSGLTGNPGIRCY-------ALDHPKKNPC 9055
            ..|...|.|.:   ||..||.....          |.|:.|.||.:.:       .|...:.:..
Human  1662 GRKGVKGPRGF---PGDAGQKGDIG----------NPGIPGGPGPKGFRGLALTVGLKGEEGSRG 1713

  Fly  9056 VPSPCGRNSECKLLNNRAVCSCIPGYLGDPQSGCQPECDINSDCGDTLSCINHKC 9110
            :|.|.|:..             |.|..|.|   ...:||:.....:...|...||
Human  1714 LPGPPGQRG-------------IKGMAGQP---VYSQCDLIRFLREHSPCWKEKC 1752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
COL6A5	NP_001265227.1	Nonhelical region	19..1394		2/4 (50%)
		vWFA	29..195	CDD:294047
		VWA	236..404	CDD:278519
		vWA_collagen	441..590	CDD:238749
		YfbK	445..>593	CDD:225187
		vWA_collagen	627..787	CDD:238749
		YfbK	813..>980	CDD:225187
		VWA	814..985	CDD:278519
		VWA	1005..1172	CDD:278519
		Collagen	1394..1447	CDD:189968	22/104 (21%)
		Triple-helical region	1395..1728		105/475 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1404..1693		95/418 (23%)
		Cell attachment site. /evidence=ECO:0000255	1430..1432		0/1 (0%)
		Collagen	1443..1520	CDD:189968	21/87 (24%)
		Collagen	1485..1576	CDD:189968	21/100 (21%)
		Collagen	1564..1623	CDD:189968	21/76 (28%)
		Collagen	1597..1657	CDD:189968	22/90 (24%)
		Collagen	1645..1730	CDD:189968	27/126 (21%)
		VWA	1759..1918	CDD:278519
		vWFA_subfamily_ECM	1962..2137	CDD:238727
		vWFA_subfamily_ECM	2290..2467	CDD:238727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910