back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Notch1

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001099191.1	Gene:	Notch1 / 25496	RGDID:	3187	Length:	2531	Species:	Rattus norvegicus

Alignment Length:	1983	Identity:	508/1983 - (25%)
Similarity:	718/1983 - (36%)	Gaps:	616/1983 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 CQVNESTEYLQLFNLSKLCDGTQDCFLGADELSKELKC-------TNDCDKDGTKC---THGACL 110
            |:|...||       :.:|.|   .|:|.       :|       :..|...|| |   .||..:
  Rat    37 CEVANGTE-------ACVCSG---AFVGQ-------RCQDPSPCLSTPCKNAGT-CYVVDHGGIV 83

  Fly   111 NGVCHCNDGYGGCNCVDKDENECKQRPCDVFAHC-TNTLGSFTCTCFPGYRGNGFHCEDIDEC-Q 173
            :..|.|..|:.|..|:....|.|...||.....| ..||..:.|.|.||:.|..  |:..|.| .
  Rat    84 DYACSCPLGFSGPLCLTPLANACLANPCRNGGTCDLLTLTEYKCRCPPGWSGKS--CQQADPCAS 146

  Fly   174 DPAIAARCVENAECCNLPAHFLCKCKDGYEGDGEVLC-TDVDEC-RNPENCGPNALCTNTPGNYT 236
            :|     |....:|....:.::|.|..|:.|.   .| .||:|| :||..|.....|.|..|:|.
  Rat   147 NP-----CANGGQCLPFESSYICGCPPGFHGP---TCRQDVNECSQNPGLCRHGGTCHNEIGSYR 203

  Fly   237 CSCPDGYVGNN---PY-------------------------------REGCQD-VDECSYPNVCG 266
            |:|...:.|.:   ||                               .:.|:: ||:|. .|.|.
  Rat   204 CACRATHTGPHCELPYVPCSPSPCQNGGTCRPTGDTTHECACLPGFAGQNCEENVDDCP-GNNCK 267

  Fly   267 PGAICTNLEGSYRCDCPPGYDGDGRSESGCVDQDECARTP--CGRNADCLNTDGSFRCLCPDGYS 329
            .|..|.:...:|.|.|||.:.|...:|    |.|||...|  |.....|.|:.|.:.|:|.:|::
  Rat   268 NGGACVDGVNTYNCRCPPEWTGQYCTE----DVDECQLMPNACQNGGTCHNSHGGYNCVCVNGWT 328

  Fly   330 GDPMNGCEDVDECATNNPCGLGAECVNLGGSFQCRCPSG--FVLEH-------DP-----HADQL 380
            |:..:  |::|:|| :..|..||.|.:...||.|.||.|  .:|.|       :|     :.|
  Rat   329 GEDCS--ENIDDCA-SAACFQGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCD-- 388

  Fly   381 PQPLNTQQLGYGPGATDIAPYQRTSG-AGLAC-LDIDECNQPDGVAKCGTNAKCINFPGSYRCLC 443
            ..|:|.:.:...|           || .|.|| .|:|||..  |...|....||:|..||:.|.|
  Rat   389 TNPVNGKAICTCP-----------SGYTGPACSQDVDECAL--GANPCEHAGKCLNTLGSFECQC 440

  Fly   444 PSGFQGQGYLHCE-NINECQDNPCGENAICTDTVGSFVCTCKPDYTGDPFRGC-VDIDECTALDK 506
            ..|:.|.   .|| ::|||..|||..:|.|.|.:|.|.|.|.|.|.|   ..| ::.|||.:  .
  Rat   441 LQGYTGP---RCEIDVNECISNPCQNDATCLDQIGEFQCICMPGYEG---VYCEINTDECAS--S 497

  Fly   507 PCGQHAVCENTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTNNAECIEN----QCFC 567
            ||..:..|.:.:..:.|:||:|:.|.     .| |.||: .|:|. .|.|.|:|::.    .|.|
  Rat   498 PCLHNGRCVDKINEFLCQCPKGFSGH-----LC-QYDVD-ECAST-PCKNGAKCLDGPNTYTCVC 554

  Fly   568 LDGFEPIGSSC-VDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYVGSPPRMACK---QPCEDV 628
            .:|:  .|:.| ||||||  ..:.| .:..|.:...::.|.|:.||.|.    .|:   ..|...
  Rat   555 TEGY--TGTHCEVDIDEC--DPDPC-HYGLCKDGVATFTCLCQPGYTGH----HCETNINECHSQ 610

  Fly   629 RCGAHAYCKPDQNEAYCVCEDGWTYNPSDVAAGC-VDIDECDVMHGPFGSCGQNATCTNSAGGFT 692
            .|.....|:...|...|:|..|.|      ...| :::|:|     ....| .:.||.:...|:.
  Rat   611 PCRHGGTCQDRDNYYLCLCLKGTT------GPNCEINLDDC-----ASNPC-DSGTCLDKIDGYE 663

  Fly   693 CACPPGFSGDPHSKC-VDVDECRTGASKCGAGAECVNVPGG-------GYTCRCPGNTIADPDPS 749
            |||.||::|   |.| |::|||        ||:.|.|  ||       |:|||||...   .||:
  Rat   664 CACEPGYTG---SMCNVNIDEC--------AGSPCHN--GGTCEDGIAGFTCRCPEGY---HDPT 712

  Fly   750 VRCVPIVS-CSANEDCPGNSICDATK--RCLCPEPNIGNDC---RHPCEALNCGAHAQCMLANGQ 808
              |:..|: |::| .|...:..|...  :|.|.....|.:|   .:.||:..|.....|......
  Rat   713 --CLSEVNECNSN-PCIHGACRDGLNGYKCDCAPGWSGTNCDINNNECESNPCVNGGTCKDMTSG 774

  Fly   809 AQCLCAPGYTGNSALAGGC-NDIDECRANPCAEKAICSNTAGGYLCQCP---GGSSGDPYREGCI 869
            ..|.|..|::|.:     | .:|:||.:|||..:..|.:...||.|.||   .|::.:.....|.
  Rat   775 YVCTCREGFSGPN-----CQTNINECASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCA 834

  Fly   870 TSKTVGCSDANPCATGETCVQDSYTGNSVCICRQGYERNSENGQ-CQ-DVDECSVQRGKPACGLN 932
            ||         ||.....|.:.....:..|:|..|::     || |: |::||.    |..|...
  Rat   835 TS---------PCKNSGVCKESEDYESFSCVCPTGWQ-----GQTCEIDINECV----KSPCRHG 881

  Fly   933 ALCKNLPGSYECRCPQGHNGNPFIMCEICNTPECQCQSPYKLVGNSCVLSGCSSGQACPSGAECI 997
            |.|:|..|||.|.|..|:.|.             .|:|..    :.|..:.|.:|.:|..|.
  Rat   882 ASCQNTNGSYRCLCQAGYTGR-------------NCESDI----DDCRPNPCHNGGSCTDGV--- 926

  Fly   998 SIAGGVSYCACPKGYQTQPDGSC-VDVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYN 1061
                ..::|.|..|:|   ...| .|::||   .:..|..||.|.:...||:|.||.|     :|
  Rat   927 ----NAAFCDCLPGFQ---GAFCEEDINEC---ASNPCQNGANCTDCVDSYTCTCPTG-----FN 976

  Fly  1062 GLCALAQRKCAADRECAANEKCIQPGECVCPPPYFLDPQDNNKCKSPCERFPCGINAKCTPSDPP 1126
            |:      .|..:........|...|.||                       .|||:.
  Rat   977 GI------HCENNTPDCTESSCFNGGTCV-----------------------DGINSF------- 1005

  Fly  1127 QCMCEAGFKGDPLLGCT-DEDECSHLPCAYGAYCVNKKGGYQCVCPKDYTG------------DP 1178
            .|:|..||.|.   .|. |.:||...||.:|..|.:..|.|:|.||:.|||            .|
  Rat  1006 TCLCPPGFTGS---YCQYDVNECDSRPCLHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSAP 1067

  Fly  1179 YKSGCIFESGTPKSKCLSND-----DCAS-----NLACLEGSCVSPCS------SLLCGSNAYCE 1227
            .|:|         .||...:     :|.|     |...|..||.....      :|||.....|.
  Rat  1068 CKNG---------GKCWQTNTQYHCECRSGWTGFNCDVLSVSCEVAAQKRGIDVTLLCQHGGLCV 1123

  Fly  1228 TEQHAGWCRCRVGYVKNGDGDCVSQCQDVICGDGALCIPTSEGPTCKCPQGQLGNPFPGGSCSTD 1292
            .|:...:|.|:.||..:...|.|.:|....|.:||.|.....|.:|||..|     :.|.:||.:
  Rat  1124 DEEDKHYCHCQAGYTGSYCEDEVDECSPNPCQNGATCTDYLGGFSCKCVAG-----YHGSNCSEE 1183

  Fly  1293 --QCSAARPCGERQICINGRCKERCEGVVCGIGATCDRNNGKCICEPNFVGNPDLICMPPIEQAK 1355
              :| .::||.....||:.....:|         :|.|......||.|...     |.||::.|.
  Rat  1184 INEC-LSQPCQNGGTCIDLTNTYKC---------SCPRGTQGVHCEINVDD-----CHPPLDPAS 1233

  Fly  1356 CSPGCGENAHCEYGLGQSRCACNPGTFGNPYEGCGAQSKNVCQPNSCGPNAECRAVGNHISCLCP 1420
            .||.|..|..|...:|...|.|.||..|...||
  Rat  1234 RSPKCFNNGTCVDQVGGYTCTCPPGFVGERCEG-------------------------------- 1266

  Fly  1421 QGFSGNPYIGCQDVDECANKPCGLNAA--CLNRAGGFECLCLSGHAGNPYSSCQPIESKFCQDAN 1483
                        ||:||.:.||.....  |:.|...|.|.|.:||.|.   .|:.:       .|
  Rat  1267 ------------DVNECLSNPCDPRGTQNCVQRVNDFHCECRAGHTGR---RCESV-------IN 1309

  Fly  1484 KCQCNERVECPEGYSCQKGQCKNLCSQASCGPRAICDAGNCICPMGYIGDPHDQVHGCSIRGQCG 1548
            .|:         |..|:.|   .:|:.||...|...    |.||.|:.|            ..|.
  Rat  1310 GCR---------GKPCRNG---GVCAVASNTARGFI----CRCPAGFEG------------ATCE 1346

  Fly  1549 NDADCLHSEICFQLGKGLRKCVDACSKIQCGPNALCVSEDHRSSCICSDGFFG------------ 1601
            |||                   ..|..::|.....|:|.....:|:|...|.|
  Rat  1347 NDA-------------------RTCGSLRCLNGGTCISGPRSPTCLCLGSFTGPECQFPASSPCV 1392

  Fly  1602 --NPSNLQVGCQPERTVPEEEDKCKSDQDCSRGYGCQASVNGIKECINLCSNVVCGPNELCKI-- 1662
              ||...|..|:|....|..  :|.          |.|..||:                ||.|
  Rat  1393 GSNPCYNQGTCEPTSESPFY--RCL----------CPAKFNGL----------------LCHILD 1429

  Fly  1663 ----NPAGHAICNCAESYVWNP---VVSSCEKPSLPDCTSDANCPDASACRPDVLGVLKCVAICD 1720
                ..||..|          |   :..:||   ||:|..||
  Rat  1430 YSFTGGAGRDI----------PPPQIEEACE---LPECQEDA----------------------- 1458

  Fly  1721 AFTCPANSVCVARQHQGRC-----DCLNGFVGNPND--RNGCQPAQ--KHHCRNHAECQ-ESEAC 1775
                 .|.||..:.:...|     ||...|    ||  :|..|..|  |:....|.:.| .|..|
  Rat  1459 -----GNKVCNLQCNNHACGWDGGDCSLNF----NDPWKNCTQSLQCWKYFSDGHCDSQCNSAGC 1514

  Fly  1776 IKD--ESTQTLG-CRPACDTVKCGPRAVCVTNNHQAQCQCPPGPFAGDPYDPFNGCQSVPCVYNH 1837
            :.|  :...|.| |.|..|       ..|..:.....|.              .||.|..|.::.
  Rat  1515 LFDGFDCQLTEGQCNPLYD-------QYCKDHFSDGHCD--------------QGCNSAECEWDG 1558

  Fly  1838 -DC-------------------PPSQMCNRMTH 1850
             ||                   ||.|:.|...|
  Rat  1559 LDCAEHVPERLAAGTLVLVVLLPPDQLRNNSFH 1591

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.