DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Bcar1

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001382051.1	Gene:	Bcar1 / 25414	RGDID:	2406	Length:	874	Species:	Rattus norvegicus

Alignment Length:	732	Identity:	167/732 - (22%)
Similarity:	238/732 - (32%)	Gaps:	251/732 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly 18940 PSYPAPNPPVNYPTQPSPQIPVQPGVINIPSAPLPTTPPQHPPVFIPSPESPSPAPKPGVINIPS 19004
            |:.|.|.||.. |.||.|.:|  .|| :.|..|.....|..|..:.|.|::....|.|.
  Rat    71 PAAPGPGPPAT-PPQPQPSLP--QGV-HTPVPPASQYSPMLPTAYQPQPDNVYLVPTPS------ 125

  Fly 19005 VTHPEYPTSQVPVYDVNYSTTPSPIPQKPGVVNIPSAPQ--------PVHPAPNPPVHEFNYPTP 19061
                   .:|..:|.     .|.|.||    ...|.|.|        |.|..|:|....:..|..
  Rat   126 -------KTQQGLYQ-----APGPNPQ----FQSPPAKQTSTFSKQTPHHSFPSPATDLYQVPPG 174

  Fly 19062 PAVPQQPGVLNIPSYPTPVAPTPQSPIYIP------SQEQPKPTTRPSVINVPS----------- 19109
            |..|.| .:..:|    |.|.|......:|      |.|..||   |:.:.||:
  Rat   175 PGSPAQ-DIYQVP----PSAGTGHDIYQVPPSLDTRSWEGTKP---PAKVVVPTRVGQGYVYEAS 231

  Fly 19110 -VPQPAYPTPQ---AP----VYDVNYPTSPSVIPHQPGVVNIPSVPLPAPPVKQRPVFVPSPVHP 19166
             ..|..|.||:   ||    :|||  |....::|:|.|                      ..|:.
  Rat   232 QAEQDEYDTPRHLLAPGSQDIYDV--PPVRGLLPNQYG----------------------QEVYD 272

  Fly 19167 TPAPQPGVVNIPSVAQPVHPTYQ-PPVVER-------PAIYDVYYPPPPSRPGVINIPSPP---R 19220
            ||   |..|..|:...|:...|. ||.||:       .::|||  ||..|:    ::|..|   .
  Rat   273 TP---PMAVKGPNGRDPLLDVYDVPPSVEKGLPPSNHHSVYDV--PPSVSK----DVPDGPLLRE 328

  Fly 19221 PVYPVPQQPIYV-PAPVLHIPAPRPVIHNIPSVPQPTYPHRNPPIQDVTYPAPQPSPPVPGIVNI 19284
            ..|.||  |.:. |.|  ..|...|:|...|       |..:||.:|| |..|   ||.|.:.::
  Rat   329 ETYDVP--PAFAKPKP--FDPTRHPLILAAP-------PPDSPPAEDV-YDVP---PPAPDLYDV 378

  Fly 19285 PSLPQPVSTPTSGVINIPSQASPPISVPTPG-IVNIPSIPQPTPQRPSPGIIN--VPSVPQPIP- 19345
            |                     |.:..|.|| :.::|......|:.....:|:  |.:||.|..
  Rat   379 P---------------------PGLRRPGPGTLYDVPRERVLPPEVADGSVIDDGVYAVPPPAER 422

  Fly 19346 TAPSPGIINIPSVPQPLPSPTPGVINIPQQ--------PTPPPLVQQPGIINIPSVQQPSTPTTQ 19402
            .||:.|        :.|.:.:.|.....|.        |...||..:..:..:..:||..:.|..
  Rat   423 EAPTDG--------KRLSASSTGSTRSSQSASSLEVVVPGREPLELEVAVETLARLQQGVSTTVA 479

  Fly 19403 HPIQDV--------QYETQRPQPTP------------GVIN------IPSVSQPTYPTQKPSYQD 19441
            |.:..|        ...|..||..|            |.::      ..:||..|:.:.:..:..
  Rat   480 HLLDLVGSASGPGGWRSTSEPQEPPVQDLKAAVAAVHGAVHELLEFARSAVSSATHTSDRTLHAK 544

  Fly 19442 TS---------YPTVQPKPPV--SG--------------IINIPSVPQPVPSLTPGVINLPSEPS 19481
            .|         |.|:.....|  ||              :....:||:....|...:....|...
  Rat   545 LSRQLQKMEDVYQTLVVHGQVLDSGRGGPGFTLDDLDRLVACSRAVPEDAKQLASFLHGNASLLF 609

  Fly 19482 YSAPIPKPGIINVPSIPEPIPSIPQNPVQEVYHDTQKPQAIPGVVNVPSAPQPTPGRPYYDVAKP 19546
            .....|.||       ||...|:..||       |.|..:|      .|.|.|:|         |
  Rat   610 RRTKAPGPG-------PEGSSSLHLNP-------TDKASSI------QSRPLPSP---------P 645

  Fly 19547 DFEFNPCYPSPCGPYSH 19563
            .|   ....||.|.|.:
  Rat   646 KF---TSQDSPDGQYEN 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132	6/14 (43%)
		MISS	19026..19258	CDD:292450	70/276 (25%)
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Bcar1	NP_001382051.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910