DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Umod

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_058778.2	Gene:	Umod / 25128	RGDID:	3940	Length:	644	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	128/484 - (26%)
Similarity:	165/484 - (34%)	Gaps:	183/484 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 DPAIAARCVE---NAECCNLPAHFLCKCKDGYEGDGEVLCTDVDECRNP--ENCGPNALCTNTPG 233
            |...|.||.|   ||.|........|.|:.|:.||| ::|.|:|||..|  .||. |::|.||.|
  Rat    27 DSPEARRCSECHDNATCVLDGVVTTCSCQAGFTGDG-LVCEDIDECATPWTHNCS-NSICMNTLG 89

  Fly   234 NYTCSCPDGYVGNNPYR----EGCQDVDECSYPNV--CGPGAICTNLEGSYRCDCPPGYDGDGRS 292
            :|.|||.||      :|    .||.||:||:...:  |...|.|.|.||||.|.||.||.|||..
  Rat    90 SYECSCQDG------FRLTPGLGCIDVNECTEQGLSNCHSLATCVNTEGSYSCVCPKGYRGDGWY 148

  Fly   293 ESGCVDQDECARTPCGRNADCLNTDGSFRCLCPD-------------------GYSGD-PMNG-- 335
               |    ||:...|....|||....|.:.:|.|                   |||.| .|:|
  Rat   149 ---C----ECSPGSCEPGLDCLPQGPSGKLVCQDPCNVYETLTEYWRSTDYGAGYSCDSDMHGWY 206

  Fly   336 -------------CEDVDECATNNPCGLGA--------------------ECVNLGGSFQCR-CP 366
                         |..|..|.|..|..|..                    .|.......|.: ||
  Rat   207 RFTGQGGVRMAETCVPVLRCNTAAPMWLNGSHPSSREGIVSRTACAHWSDHCCLWSTEIQVKACP 271

  Fly   367 SGFVLEHDPHADQLPQPLNTQQLGYGPGATDIAPYQRTSGAGLACLDIDECNQPDGV----AKCG 427
            .||      :...|.:|... .|.|                         |..|..|    .:||
  Rat   272 GGF------YVYNLTEPPEC-NLAY-------------------------CTDPSSVEGTCEECG 304

  Fly   428 TNAKCINFPGSYRCLCPSGFQ------GQGYLHCE------NINECQDNPCGENAICTDTVGSFV 480
            .:..|::..|.:||.|...|.      .:..|.||      ::::||....|...:       |:
  Rat   305 VDEDCVSDNGRWRCQCKQDFNITDVSLLEHRLECEANEIKISLSKCQLQSLGFMKV-------FM 362

  Fly   481 CTCKPDYTGDPFRGCVDIDE----------CTALDKPCG-------QHAVCENTVPGYNCKCPQG 528
                  |..|  |.|....|          ..|.|.|||       .||...||:
  Rat   363 ------YLND--RQCSGFSERGERDWMSIVTPARDGPCGTVLRRNETHATYSNTL---------- 409

  Fly   529 YDGKPDPKVACEQV--DVNILCSSNFDCT 555
                   .:|.|.:  |:||  ..||:|:
  Rat   410 -------YLASEIIIRDINI--RINFECS 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011	18/36 (50%)
		EGF_CA	255..>286	CDD:214542	15/32 (47%)
		EGF_CA	298..331	CDD:238011	12/51 (24%)
		EGF_CA	338..373	CDD:238011	11/55 (20%)
		EGF_CA	413..456	CDD:238011	12/52 (23%)
		EGF_CA	457..490	CDD:238011	5/32 (16%)
		EGF_CA	497..>529	CDD:214542	10/48 (21%)
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Umod	NP_058778.2	EGF_3	37..65	CDD:403986	9/28 (32%)
		EGF_CA	67..108	CDD:214542	20/47 (43%)
		EGF_3	120..149	CDD:403986	16/31 (52%)
		ZP	337..586	CDD:214579	28/127 (22%)
		ZP-N. /evidence=ECO:0000255	337..432		28/127 (22%)
		Flexible linker, important for secretion and polymerization into filaments. /evidence=ECO:0000250\|UniProtKB:P07911	433..456
		Internal hydrophobic patch (IHP). /evidence=ECO:0000255	457..467
		ZP-C. /evidence=ECO:0000255	468..592
		Essential for cleavage by HPN. /evidence=ECO:0000250\|UniProtKB:P07911	589..592
		Regulates polymerization into filaments. /evidence=ECO:0000250\|UniProtKB:P07911	601..610
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910