DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Nefm

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_058725.1	Gene:	Nefm / 24588	RGDID:	3160	Length:	845	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	95/514 - (18%)
Similarity:	154/514 - (29%)	Gaps:	120/514 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  3967 DFINVKYTV-MQLANQTEM----RTRFTDIEAENETTGP-YTTTTESYKTTKQLSSNPETETPTT 4025
            |.:|||..: :::|...::    .|||:..  ....||| ||....|...:.::.     :|...
  Rat   384 DLLNVKMALDIEIAAYRKLLEGEETRFSTF--SGSITGPLYTHRQPSVTISSKIQ-----KTKVE 441

  Fly  4026 LPSRPTTRPFTDQTTEFTSEIPTITPMEGSTPTPSHLETTVASITSESTTREVYTIKPFDRSTPT 4090
            .|.......|.::..|.|......:.||.:....:  |...||...|....|....:|....:|.
  Rat   442 APKLKVQHKFVEEIIEETKVEDEKSEMEDALTVIA--EELAASAKEEKEEAEEKEEEPEVEKSPV 504

  Fly  4091 PVSPDTTVPSITFETTTNIPIGTTRGQVTEQTTSSPSEKRTTIRVEESTLPSRSTDRTTPSESPE 4155
            . ||:.....              .|:..|:......|:.....|:........:::...||..|
  Rat   505 K-SPEAKEEE--------------EGEKEEEEEGQEEEEEEDEGVKSDQAEEGGSEKEGSSEKDE 554

  Fly  4156 TPTILPSDS-------TTRTYSDQTTES-------TRDVPTTRPFEASTPSPASLETTVPSVTLE 4206
            .......::       ......::.||.       ..::...:|.:|.:|        ||...:|
  Rat   555 GEQEEEGETEAEGEGEEAEAKEEKKTEGKVEEMAIKEEIKVEKPEKAKSP--------VPKSPVE 611

  Fly  4207 TTTNDPIGSTG--GQVTEQTTSSPSEVRTTIGLEESTLPSRSTDRTTPSESPETPTTLPSDFITR 4269
            .....|....|  .|..|:......||                    ..|||:....
  Rat   612 EVKPKPEAKAGKDEQKEEEKVEEKKEV--------------------AKESPKEEKV-------- 648

  Fly  4270 PHSDQTTESTRDVPTTRPFEASTPSSASLE----TTVPSVTLETTTNVPIGSTGGQVTEQTTSSP 4330
               ::..|..:|||..:..|:.....|..|    |....|:||..|.           |:.....
  Rat   649 ---EKKEEKPKDVPDKKKAESPVKEKAVEEMITITKSVKVSLEKDTK-----------EEKPQQQ 699

  Fly  4331 SEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFTTRPHSEQTT-------ESTRDVPT-- 4386
            .:|:.  :.||...........:|.||.:....:..:...:...||.|       |..:.|.|
  Rat   700 EKVKE--KAEEEGGSEEEVGDKSPQESKKEDIAINGEVEGKEEEEQETQEKGSGQEEEKGVVTNG 762

  Fly  4387 --TRPFEASTPSPASLETTVPSVTLETTTNVPIGSTGGQVTGQTTSSPSEVRTTIRVEE 4443
              ..|.|.......|.:..|.:..:|..|     |.||.  |.|......|..|.:|||
  Rat   763 LDVSPAEEKKGEDRSDDKVVVTKKVEKIT-----SEGGD--GATKYITKSVTVTQKVEE 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572	28/209 (13%)
		DUF4696	4127..4678	CDD:292395	63/348 (18%)
		DUF4758	4275..4448	CDD:292572	41/184 (22%)
		DUF4758	4377..4574	CDD:292572	20/78 (26%)
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Nefm	NP_058725.1	Filament_head	10..97	CDD:282575
		Filament	98..409	CDD:278467	5/24 (21%)
		Coil 1A	103..134
		Linker 1	135..147
		Coil 1B	148..246
		Linker 12	247..263
		Coil 2A	264..285
		Linker 2	286..289
		Coil 2B	290..410		6/25 (24%)
		Tail	411..844		87/487 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..782		59/366 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910