DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Amfr

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_035917.2	Gene:	Amfr / 23802	MGIID:	1345634	Length:	639	Species:	Mus musculus

Alignment Length:	321	Identity:	64/321 - (19%)
Similarity:	109/321 - (33%)	Gaps:	91/321 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  6500 FEASTPSS-ASSGNNCSISY----FRNHYKCSNRFNRSADRTTPSESPETPTLPSDFT----TRP 6555
            |..:||.. |.:.::|:|.:    ......|.:.|:.|..|:...:....||......    :|.
Mouse   322 FAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADGSRA 386

  Fly  6556 HSEQTTESTRD--VPTT----RP----------FEASTPSPASLETTVPSVTSET--TTNVPIGS 6602
            ..:...|:..:  ||..    ||          |:.|     .:.:.:||.:.|.  |||
Mouse   387 REDHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGS-----RIASWLPSFSVEVMHTTN----- 441

  Fly  6603 TGGQVTGQTTAPPSEVRTTIRVEESTLP-------------SRSTDRTT----------PSESPE 6644
                :.|.|.|..|::.......:...|             :||.:.||          |..:..
Mouse   442 ----ILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQMTRSVEITTDNILEGRIQVPFPTQR 502

  Fly  6645 TPTILP--SDFTTRPHSDQTTESTRDVPTTR-PFEASTPRPVTLETAVPSVTLETTTNVPIGSTG 6706
            :.::.|  :....||..| ..|....|.|.| |.:.|.....||:.:  .|.||     ||....
Mouse   503 SDSLRPALNSPVERPSPD-LEEGEASVQTERVPLDLSPRLEETLDFS--EVELE-----PIEVED 559

  Fly  6707 GQVTGQTTATPSEVRTTIRVE---------------ESTLPSRSTDRTTPSESPET-PTTL 6751
            .:..|...:..::.|..:.|:               :|:....:::|..|||...: |.||
Mouse   560 FEARGSRFSKSADERQRMLVQRKDDLLQQARKRFLNKSSEDDGASERLLPSEGTSSDPVTL 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395	64/321 (20%)
		DUF4758	6662..6839	CDD:292572	24/107 (22%)
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Amfr	NP_035917.2	HRD1	82..>378	CDD:227568	12/55 (22%)
		zf-RING_2	335..375	CDD:290367	8/39 (21%)
		CUE_AMFR	454..494	CDD:270604	5/39 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..531		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..620		6/25 (24%)
		VCP/p97-interacting motif (VIM). /evidence=ECO:0000250\|UniProtKB:Q9UKV5	618..636		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910