back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Synm

DIOPT Version :10

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_964001.2	Gene:	Synm / 233335	MGIID:	2661187	Length:	1561	Species:	Mus musculus

Alignment Length:	1386	Identity:	279/1386 - (20%)
Similarity:	449/1386 - (32%)	Gaps:	378/1386 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  6238 EVRTTIGVEESTLPSRSTDRTSPS------------ESPETPTTLPSDFITRPHSEQTTESTRDV 6290
            :|:|.:.:|.:|..:.....::|.            :.|...:...::.:.:..:|:.....|..
Mouse   299 QVKTGLSLEVATYRALLEGESNPEILIWTENIENVPQEPRNTSYRYTNSVLQRKNEKNLFPRRKT 363

  Fly  6291 PTTRPFEASTPSPASLKTTVPSVTSEATTNVPIGSTGGQVTEQTTSSPSEVRTTIRVE---ESTL 6352
                |:.|...|.||.......:.|:.||.|...:..|.:|.:.:||    .||...:   |.|:
Mouse   364 ----PWAAVNHSSASYSNWPGHLDSQTTTAVGSAARRGLLTSRHSSS----ATTSGQQKPLEKTI 420

  Fly  6353 PSRSTDRTTPSESPETPT-----TLPSDFTTRPHSEKTTESTRDVPTTRPFETSTPSPASLETTV 6412
            .||:..|      |.|||     ...:...|.||..| .|.|.|....|..|:
Mouse   421 SSRANLR------PVTPTHGFLRNTDAQMKTLPHRSK-VEGTGDTHARRATES------------ 466

  Fly  6413 PSVTLETTTSVPMGSTGGQVTGQTTAPPSEVRTTI---RVEESTLPSRSTDRTSPSESPETPTTL 6474
             .:|.|:.    .|..|....|..::.||..||.|   ::|......:..||:.
Mouse   467 -VITRESY----RGHQGHVAAGAVSSTPSNERTVILGKKLEAQATKEQERDRSG----------- 515

  Fly  6475 PSDFITRPHSEKTTESTRDVPTTRPFEASTPSSASSGNNCSISYFRN-HYKCSNRFNRSADRTTP 6538
                           ..|..|..:.|::...:|..          || .::...:.:|.|.:.
Mouse   516 ---------------VIRIKPEEKMFDSKEKASEE----------RNLRWEELTKLDRDARKR-- 553

  Fly  6539 SESPETPTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGST 6603
                |:..|..:...:...::.:...|:||.:  .|.|..|.|.:.|    :..::.....:..:
Mouse   554 ----ESRHLRDEAREKEALKERSVKEREVPIS--LEVSRGSRAEVST----IHLQSPGRKDVSHS 608

  Fly  6604 GGQVTGQTTAPPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTILPSDFTTRPHSDQTTESTRD 6668
            ||:     .|...|.|..:..:: |..|..:|.||.:.:....|.:...||..|.:::...|..|
Mouse   609 GGR-----EAETKETRFRLDTQD-TASSLQSDSTTETIAESIVTTILKQFTQSPGAEEEATSFPD 667

  Fly  6669 VPTTR------PFEASTPRPVTLETAVPSVT-------LETTTNVPIGSTGGQVTGQTTAT---- 6716
            ...|.      |.:..|...:.:|:.:..|.       |:...:..:...|  :.|::|.|
Mouse   668 TKVTYVDRKEFPGDGKTKTEIVVESKLTDVVDVSDEAGLDYLLSKDVKEVG--LKGKSTETMIGE 730

  Fly  6717 -----------PSEVRTTIRVEE--STLPSRSTDRTTPSESPETPTTLPSD-------------- 6754
                       .::|.....|||  |.:.....|.:||.:..|.....||.
Mouse   731 MINLGLKGREGRAKVVNVEIVEEPMSYIGGGKIDFSTPFQVEEVDDVSPSPKGFVEEEDGEGETH 795

  Fly  6755 --FTTRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETT-----------TNVPIGS 6806
              |:.|||.           |.:|           :.|:|.|...|.           .:.|...
Mouse   796 MAFSMRPHQ-----------TKQP-----------QGTIPHVEEVTEAGDSEGEQSYFVSTPDEY 838

  Fly  6807 TGGQVTEQTTSSPSEVRTTIGLEESTLPSRSTDRTSP------------SESP----ETPTTLPS 6855
            .||...|...|...::...   ||||:.....|..:.            .|.|    |.|.....
Mouse   839 PGGHDREDDGSVYGQIHIE---EESTIRYSWQDEIAQGTWRRKMRGDVGGEKPVKVLEVPALSLG 900

  Fly  6856 DFITRPH-SDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTEQTTS 6919
            ..|...| .::.:...|..||.  .|.....|....|::..|.|....:        |:.|
Mouse   901 GAIGSAHLKEEASGELRAEPTV--IEKEIKIPHEFHTSIKGVFSSEPRH--------QLVE---- 951

  Fly  6920 SPSEVRTTIGLEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSDQTTESTRDVPTTRPFEAS 6984
                   .||..|.|||.|..:..|.              :||....::...:.||...:
Mouse   952 -------VIGQLEETLPERMKEELSA--------------LTRQSQGESGSVSVDVKKVQ----- 990

  Fly  6985 TPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSS----------PSEVRTTIRVEESTLPS 7039
              |:|.     .||||....|:.......|:..:..|.          .|.||.::....|.:|
Mouse   991 --SAAG-----GSVTLMAEVNLSQTVDADQLDLEQLSRDEAGEIERAVESVVRESLAKRSSPVP- 1047

  Fly  7040 RSTDRTTPSESPE--------------TPTTLPSDF-TTRPHSDQTTESSRDVPTTQPFEASTPR 7089
            ||.||....|.|.              :|:....|. ...|.|||.....   |.:...|.::|.
Mouse  1048 RSPDREDGEEVPAGGILFKRWATRELYSPSGERDDAGQVSPSSDQRVTQG---PVSATVEVTSPT 1109

  Fly  7090 PVTLQTAVLPVTSETTTNVPIGSTGGQVTEQTT-SSPSEVRTTIRVEESTLPSRSTDRTTPSESP 7153
            .. :|:.||...|::..:|.:|.|....|||.| ..|    |...||.|...|.:......|.|.
Mouse  1110 GF-VQSHVLEDVSQSVRHVKLGPTEMWRTEQVTFGGP----TAQVVEVSGDFSEAVSSEGASRSV 1169

  Fly  7154 ETPTTLPSDFTTRPHSDQTTES---SRDVPTTQPF-ESSTPRPVTLETAVP-------PVTSETT 7207
            .       ..|..||..|.:..   ...|||.|.. ::..|.||.|.....       |.:..:.
Mouse  1170 R-------HITLGPHQSQVSTEVIFRGSVPTWQETGDTEKPGPVVLSVGADISGSGRMPGSERSH 1227

  Fly  7208 TNV------PIGST----GGQVTEQTTPSPSEVRTTIRI-------EESTFPSRSTDRT--TPSE 7253
            |..      |:..|    |...||::..|.:.|| ::::       ||..|.:...|:.  ...:
Mouse  1228 TEKEIRFQGPVSGTAQVGGNFATEESVGSQTFVR-SLQLGPKEGFREEIQFIAPIPDKVGWGEED 1291

  Fly  7254 SPETPTTLPSDFTTRPHSDQTTESTR-DVPTTRPFESSTPRPVTLEIAVPPVTSETTTNVAIGST 7317
            |..|..:|          ::.|...| |:...|...|....|.|||..    .||....|. ||.
Mouse  1292 SEHTKVSL----------ERATSIQRIDIVPQRYLASKQMAPQTLEFR----DSEDMVMVE-GSA 1341

  Fly  7318 GGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTR-------PHSDQ 7375
            |   |.|.|.:.:..|..::.:|:|. .|....:.|....:|...:.::.:..       |..::
Mouse  1342 G---TIQATHNFTSDREILQNKENTF-QRVISGSPPDSVGDTGAEVTANVSRSFRHIQIGPTEEE 1402

  Fly  7376 TTE---STRDVPTTRPFEASTPSPASLETTVPSVTLETTTSVPMGSTGGQVTGQTTAPPSEVRTT 7437
            .:|   :.|.|..|...:.|..||..:.                |:.||....:....|.|...|
Mouse  1403 PSEYFVTGRPVSKTFVLDGSVASPGLVG----------------GADGGSTPCRIALGPKETSFT 1451

  Fly  7438 IRVEES-TLPSRSTDRTPPSE 7457
            .:::.| |...||..|...||
Mouse  1452 FQMDLSDTRAIRSWTRDTGSE 1472

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.