DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Zp2

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_035905.1	Gene:	Zp2 / 22787	MGIID:	99214	Length:	713	Species:	Mus musculus

Alignment Length:	729	Identity:	134/729 - (18%)
Similarity:	226/729 - (31%)	Gaps:	244/729 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly 22299 VNGKCNDPCTTTALCAQDELCKVYHHRPQCACPPGTVPGKNGCESERH----IPICISD------ 22353
            ||.:..|  |||.:..:|::   ||.    .||        ..::|.|    |.:|..|
Mouse   112 VNIRVGD--TTTDVRYKDDM---YHF----FCP--------AIQAETHEISEIVVCRRDLISFSF 159

  Fly 22354 -------ADCPSQKACLRGECVNPCNATQPCGVNAFCSVRDTLPVRTMICECLEGYTGNPAVQCD 22411
                   || .:|.....|..|...|.|:          ...||::..|   ::|:  |..:...
Mouse   160 PQLFSRLAD-ENQNVSEMGWIVKIGNGTR----------AHILPLKDAI---VQGF--NLLIDSQ 208

  Fly 22412 KRSLCVIEKGFVRDVDGQCVCPPGTALDIYEYCTPCR-----------EEQGFRIDESGHCVCAL 22465
            |.:|.|                |..|..|..|.....           ...|.:|..|.|.:||.
Mouse   209 KVTLHV----------------PANATGIVHYVQESSYLYTVQLELLFSTTGQKIVFSSHAICAP 257

  Fly 22466 ERGMVID-ERGRCTCP--------IDLGYRLTPRGECQPEEPPECTSNDQCADNRFCNLDTKTCE 22521
            :..:..: .....|.|        :|.|....|..:.......:..:|....:.|...|.||..|
Mouse   258 DLSVACNATHMTLTIPEFPGKLESVDFGQWSIPEDQWHANGIDKEATNGLRLNFRKSLLKTKPSE 322

  Fly 22522 DPCLTKVCGVNAFCNAVNHRAQCQCITGYTGN-------PDLHCNHTNFRTDFPRPDMVVS---- 22575
            .      |....|     :.:..:....:.||       |:.||            :..||
Mouse   323 K------CPFYQF-----YLSSLKLTFYFQGNMLSTVIDPECHC------------ESPVSIDEL 364

  Fly 22576 CLADG---VQVEIHITEPGFNGVLYVKGHSKDEECRRVVNLAGETVPRTEIFRVHFGSCGMQAVK 22637
            |..||   .:|..|.|:|..|....:.|:|   .|:.:..:....:.|   |.:....||.:...
Mouse   365 CAQDGFMDFEVYSHQTKPALNLDTLLVGNS---SCQPIFKVQSVGLAR---FHIPLNGCGTRQKF 423

  Fly 22638 DVASFVLVIQKH------PKLVTYKAQAY--NIKCVYQTGEKNVTLGFNVSMLTTAGTIANTGP- 22693
            :....:...:.|      |..:.::...:  .::|.|          ...|||..|....:..|
Mouse   424 EGDKVIYENEIHALWENPPSNIVFRNSEFRMTVRCYY----------IRDSMLLNAHVKGHPSPE 478

  Fly 22694 ------PPICQMRIITNEG---------------------EEINSAEIGD-NLKLQVDVEPATIY 22730
                  |.:..::...::.                     .|:......| |:||.:|
Mouse   479 AFVKPGPLVLVLQTYPDQSYQRPYRKDEYPLVRYLRQPIYMEVKVLSRNDPNIKLVLD------- 536

  Fly 22731 GGFARSCIAKTMED--NVQNEYLVTDENGCATDTSIFGNWEYNPDTNSLLAS-------FNAFKF 22786
                 .|.|.:.||  :.....:|.|  ||..:...: ...::|..:|...|       ...|.|
Mouse   537 -----DCWATSSEDPASAPQWQIVMD--GCEYELDNY-RTTFHPAGSSAAHSGHYQRFDVKTFAF 593

  Fly 22787 PS-----SDNIRFQCNIRVCFGRCQPVNCGGYNAFGRRRRSIADNSTDATAIAT-NSGVEGQLRE 22845
            .|     |..|.|.|:..:|                 .:.|:.......|..|: .|..|....:
Mouse   594 VSEARGLSSLIYFHCSALIC-----------------NQVSLDSPLCSVTCPASLRSKREANKED 641

  Fly 22846 EITIS--SNAILTFEKRSGQGLNDANIKPAAQRV------EDICVSMVGLIIALVITALLALVAV 22902
            .:|:|  ...:|..:..|.:|     :.|::..:      :||....:|.:.|||.:      ||
Mouse   642 TMTVSLPGPILLLSDVSSSKG-----VDPSSSEITKDIIAKDIASKTLGAVAALVGS------AV 695

  Fly 22903 AVAVSCWLMAYRRR 22916
            .:...|:|  |::|
Mouse   696 ILGFICYL--YKKR 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579	50/288 (17%)
		Zona_pellucida	<22714..22810	CDD:278526	24/110 (22%)
Zp2	NP_035905.1	ZP	365..630	CDD:214579	52/312 (17%)
Zp2	NP_035905.1	Disordered. /evidence=ECO:0000269\|PubMed:26811476	462..484		5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910