DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and Tgoln2

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_033470.1	Gene:	Tgoln2 / 22135	MGIID:	105079	Length:	363	Species:	Mus musculus

Alignment Length:	428	Identity:	95/428 - (22%)
Similarity:	153/428 - (35%)	Gaps:	112/428 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  5902 DQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEVRTTI 5966
            |..:..:::.|.....::|||.|       |..:::..|..|   |.||  ||.:....:.:||:
Mouse    25 DADSGDSQNPPNQPSKQSSTPLP-------PESSNQVKTTRP---TDGQ--GQKSDKKDQDKTTL 77

  Fly  5967 GV----EESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSEQTTESTRDVPTTRPFEASTPSPA 6027
            ..    .||..|:.:||. |..:|...|             |:|....::  |.||.     ||.
Mouse    78 AAVSSKAESGPPTAATDH-SLGDSRRQP-------------EKTDAELKE--TARPL-----SPV 121

  Fly  6028 SLKTTVPSVTSEATTNVPIGS-----TGQRIGTTPSESPETPTTLPSDFTTRPHSEKTTESTRDV 6087
            :.|......:|...:..|.|.     ||...|.......:.||...|:..|...|.|:|:...|.
Mouse   122 NPKLEKSDQSSTEDSGKPTGGNSGKPTGGDSGKPTGGDSDKPTEAGSNKATEDDSGKSTKVDLDK 186

  Fly  6088 PTTRPFETSTPSPASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSR 6152
            ||::.|                                  .:..||...:|:.|.:.:::||
Mouse   187 PTSKIF----------------------------------PDTETSKTDKVQPTEKGQKATL--- 214

  Fly  6153 SADRTTPSESPETPTLPSDFTTRPH-SEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETT 6216
                |:.:||.||....|||:.:|. .::::|.|.||.|....|..|               |..
Mouse   215 ----TSKTESGETLAGDSDFSLKPEKGDKSSEPTEDVETKEIEEGDT---------------EPE 260

  Fly  6217 TNVPIGSTGGQVTGQTTAPPSEVRTTIGV--EESTLPSRSTDRTSPSESP-----ETPTTLPSDF 6274
            ...|:.....:|:|.:::...|...|..:  |:..|...|:..||...|.     .|...|.:..
Mouse   261 EGSPLEEENEKVSGPSSSENQEGTLTDSMKNEKDDLYKDSSGNTSAESSHFFAYLVTAAVLVAVL 325

  Fly  6275 ITRPHSEQ-----TTESTRDVPTTRPFEASTPSPASLK 6307
            ....|:::     ..|..|...|.|| :||.....:||
Mouse   326 YIAYHNKRKIIAFALEGKRSKVTRRP-KASDYQRLNLK 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395	95/428 (22%)
		DUF4758	5802..5979	CDD:292572	19/80 (24%)
		DUF4758	5964..6171	CDD:292572	46/215 (21%)
		DUF4758	6181..6360	CDD:292572	31/139 (22%)
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Tgoln2	NP_033470.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..302		80/365 (22%)
		PTZ00108	<34..261	CDD:240271	71/315 (23%)
		7 X 8 AA tandem repeats	133..188		13/54 (24%)
		Endocytosis signal. /evidence=ECO:0000250	356..359		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910