back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and FBN2

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001990.2	Gene:	FBN2 / 2201	HGNCID:	3604	Length:	2912	Species:	Homo sapiens

Alignment Length:	3288	Identity:	805/3288 - (24%)
Similarity:	1097/3288 - (33%)	Gaps:	1158/3288 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QPQPFKTNLRANSRFRGEVFYLNLENGYFGCQ-VNESTEYLQLFNLSKLCDGTQ----------D 79
            ||||.:         ||  |..|:..|  .|| |:|...      :..:|.|..          .
Human   257 QPQPCR---------RG--FIPNIRTG--ACQDVDECQA------IPGICQGGNCINTVGSFECR 302

  Fly    80 CFLGADELSKELKC--TNDCDKDGTKCTHGACLNGV----CHCNDGY----GGCNCVDKDENECK 134
            |..|..:.....||  .::|......|..|.|.|.|    |.|..||    .|..|:|:....|.
Human   303 CPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCF 367

  Fly   135 QRPCDVFAHCTNTL-GSFT---CTCFPG-------------------YR---------------- 160
            ...  |...|...| |..|   |.|.||                   ||
Human   368 SGL--VNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSA 430

  Fly   161 ---------------------------------GNGFH-----------------------CEDI 169
                                             ||||.                       .:.|
Human   431 GSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTI 495

  Fly   170 DECQDPAIAARCVENAECCNLPAHFLCKCKDGYEGDGEVLCTDVDEC-RNPENCGPNALCTNTPG 233
            |.|:..  |..|: |..|....:.:.|:|..||:.|....|.||||| .||  | .|..|.||||
Human   496 DICKHH--ANLCL-NGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNP--C-TNGDCVNTPG 554

  Fly   234 NYTCSCPDGYVGNNPYREGCQDVDECSYPNVCGPGAICTNLEGSYRCDCPPGYD--GDGRSESGC 296
            :|.|.|..|: ...|.::.|.|:|||....|......|.|.:||::|.|..|::  .||::   |
Human   555 SYYCKCHAGF-QRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKN---C 615

  Fly   297 VDQDECARTPCGRNADCLNTDGSFRCLCPDGYSGDPMNG--CEDVDECATNNPCGLGAECVNLGG 359
            ||.|||..|....|..|:|.||||:|:|..|:...| ||  |.|||||.|...| :...|:|..|
Human   616 VDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAP-NGRYCTDVDECQTPGIC-MNGHCINSEG 678

  Fly   360 SFQCRCPSGFVLEHDPHADQLPQPLNTQQLGYG-----------PGATDIA-------------P 400
            ||:|.||.|..:..|   .::....:.:...||           |||...:             |
Human   679 SFRCDCPPGLAVGMD---GRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEP 740

  Fly   401 YQR-------------TSGAGLAC--LDIDECN-QPDGVAKCGTNAKCINFPGSYRCLCPSGFQ- 448
            .|.             :||.|:..  .||:||. .||..|    |..|.|..|||||.|.||::
Human   741 CQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICA----NGICENLRGSYRCNCNSGYEP 801

  Fly   449 ---GQGYLHCENINECQDNP--CGENAICTDTVGSFVCTCKPDYTGDPFR----GCVDIDECTAL 504
               |:   :|.:|:||..|.  | :|.:|.:|.||:.|||.|.|.   ||    .|.||:||.:
Human   802 DASGR---NCIDIDECLVNRLLC-DNGLCRNTPGSYSCTCPPGYV---FRTETETCEDINECES- 858

  Fly   505 DKPCGQHAVCENTVPGYNCKCPQGYDGKPDPKVACEQVD----VNI---LCSSNFD-CTNNAEC- 560
             .|| .:..|.|.:..:||:|..|........:..:.:.    :||   .|..|.: .|..:||
Human   859 -NPC-VNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECC 921

  Fly   561 -------------IENQCFCLDGFEPI-GSSCVDIDECRTHAEVCGPHAQCLNTPGSYGCECEAG 611
                         .|....|..|...| |.:|.|::||.....|| |:.:|:|:.||:.|||..|
Human   922 ATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVC-PNGRCVNSKGSFHCECPEG 985

  Fly   612 YV--GSPPRMACKQPCEDVRCGAHAYCKPDQNEAY-----------CVCEDGWTY---------- 653
            ..  |:      .:.|.|:|. ...|.|.|::|..           |.|..|..:
Human   986 LTLDGT------GRVCLDIRM-EQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKP 1043

  Fly   654 ----------------NPSDVAAG---CVDIDECDVMHG--PFGSCGQNATCTNSAGGFTCACPP 697
                            |..||..|   ..||:||....|  .:|.      |.|:.|.|.|.|..
Human  1044 GTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGK------CRNTIGSFKCRCNS 1102

  Fly   698 GFSGDPHSK-CVDVDECRTGASKCGAGAECVNVPGGGYTCRCPGNTIADPDPSVRCVPIVSCSAN 761
            ||:.|...: |.|:||||.....||:|. |||.|
Human  1103 GFALDMEERNCTDIDECRISPDLCGSGI-CVNTP------------------------------- 1135

  Fly   762 EDCPGNSICDATKRCLCPEPNIGNDCRHPCEALNCGAHAQCMLANGQAQCLCAPGYTGNSALAGG 826
                                                         |..:|.|..||.....:...
Human  1136 ---------------------------------------------GSFECECFEGYESGFMMMKN 1155

  Fly   827 CNDIDECRANP-CAEKAICSNTAGGYLCQCPGGSSGDPYREGCITSKTVGCSDANPCATGETCVQ 890
            |.|||||..|| ......|.||.|.:.|.||.|....|.||.|:.......|| |.|..|: ||
Human  1156 CMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSD-NLCRNGK-CV- 1217

  Fly   891 DSYTGNSVCICRQGYERNSENGQCQDVDECSVQRGKPACGLNALCKNLPGSYECRCPQGHNGNPF 955
             :..|...|.|..||:...:...|.|:|||.:..|    |.:..|.|..|||||.|.:|
Human  1218 -NMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNG----GCDTQCTNSEGSYECSCSEG------ 1271

  Fly   956 IMCEICNTPECQCQSPYKLV--GNSCV-LSGCSSGQACPSGAECISIAGGVSY-CACPKGYQTQP 1016
                            |.|:  |.||. :..|.:......|.:|.:|.|  .| |.|..|:....
Human  1272 ----------------YALMPDGRSCADIDECENNPDICDGGQCTNIPG--EYRCLCYDGFMASM 1318

  Fly  1017 D-GSCVDVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYNGLCALAQRKCAADRECAAN 1080
            | .:|:||:|| :..:.:|.|| :|.|..||:.|||..||.
Human  1319 DMKTCIDVNEC-DLNSNICMFG-ECENTKGSFICHCQLGYS------------------------ 1357

  Fly  1081 EKCIQPGECVCPPPYFLDPQDNNKCKSPCERFPCGINAKCTPSDPP---QCMCEAGFKGDPLLGC 1142
               ::.|...|        .|.::|:.....  |.::|.|.  :.|   :|.|..|:.|:. :.|
Human  1358 ---VKKGTTGC--------TDVDECEIGAHN--CDMHASCL--NIPGSFKCSCREGWIGNG-IKC 1406

  Fly  1143 TDEDECSH--LPCAYGAYCVNKKGGYQCVCPKDYTGDPYKSGCIFESGTPKSKCLSNDDCASNL- 1204
            .|.||||:  ..|:..|.|||..|.|:|.|.:.:|||.:             .|...|:||.|:
Human  1407 IDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGF-------------TCSDVDECAENIN 1458

  Fly  1205 ACLEGSCVSPCSSLLCGSNAYCETEQHAGWCRCRVGYVKNGDGDCVSQCQDV-ICGDGALCI--P 1266
            .|..|.|::.       ..||        .|.|.:|:....|.   ..|||: .|....:|:  .
Human  1459 LCENGQCLNV-------PGAY--------RCECEMGFTPASDS---RSCQDIDECSFQNICVFGT 1505

  Fly  1267 TSEGP---TCKCPQG-QLGNPFPGGSCS-TDQCSAARPCGERQICINGRCKERCEGVVCGIGATC 1326
            .:..|   .|.|..| :|..  .||:|: .|:|  |.|..    |:||.|..           |.
Human  1506 CNNLPGMFHCICDDGYELDR--TGGNCTDIDEC--ADPIN----CVNGLCVN-----------TP 1551

  Fly  1327 DRNNGKCICEPNFVGNPDLICMPPIEQAKCSPGCGEN--AHC----------------EYGLGQS 1373
            .|.  :|.|.|:|..||..:            ||.:|  .:|                |.|:|.|
Human  1552 GRY--ECNCPPDFQLNPTGV------------GCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVS 1602

  Fly  1374 R--CACNPG-TFGNPYEGCGAQSKNVCQP-NSCGPNAECRAVGNHISCLCP--QGFSGNPY-IGC 1431
            |  |.|:.| .:|||.|        .|.| ||           .....|||  :||..||. |..
Human  1603 RSSCCCSLGKAWGNPCE--------TCPPVNS-----------TEYYTLCPGGEGFRPNPITIIL 1648

  Fly  1432 QDVDECANKPCGL--NAACLNRAGGFECLCLSGHAGNPYSSCQPIESKFCQDANKCQCNERVECP 1494
            :|:|||...| ||  ...|:|..|.|:|.|..|:    |.|   .:::.|:|.::|..:..|
Human  1649 EDIDECQELP-GLCQGGNCINTFGSFQCECPQGY----YLS---EDTRICEDIDECFAHPGV--- 1702

  Fly  1495 EGYSCQKGQCKNLCSQASCGPRAICDAGN--CICPMGYIGDPHDQV---HGC-----SIRGQCGN 1549
                |..|.|.|             ..||  ||||..|:     ||   |.|     |...:..|
Human  1703 ----CGPGTCYN-------------TLGNYTCICPPEYM-----QVNGGHNCMDMRKSFCYRSYN 1745

  Fly  1550 DADCLHSEICFQLGKGLRKCVDACSKI---QCGPNALCVSEDHRSSCICSDGFFGNPSNLQVGCQ 1611
            ...| .:|:.|.:.|.:..|.....|.   .|.|.....:.|.::.|       ||.........
Human  1746 GTTC-ENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC-------GNIPGFTFDIH 1802

  Fly  1612 PERTVPEEEDKCKSDQDCSRGYGCQASVNGIKECINLCSNVVCGPNELCKINPAGHAICNCAESY 1676
            ..:.|  :.|:|                   ||...:|:|.||       ||..|...|.|...:
Human  1803 TGKAV--DIDEC-------------------KEIPGICANGVC-------INQIGSFRCECPTGF 1839

  Fly  1677 VWNPVVSSCEKPSLPDCTSDANCPDASACRPDVLGVLKCVAICDAFTCPANSVCVARQHQGRCDC 1741
            .:|.::..||  .:.:|::..|                        .|..|:.|:......||:|
Human  1840 SYNDLLLVCE--DIDECSNGDN------------------------LCQRNADCINSPGSYRCEC 1878

  Fly  1742 LNGFVGNPN----DRNGCQPAQKHHCRNHAEC---QESEACI-----KDESTQTLGCRPA--CDT 1792
            ..||..:||    |||.|  .:..:..:|..|   |.|..||     |....||: |...  |:.
Human  1879 AAGFKLSPNGACVDRNEC--LEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTM-CMDVDECER 1940

  Fly  1793 VKCGPRAVCVTNNHQAQCQCPPGPFAGDPYDPFNGCQSVPCVYNHDCPPSQMCNRMTHTCFDVCD 1857
            ..|| ...|........|.|.||               ....:|:||.....|:....   .||
Human  1941 HPCG-NGTCKNTVGSYNCLCYPG---------------FELTHNNDCLDIDECSSFFG---QVC- 1985

  Fly  1858 EESCGDNAICLAEDHRAVCQCPPGFKGDP-------------LPEVACTKQGGCAAGTCHPSAIC 1909
                 .|..|..|.....|.|..|::..|             ||       |.|:.|||.
Human  1986 -----RNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALP-------GSCSPGTCQ----- 2033

  Fly  1910 EVTPEGPV-CKCPPLFVGDAKSGGCRPDGQC---PNGDADCPANTICAGGVCQNPCDNACGSNAE 1970
              ..||.. |.|||.:  :.||..|....:|   ||         ||..|.|.|
Human  2034 --NLEGSFRCICPPGY--EVKSENCIDINECDEDPN---------ICLFGSCTN----------- 2074

  Fly  1971 CKVINRKP---VCSCPLRFQPISDTAKDGCARTISKCLTDVDCGGALCYNGQCRI---------- 2022
                  .|   .|.||..| .:||..:.......|.|.|:.:       ||:|.:
Human  2075 ------TPGGFQCLCPPGF-VLSDNGRRCFDTRQSFCFTNFE-------NGKCSVPKAFNTTKAK 2125

  Fly  2023 -ACRNSQDCSDGESCLKNVCVVACLDHSQCASGLACVEGHCTIGCRSNKECKQDQSCIENKCLNP 2086
             .|........|:.|      ..|....:.|....|..||.|:  .|..:.::|    .|:||
Human  2126 CCCSKMPGEGWGDPC------ELCPKDDEVAFQDLCPYGHGTV--PSLHDTRED----VNECL-- 2176

  Fly  2087 CQSANSCGPNALCSIDQHHSQCSCPEGFEGNPTPEQGCVRVPAPCLASNQCPSGHMCIGNQCNLP 2151
             :|...|. |..|.......:|.||.|:..:.|                             .:.
Human  2177 -ESPGICS-NGQCINTDGSFRCECPMGYNLDYT-----------------------------GVR 2210

  Fly  2152 CTKTASCAVGERCYQQVCRKVCYTSNNCLAGEICNSDRTCQPGCDSDADCPPTELCLTGKCKCAT 2216
            |..|..|::|..|....|                                  |.:..:.:|.|..
Human  2211 CVDTDECSIGNPCGNGTC----------------------------------TNVIGSFECNCNE 2241

  Fly  2217 GF-IGTPFGCSDIDECTEQPCHASARCENLPGTYRCVCPEGTVGDGYSQPGCSQPRQCHKPDDCA 2280
            || .|....|.||:||.:.|...:.||.|..|:|.|.||     .||:..  ...:.|...|:||
Human  2242 GFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCP-----IGYALR--EDQKMCKDLDECA 2299

  Fly  2281 NNLACIHGKCTDPCLHTVCGINANCQSEGHEA-------LCSCPAGFLGDPNDTGVGCFKVECID 2338
            ..            ||       :|:|.|...       :|.||.|....|:..|
Human  2300 EG------------LH-------DCESRGMMCKNLIGTFMCICPPGMARRPDGEG---------- 2335

  Fly  2339 HVDCAGDRACDAETNRCIKPCDLTSCGKGNCQVRDHKATCACYEGYQLVNDVCEDINECLSQP-- 2401
                                                                |.|.|||.::|
Human  2336 ----------------------------------------------------CVDENECRTKPGI 2348

  Fly  2402 CHSTAFCNNLPGSYSCQCPEGLIGDPLQAGCRDPNECLSDAD-----CPASASCQNSRCRSPCER 2461
            |.: ..|.|:.|||.|:|.||.........|.|..:.|..|:     |..::|.:|...:|.|..
Human  2349 CEN-GRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCC 2412

  Fly  2462 QNACGLNANCQAQAHQAICTCPLNSRGDPTIECVHIECADNDDCSGEKACLDSKCIDPCS-LPNA 2525
            ....|....|:        .|||.........|.|          |.....|.:.||.|. :||.
Human  2413 DGGRGWGHQCE--------LCPLPGTAQYKKICPH----------GPGYTTDGRDIDECKVMPNL 2459

  Fly  2526 CGALARCSVQNHIGV--CSCEAGSTGD-AKLGCVQLQYCQQDGQ-CAQGSICSHGICSPLCSTNR 2586
            | ...:|.  |.:|.  |.|:.|.|.| :...|:.|..|.|..: |  ..||.:...|..||..|
Human  2460 C-TNGQCI--NTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPC--NYICKNTEGSYQCSCPR 2519

  Fly  2587 DCISEQLCLQGVCQG-TCKSNSSCPQFQFCSNNICTKEL----------------ECRSDSECGE 2634
            ..:.::       .| |||....|...|.....:|...|                .|..::|||.
Human  2520 GYVLQE-------DGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGS 2577

  Fly  2635 DETCLSDAYGRAKCESVCLGRAACGRNAECVARSHAPDCLCKEGFFGDAKSGCRKIECTSDDDCS 2699
            ..                   :.||....|.....:..|.|:.||..||..    :.|...|:|.
Human  2578 QP-------------------SLCGAKGICQNTPGSFSCECQRGFSLDATG----LNCEDVDECD 2619

  Fly  2700 NDKSCDNHMCKIAC---LIGQPCGENALCTTEH--HQQVCHCQPGFSGDPRVRCDVIDFCRDAPC 2759
            .     ||.|:..|   |.|..||    |...:  |.|...|           .|..:......|
Human  2620 G-----NHRCQHGCQNILGGYRCG----CPQGYIQHYQWNQC-----------VDENECSNPNAC 2664

  Fly  2760 GPGARCRNARGSYKCTCPPGLVGDPYNEGCRSSVECETNEDCPPHAACTKTNGVAKCRDVCAQLQ 2824
            | .|.|.|..|||||.||.|...|.::..|....||.:::: |.:..|:.|.|...|       .
Human  2665 G-SASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKN-PCNYGCSNTEGGYLC-------G 2720

  Fly  2825 CGPNAECVPKGHVAQCACRSGYD-GQPADRVAGCKPLPSPCQVTGDCPTNTYCSDSVCKPACVLD 2888
            |.|....|.:||   |....|:: ||                         |.|         ||
Human  2721 CPPGYYRVGQGH---CVSGMGFNKGQ-------------------------YLS---------LD 2748

  Fly  2889 TECGAFEVCQGGQCFNPCLQPQACGQNAECVMQNHLKQ 2926
            ||...          ...|.|:||   .||.:..:.|:
Human  2749 TEVDE----------ENALSPEAC---YECKINGYSKK 2773

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.