DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and Son

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_849211.3 Gene:Son / 20658 MGIID:98353 Length:2444 Species:Mus musculus


Alignment Length:2887 Identity:582/2887 - (20%)
Similarity:932/2887 - (32%) Gaps:865/2887 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  4409 LETTTNVPI-GSTGGQVTGQTTSSPSE-------------VRTTIR----VEESTLPSRSAD-RT 4454
            |...||.|| |:..|.......|.|:|             :.|.:|    ::|::..||... :|
Mouse    33 LNGETNPPIEGNQAGDTAASARSLPNEEIVQKIEEVLSGVLDTELRYKPDLKEASRKSRCVSVQT 97

  Fly  4455 TPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTR-PFEA---------------------STP 4497
            .|::  |.||..........:.:|..:..::....| |.|:                     |.|
Mouse    98 DPTD--EVPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKLKSHHDGNLESDSFLKFDSEP 160

  Fly  4498 SSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTLSESP 4562
            |:|:||..|.:..|...:...:      |.|....| .||:.:..:|.....:::|:.:.:|.| 
Mouse   161 SAAALEHPVRAFGLSEASETAL------VLEPPVVS-MEVQESHVLETLKPATKAAELSVVSTS- 217

  Fly  4563 ETPTTLPSDFTIRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVT----SETTTNVPIGS 4623
                      .|...|||                  |.|..||   ||:|    |.|...||:.:
Mouse   218 ----------VISEQSEQ------------------PMPGMLE---PSMTKILDSFTAAPVPMST 251

  Fly  4624 TGGQVTGQTTAPPSEFRTTIRVEESTLPSRSTDRTTPSESPETPTILPSDSTTRTYSDQTTESTR 4688
            ...:..........|::.::.....|:|. .|.:||..|.|....:.||::.| ..|:..||   
Mouse   252 AALKSPEPVVTMSVEYQKSVLKSLETMPP-ETSKTTLVELPIAKVVEPSETLT-IVSETPTE--- 311

  Fly  4689 DVPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLP 4753
                ..|    .|||::::....|     ||:|.      ::.||...:|||:            
Mouse   312 ----VHP----EPSPSTMDFPESS-----TTDVQ------RLPEQPVEAPSEI------------ 345

  Fly  4754 SRSADRTTPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEASTPSSASLETTVPSVTLE 4818
             ..:..|.|.||.|.|.|...:.     .|.|..|..::|       ..|:::.||...|.||  
Mouse   346 -ADSSMTRPQESLELPKTTAVEL-----QESTVASALELP-------GPPATSILELQGPPVT-- 395

  Fly  4819 TTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFITRPH 4883
                 |:....|         ||         .:.:|..|...:||  .||.|            
Mouse   396 -----PVPELPG---------PS---------ATPVPELSGPLSTP--VPELP------------ 423

  Fly  4884 SEKTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTT 4948
                               ..|:     |.||.:...:.|.||      |::::....|:     
Mouse   424 -------------------GPPA-----TVVPELPGPSVTPVP------QLSQELPGPPA----- 453

  Fly  4949 IRVEESTLPSRSTDRTTPSESPETP------TTLPS-----DFTTRPHSEQTTESTRDVPTTRPF 5002
                    ||...:  .|.|.||.|      :.:|:     :.|.:|......|.|....||..|
Mouse   454 --------PSMGLE--PPQEVPEPPVMAQELSGVPAVSAAIELTGQPAVTVAMELTEQPVTTTEF 508

  Fly  5003 EASTPSPASLETTV-----PSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRS 5062
            |    .|.:: |||     |.||..|      |..|..........|.:...|..:|.|..||.:
Mouse   509 E----QPVAM-TTVEHPGHPEVTTAT------GLLGQPEAAMVLELPGQPVATTALELSGQPSVT 562

  Fly  5063 ADRTTPSESPETPTTLPSDFITRTYSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTT 5127
            .       .||. :.|||                   .||..|.|..|.|:....:|.....|..
Mouse   563 G-------VPEL-SGLPS-------------------ATRALELSGQSVATGALELPGQLMATGA 600

  Fly  5128 NVPIGSTGG----------------QVTGQTTAP--PSEFRTTIRVEESTLPSRSTDRTTPSESP 5174
            ....|.:|.                ::.||..||  |.:...|:.:|.|                
Mouse   601 LEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVALEIS---------------- 649

  Fly  5175 ETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGSTGGQ 5239
                 :.|..||...|..|...:.:||:|...|:.......|.||:..   ||:..|.:.....|
Mouse   650 -----VQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVG---ETSVTVGVDPLMAQ 706

  Fly  5240 VTEQTTSSPSEVRTTIRVEESTLPSRS-ADRTTPSESPETPTLPSDF--TTRPHSEQTTESTRD- 5300
            .:....|:..|   |..:..:|:.|:. |..|..|:...:.|:.|..  ::...|:....||.| 
Mouse   707 ESHMLASNTME---THMLASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLASSTMDS 768

  Fly  5301 -VPATRPFEASTPSPASLETTVPSVTSEATTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLP 5364
             :.||...::...:.:|:::.:.:.:|..:..:...|...|:. .|:|..|::..|..::...|.
Mouse   769 QMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQML-ATSSMDSQMLATSSMDSQMLA 832

  Fly  5365 SRSTD----RTSPSESPETPTTLPSDFTTRPHSDQTTECTRDVPTTRPFEASTPSSASLETTVPS 5425
            :.|.|    .||..:|                         .:..|...::...:|.::::.:.:
Mouse   833 TSSMDSQMLATSSMDS-------------------------QMLATSSMDSQMLASGAMDSQMLA 872

  Fly  5426 VTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPE---------- 5480
            ........:..|:...|:...:|.           :.:.:.|:|.|....::.|.          
Mouse   873 SGTMDAQMLASGTMDAQMLASSTQ-----------DSAMMGSKSPDPYRLAQDPYRLAQDPYRLG 926

  Fly  5481 ---------------------------TPTLPSDFTTRPHSEQTTESTRDVPTTRPFE-ASTP-S 5516
                                       ||. |...:.||: .....|.|..|  ||:. |..| .
Mouse   927 HDPYRLGHDAYRLGQDPYRLGHDPYRLTPD-PYRVSPRPY-RIAPRSYRIAP--RPYRLAPRPLM 987

  Fly  5517 SASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEFRTTIRVEESTLPSRSADRTTPSESPE 5581
            .||..:.:.|...|                  .|..|.:..::...|.::.|..|:|:..|....
Mouse   988 LASRRSMMMSYAAE------------------RSMMSSYERSMMSYERSMMSPMAERSMMSAYER 1034

  Fly  5582 TPTLPSDF---TTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGG 5643
              ::.|.:   ...|.:|::..|..:......:|.|..||.:           ..:.:.:|:...
Mouse  1035 --SMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMA-----------DRSMMSMGADRS 1086

  Fly  5644 QVTGQTTAPPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTILPSDSTTRTYSDQTTESTRDVP 5708
            .::..:.|..| :.::....:.::.|..|||:..|        :.:||.|.:|:|..||:.. ||
Mouse  1087 MMSSYSAADRS-MMSSYSAADRSMMSSYTDRSMMS--------MAADSYTDSYTDSYTEAYM-VP 1141

  Fly  5709 TTRPFEAST--------------------PSPASLETTVPSVTLETT--TNVPIGSTGGQVTGQT 5751
            ...|.|..|                    |...:|.|...::|.:.|  |.|.:.      ||::
Mouse  1142 PLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALSTEQSALTADNTWSTEVTLS------TGES 1200

  Fly  5752 TATP------SEVRTTIGV---------EESTLPSRSTDRT-SPSESPETP-TTLPSDFTT---- 5795
            .:.|      ||:...:.|         |.|.|.|.:.... .|:..||:. |:.|.:...    
Mouse  1201 LSQPEPPVSQSEISEPMAVPANYSMSESETSMLASEAVMTVPEPAREPESSVTSAPVESAVVAEH 1265

  Fly  5796 -----RPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNV-PIGSTGGQVTEQ-- 5852
                 ||.:...:|:|..|         .|:..:.|.:|.|.||||..:: |.|....:||..  
Mouse  1266 EMVPERPMTYMVSETTMSV---------EPAVLTSEASVISETSETYDSMRPSGHAISEVTMSLL 1321

  Fly  5853 ----TTSSPSEVRTTIGLEESTLPSRSTDRTSPSESPETPTT-LPSDFITRPHSDQTTE------ 5906
                |.|.|:|  .::.|...|:|:.||..|  :|||....| :|...:..|......|      
Mouse  1322 EPAVTISQPAE--NSLELPSMTVPAPSTMTT--TESPVVAVTEIPPVAVPEPPIMAVPELPTMAV 1382

  Fly  5907 -STRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEVRTTIGVEE 5970
             .|..|....|..|: |.|.::.|  |.:.|.:.:..|:..:    .....|.|....|.:....
Mouse  1383 VKTPAVAVPEPLVAA-PEPPTMAT--PELCSLSVSEPPVAVS----ELPALADPEHAITAVSGVS 1440

  Fly  5971 STLPSRSTDRTSPSES----------PETPTTLPSDFITRPH---SEQTTESTRDVPTTRPFEAS 6022
            |..|  |.....|:.|          |..|...|:..::.|.   ||.|       ..|.|..|.
Mouse  1441 SLEP--SVPILEPAVSVLQPVMIVSEPSVPVQEPTVAVSEPAVIVSEHT-------QITSPEMAV 1496

  Fly  6023 TPSPASLKTTVPSVTSEATTNVPIG--STGQRIGTT-----PSESPETPTTLPSDFTTRPHSEKT 6080
            ..||..:.::|.|.......|:..|  :.|..:|..     |.|.|.....|.||.         
Mouse  1497 ESSPVIVDSSVMSSQIMKGMNLLGGDENLGPEVGMQETLLHPGEEPRDGGHLKSDL--------- 1552

  Fly  6081 TESTRDVPTTRPFETSTPSPASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVE 6145
                        :|......|.|......:..:...|....:|.|.|.|.:             |
Mouse  1553 ------------YENEYDRNADLTVNSHLIVKDAEHNTVCATTVGPVGEAS-------------E 1592

  Fly  6146 ESTLPSRSADRTTPSESPETPTLPSDFTT------RPHSEQTTESTRDVPTTRPFEASTPSPASL 6204
            |..||.        ||:.|...|.:....      |..|.|.......|.|::.||..|.|....
Mouse  1593 EKILPI--------SETKEITELATCAAVSEADIGRSLSSQLALELDTVGTSKGFEFVTASALIS 1649

  Fly  6205 ETTVP---SVTSETT------TNVPIGSTGGQVTGQTTAP------PSEVRTTIGVEESTLPSRS 6254
            |:...   |||::.|      :..|.|.:...:.|...|.      ||.......||:| ||.:.
Mouse  1650 ESKYDVEVSVTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSTNFVCKDVEDS-LPIKE 1713

  Fly  6255 TDRT-----SPSESPETPTTLPSDFITRPHSEQTTESTRDVPTTRPFEASTPSPASLKTTVPSVT 6314
            :.:.     ||.||.| .|.:|     .|:.|...||..........||....|...|      .
Mouse  1714 SAQAVAVALSPKESSE-DTEVP-----LPNKEIVPESGYSASIDEINEADLVRPLLPK------D 1766

  Fly  6315 SEATTNVPIGSTG---GQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDF 6376
            .|..|::..|..|   ....|:..|:.|.|..:|                |..:.|:.:....|:
Mouse  1767 MERLTSLRAGIEGPLLASEVERDKSAASPVVISI----------------PERASESSSEEKDDY 1815

  Fly  6377 TTRPHSEKTTESTRDVPTTRPFETSTPSPASLETTVPSVTLETTTSVPMGSTGGQVTGQTTAPPS 6441
            ......:.|.|.::........|......:||.:.                       ...:..|
Mouse  1816 EIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSR-----------------------SKRSKSS 1857

  Fly  6442 EVRTTIRVEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEA-STP 6505
            |.::..|..||.  ||:..|:|.|:|..:.|.      :|..|.:...|:|....:|...: |..
Mouse  1858 EHKSRKRTSESR--SRARKRSSKSKSHRSQTR------SRSRSRRRRRSSRSRSKSRGRRSVSKE 1914

  Fly  6506 SSASSGNNCSISYFRNHYKCSNRFNRSADRT---TPSESPETPTLPSDFTTRPHSEQTTESTRDV 6567
            ....|..:.|.|..|...:.|:|.||.|.|.   |||.           .:|.|:......:|.|
Mouse  1915 KRKRSPKHRSKSRERKRKRSSSRDNRKAARARSRTPSR-----------RSRSHTPSRRRRSRSV 1968

  Fly  6568 PTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEVRTTIRVEESTLPSR 6632
            ...|.|..|           ||..|.|                   |....||..|  .|..|||
Mouse  1969 GRRRSFSIS-----------PSRRSRT-------------------PSRRSRTPSR--RSRTPSR 2001

  Fly  6633 STDRTTPSESPETPTILPSDFTTRPHSDQTTESTRDVPTTRPFEASTPRPVTLETAVPSVTLETT 6697
            .:  .|||....||:              ....:|.....|.|..|   ||.|..:         
Mouse  2002 RS--RTPSRRSRTPS--------------RRRRSRSAVRRRSFSIS---PVRLRRS--------- 2038

  Fly  6698 TNVPIGSTGGQVTGQTTATPSEVRTTIRVEESTLP-----SRSTDRTTPSESPETPTTLPSDFTT 6757
                                   ||.:|...|..|     |||::|   ..||:..|.|      
Mouse  2039 -----------------------RTPLRRRFSRSPIRRKRSRSSER---GRSPKRLTDL------ 2071

  Fly  6758 RPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTEQTTSSPSEV 6822
              ...|..|..:........:|..|.|.:|:...|....|....    .:||...|:.|....::
Mouse  2072 --DKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAK----KSGGATIEELTEKCKQI 2130

  Fly  6823 RTTIGLEESTLPSRSTDRTSPSESPETPTTLPSDFITRPH-SDQTTESTRDVP-TTRPFEASTPS 6885
                                 ::|.|....:    :.:|| ||:..|   :.| ...||:.|.|.
Mouse  2131 ---------------------AQSKEDDDVI----VNKPHVSDEEEE---EPPFYHHPFKLSEPK 2167

  Fly  6886 P-------ASLETTVPSVTSETTTNVPIGSTGGQVTEQTTSSPSEVRTTIGLEESTLPSRSTDRT 6943
            |       |:.:.|.|......|...|: |:|.|  .:...:.|.....:.:|::...|:..|..
Mouse  2168 PIFFNLNIAAAKPTPPKSQVTLTKEFPV-SSGSQ--HRKKEADSVYGEWVPVEKNGEESKDDDNV 2229

  Fly  6944 SPSESPETPTTLPSDFITRPHSD-QTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVP 7007
            ..|..|..|..:.:....|..:. :.:|:..|:      ||.:..:.:.|.......|.:.....
Mouse  2230 FSSSLPSEPVDISTAMSERALAQKRLSENAFDL------EAMSMLNRAQERIDAWAQLNSIPGQF 2288

  Fly  7008 IGSTGGQVTEQTTSSPSEVRTTIRVEE 7034
            .||||.||..|...:.:..:..|:.::
Mouse  2289 TGSTGVQVLTQEQLANTGAQAWIKKDQ 2315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395 67/313 (21%)
DUF4758 4275..4448 CDD:292572 13/56 (23%)
DUF4758 4377..4574 CDD:292572 41/205 (20%)
DUF4758 4581..4754 CDD:292572 38/176 (22%)
DUF4758 4683..4847 CDD:292572 36/163 (22%)
DUF4758 4785..4964 CDD:292572 31/178 (17%)
DUF4696 4841..5385 CDD:292395 118/586 (20%)
DUF4758 4887..5098 CDD:292572 46/226 (20%)
DUF4758 5193..5371 CDD:292572 39/186 (21%)
DUF4758 5294..5487 CDD:292572 31/235 (13%)
DUF4758 5445..5650 CDD:292572 37/246 (15%)
DUF4758 5700..5877 CDD:292572 54/231 (23%)
DUF4696 5756..6396 CDD:292395 158/723 (22%)
DUF4758 5802..5979 CDD:292572 48/191 (25%)
DUF4758 5964..6171 CDD:292572 46/226 (20%)
DUF4758 6181..6360 CDD:292572 46/201 (23%)
DUF4696 6339..6999 CDD:292395 132/678 (19%)
DUF4758 6662..6839 CDD:292572 32/181 (18%)
DUF4758 6764..6941 CDD:292572 35/185 (19%)
DUF4758 6866..7045 CDD:292572 37/178 (21%)
DUF4758 6968..7179 CDD:292572 14/67 (21%)
DUF4696 7024..7569 CDD:292395 1/11 (9%)
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
SonNP_849211.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 23..58 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 79..155 12/77 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 301..358 21/92 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 391..468 29/160 (18%)
13 X 10 AA tandem repeats of L-A-[ST]-[NSG]-[TS]-MDSQM 721..850 27/154 (18%)
11 X 7 AA tandem repeats of [DR]-P-Y-R-[LI][AG][QHP] 907..983 12/79 (15%)
14 X 6 AA repeats of [ED]-R-S-M-M-S 1001..1120 23/150 (15%)
Forkhead_N 1011..1137 CDD:254796 27/147 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1141..1213 15/77 (19%)
3 X 11 AA tandem repats of P-P-L-P-P-E-E-P-P-[TME]-[MTG] 1141..1173 5/31 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1802..2072 82/405 (20%)
7 X 7 AA repeats of P-S-R-R-S-R-[TS] 1950..2019 26/127 (20%)
2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-S 1959..2030 25/118 (21%)
3 X tandem repeats of [ST]-P-[VLI]-R-[RL]-[RK]-[RF]-S-R 2031..2057 9/60 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2192..2238 10/48 (21%)
G-patch 2323..2366 CDD:279867
DSRM 2389..>2426 CDD:238007
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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