DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and Siglec1

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:XP_036015809.1 Gene:Siglec1 / 20612 MGIID:99668 Length:1719 Species:Mus musculus


Alignment Length:1789 Identity:351/1789 - (19%)
Similarity:552/1789 - (30%) Gaps:563/1789 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  4161 PSDSTTRTYSDQTTESTR--DVPTTRPFEASTPSPASLETTVPSVTLETTTNDPIGSTGGQVTEQ 4223
            |.||.|..:..:.::|.|  ||..|.....:.|||       |::|:                  
Mouse   113 PEDSGTYNFRFEISDSNRWLDVKGTTVTVTTDPSP-------PTITI------------------ 152

  Fly  4224 TTSSPSEVRTTIGLEESTLPSRSTDRTTPSESPETPTTLPSDFITRPHSDQTTESTRDVPT---T 4285
                |.|:|.  |:|      |:.:.:||             ::.......:.:.....||   |
Mouse   153 ----PEELRE--GME------RNFNCSTP-------------YLCLQEKQVSLQWRGQDPTHSVT 192

  Fly  4286 RPFEASTPSSASLETTVPSV--------TLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEES 4342
            ..|::..|:....:||:...        ||....::...|:..:|..|...:|..|        .
Mouse   193 SSFQSLEPTGVYHQTTLHMALSWQDHGRTLLCQFSLGAHSSRKEVYLQVPHAPKGV--------E 249

  Fly  4343 TLPSRSADRTTPSESPETPTTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSV 4407
            .|.|.|.....|.:    |.||    |.|.:|                  |.|:.::::.....|
Mouse   250 ILLSSSGRNILPGD----PVTL----TCRVNS------------------SYPAVSAVQWARDGV 288

  Fly  4408 TLETTTNV---------PIGSTGGQVT---GQTTSSP-------SEVR-----TTIRVEESTLPS 4448
            .|..|.:|         ..|:...|.|   |...|||       :||:     ..:..|..||..
Mouse   289 NLGVTGHVLRLFSAAWNDSGAYTCQATNDMGSLVSSPLSLHVFMAEVKMNPAGPVLENETVTLLC 353

  Fly  4449 RSADRTTPSESPET----------------PTTLPSDFITRPHSEKTTESTRDVPTTRPFEASTP 4497
                 :||.|:|:.                .:||....:||   ..|.....:|...:..|.|:|
Mouse   354 -----STPKEAPQELRYSWYKNHILLEDAHASTLHLPAVTR---ADTGFYFCEVQNAQGSERSSP 410

  Fly  4498 SSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTLSESP 4562
              .|:....|.:|.:.||.  :.:..|.|.....|..||...|:.:....|       |..|.|.
Mouse   411 --LSVVVRYPPLTPDLTTF--LETQAGLVGILHCSVVSEPLATVVLSHGGL-------TLASNSG 464

  Fly  4563 ETPTTLPSDFTIRPHSEQTTESTR-DVPTTRPFEASTPSPASLETTVPSVTS-ETTTNVP---IG 4622
            |      :||..|........|.| ::...:|.::...:..::.:...|.:| :...||.   |.
Mouse   465 E------NDFNPRFRISSAPNSLRLEIRDLQPADSGEYTCLAVNSLGNSTSSLDFYANVARLLIN 523

  Fly  4623 STGGQVTGQTTAPPSEFRTTIRVEESTLPSRSTDRTTPS-------------ESPETPTILPSDS 4674
            .:...|.||..               ||..||.....|.             |...:..:||:.|
Mouse   524 PSAEVVEGQAV---------------TLSCRSGLSPAPDTRFSWYLNGALLLEGSSSSLLLPAAS 573

  Fly  4675 TT-------RTYSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGSTGGQVTE 4732
            :|       ||.:...| |...:||.    .:...|....|....:.|: |:.|..|..|..:..
Mouse   574 STDAGSYYCRTQAGPNT-SGPSLPTV----LTVFYPPRKPTFTARLDLD-TSGVGDGRRGILLCH 632

  Fly  4733 QTTSSPSEVRTTIR--VEESTLPSRSADRTTPSESPETPTTLPSDFITRPHSE-------KTTES 4788
            ..:..|:::|...:  |..::||||....:..::...|..:|..: |.:|..|       :.:.:
Mouse   633 VDSDPPAQLRLLHKGHVVATSLPSRCGSCSQRTKVSRTSNSLHVE-IQKPVLEDEGVYLCEASNT 696

  Fly  4789 TRDVPTTRPFEAS------TPSSASLETTVPSVTLETTTNVPIGST------GGQVTEQTTSSPS 4841
            ..:......|.|.      |||:...|.|..::|......|.:...      .|.:..|.:....
Mouse   697 LGNSSAAASFNAKATVLVITPSNTLREGTEANLTCNVNQEVAVSPANFSWFRNGVLWTQGSLETV 761

  Fly  4842 EVRTTIRVEESTLPSR-----SADRTTP-----SESPETPTTLPSDFITRPHSEKTTESTRDVPT 4896
            .::...|.:.:....|     .|..:.|     ..:|:.|.......:.:.|......:....|.
Mouse   762 RLQPVARTDAAVYACRLLTEDGAQLSAPVVLSVLYAPDPPKLSALLDVGQGHMAVFICTVDSYPL 826

  Fly  4897 TR------------PFEASTPSSASLE--TTVPSVTLET--------------TTNVPIGSTGGQ 4933
            ..            ..|...||...::  .|..|:.||.              .||: :||....
Mouse   827 AHLSLFRGDHLLATNLEPQRPSHGRIQAKATANSLQLEVRELGLVDSGNYHCEATNI-LGSANSS 890

  Fly  4934 VTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTT-------RPHSEQTTE 4991
            :..|...:..:|..:..:.|......|.         :.||.: |:.|:       ||..|.|:.
Mouse   891 LFFQVRGAWVQVSPSPELREGQAVVLSC---------QVPTGV-SEGTSYSWYQDGRPLQESTSS 945

  Fly  4992 STR----------------DVPTTRPFEASTPSPASLET--TVPSVTLETTTNVPIGSTGGQVTE 5038
            :.|                ..|.|.  .||..:|.||..  |...|||....:......|..|..
Mouse   946 TLRIAAISLRQAGAYHCQAQAPDTA--IASLAAPVSLHVSYTPRHVTLSALLSTDPERLGHLVCS 1008

  Fly  5039 QTTSSPSEVRT--TIRVEESTLPSRSADRTTPSESPETPTTLPSDFITR----------TYSDQT 5091
            ..:..|::::.  ..|:..|||  :.||....|......|.||::...:          ||:.:.
Mouse  1009 VQSDPPAQLQLFHRNRLVASTL--QGADELAGSNPRLHVTVLPNELRLQIHFPELEDDGTYTCEA 1071

  Fly  5092 TESTRDVPTTRPFEASTPSPASLETTV-PSVTSETTTNVP----IGST-----------GGQVTG 5140
            :.:.........|:|.     ::..|| |:.|.:....|.    :.||           |||   
Mouse  1072 SNTLGQASAAADFDAQ-----AVRVTVWPNATVQEGQQVNLTCLVWSTHQDSLSYTWYKGGQ--- 1128

  Fly  5141 QTTAPPSEFRTTIRVEESTLPS-RSTDRTT-------PSESPETPTTLPSDFTTRPHSDQTTEST 5197
                      ..:.....|||| :..|.|:       |..:|.         .:||.:.....:.
Mouse  1129 ----------QLLGARSITLPSVKVLDATSYRCGVGLPGHAPH---------LSRPVTLDVLHAP 1174

  Fly  5198 RDVPTTRPFEASTPSPASLETTVPS-----VTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRV 5257
            |::..|...|......|.:..||.|     :||         |.|.|:.  .:|:.:.|..|:|:
Mouse  1175 RNLRLTYLLETQGRQLALVLCTVDSRPPAQLTL---------SHGDQLV--ASSTEASVPNTLRL 1228

  Fly  5258 E-ESTLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTR-------DVPATRPFEASTPSP 5314
            | :...||.....:..:.||......|       .|...|..|       .||...|...:...|
Mouse  1229 ELQDPRPSNEGLYSCSAHSPLGKANTS-------LELLLEGVRVKMNPSGSVPEGEPVTVTCEDP 1286

  Fly  5315 ASL---------------ETTVPSVTSEATTNVPIGSTGGQV--TEQTTSS-PSEVRTTIRVEES 5361
            |:|               |....|:....||....|:...||  |:.|.|| |:.::......::
Mouse  1287 AALSSALYAWFHNGHWLQEGPASSLQFLVTTRAHAGAYFCQVHDTQGTRSSRPASLQILYAPRDA 1351

  Fly  5362 TLPSRSTDRTS---------PSESPETPTTLPSDFTTRPHSDQTTECTRDVPTTRPFEASTPSSA 5417
            .|.|....||.         .||.|..        ....|:.:....:.:          ..|||
Mouse  1352 VLSSFRDSRTRLMVVIQCTVDSEPPAE--------MVLSHNGKVLAASHE----------RHSSA 1398

  Fly  5418 S-----------LETTVPSVTL---ETTTNVPIGSTGGQVTEQTTSSPSEVRTT----IRVEEST 5464
            |           |...|..|||   .|.......:.|...|.|...:.:::|.|    :.|.|.|
Mouse  1399 SGIGHIQVARNALRLQVQDVTLGDGNTYVCTAQNTLGSISTTQRLLTETDIRVTAEPGLDVPEGT 1463

  Fly  5465 -------LPSRSADRTTPSESPETPTLPSDFT-----TRPHSEQTTESTRDVPTTRPFEASTPSS 5517
                   ||..|.           ||..|.||     .|.||       ..|||. .|.....:.
Mouse  1464 ALNLSCLLPGGSG-----------PTGNSSFTWFWNRHRLHS-------APVPTL-SFTPVVRAQ 1509

  Fly  5518 ASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEFRTTIRVEESTLPSRSADRTTPSESPET 5582
            |.|        .....::|.|:        |||:|...|...                   .|:|
Mouse  1510 AGL--------YHCRADLPTGA--------TTSAPVMLRVLY-------------------PPKT 1539

  Fly  5583 PTL---------------------PSDFTTRPHSEQTTESTR--DVPTTRPFEASTPSPASLETT 5624
            |||                     |....|.....|...|.:  |.| |:|....|..|.:|...
Mouse  1540 PTLIVFVEPQGGHQGILDCRVDSEPLAILTLHRGSQLVASNQLHDAP-TKPHIRVTAPPNALRVD 1603

  Fly  5625 V----PSVTSE---TTTNVPIGSTGGQVTGQTTA 5651
            :    ||...|   |.:|. :||........|.|
Mouse  1604 IEELGPSNQGEYVCTASNT-LGSASASAYFGTRA 1636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572 22/122 (18%)
DUF4696 4127..4678 CDD:292395 117/594 (20%)
DUF4758 4275..4448 CDD:292572 42/207 (20%)
DUF4758 4377..4574 CDD:292572 49/236 (21%)
DUF4758 4581..4754 CDD:292572 38/199 (19%)
DUF4758 4683..4847 CDD:292572 34/184 (18%)
DUF4758 4785..4964 CDD:292572 34/228 (15%)
DUF4696 4841..5385 CDD:292395 130/682 (19%)
DUF4758 4887..5098 CDD:292572 51/275 (19%)
DUF4758 5193..5371 CDD:292572 45/208 (22%)
DUF4758 5294..5487 CDD:292572 51/251 (20%)
DUF4758 5445..5650 CDD:292572 53/250 (21%)
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
Siglec1XP_036015809.1 IgV_CD33 27..134 CDD:409377 6/20 (30%)
Ig strand B 43..47 CDD:409377
Ig strand C 62..66 CDD:409377
Ig strand E 104..108 CDD:409377
Ig strand F 118..123 CDD:409377 1/4 (25%)
C2-set_2 148..235 CDD:400489 20/129 (16%)
Ig strand A 148..153 CDD:409353 2/26 (8%)
Ig strand B 161..169 CDD:409353 2/13 (15%)
Ig strand C 178..184 CDD:409353 0/5 (0%)
Ig strand D 193..199 CDD:409353 1/5 (20%)
Ig strand E 203..212 CDD:409353 2/8 (25%)
Ig strand G 231..239 CDD:409353 2/7 (29%)
Ig strand A 245..253 CDD:409353 3/15 (20%)
Ig strand A' 257..261 CDD:409353 0/3 (0%)
IGc2 261..319 CDD:197706 16/83 (19%)
Ig strand B 262..272 CDD:409353 5/17 (29%)
Ig strand C 279..285 CDD:409353 0/5 (0%)
Ig strand C' 287..290 CDD:409353 1/2 (50%)
Ig strand E 296..301 CDD:409353 1/4 (25%)
Ig strand F 308..316 CDD:409353 2/7 (29%)
Ig strand G 319..330 CDD:409353 4/10 (40%)
Ig 334..417 CDD:416386 19/92 (21%)
Ig strand A' 342..345 CDD:409353 0/2 (0%)
Ig strand B 346..356 CDD:409353 3/14 (21%)
Ig strand C 363..369 CDD:409353 0/5 (0%)
Ig strand C' 371..374 CDD:409353 0/2 (0%)
Ig strand E 380..386 CDD:409353 2/5 (40%)
Ig strand F 393..401 CDD:409353 1/7 (14%)
Ig strand G 404..417 CDD:409353 4/14 (29%)
Ig strand A' 412..415 CDD:409353 1/2 (50%)
Ig 428..511 CDD:416386 18/95 (19%)
Ig strand B 436..443 CDD:409353 1/6 (17%)
Ig strand C 449..454 CDD:409353 1/4 (25%)
Ig strand C' 456..458 CDD:409353 1/8 (13%)
Ig strand D 471..477 CDD:409353 1/5 (20%)
Ig strand E 480..486 CDD:409353 2/5 (40%)
Ig strand F 494..502 CDD:409353 0/7 (0%)
Ig_3 523..583 CDD:404760 13/74 (18%)
IG 624..702 CDD:214652 14/78 (18%)
Ig_3 712..777 CDD:404760 10/64 (16%)
Ig strand A' 720..723 CDD:409353 0/2 (0%)
Ig strand B 724..734 CDD:409353 2/9 (22%)
Ig strand C 742..748 CDD:409353 0/5 (0%)
Ig strand C' 750..753 CDD:409353 1/2 (50%)
Ig strand E 759..765 CDD:409353 0/5 (0%)
Ig strand F 772..780 CDD:409353 1/7 (14%)
Ig strand G 783..796 CDD:409353 2/12 (17%)
Ig 815..895 CDD:416386 12/80 (15%)
Ig strand B 815..819 CDD:409353 0/3 (0%)
Ig strand C 828..832 CDD:409353 0/3 (0%)
Ig strand E 861..865 CDD:409353 1/3 (33%)
Ig strand F 875..880 CDD:409353 0/4 (0%)
Ig 900..975 CDD:416386 16/86 (19%)
Ig strand A' 907..910 CDD:409353 0/2 (0%)
Ig strand B 911..921 CDD:409353 1/18 (6%)
Ig strand C 928..934 CDD:409353 1/5 (20%)
Ig strand C' 936..939 CDD:409353 1/2 (50%)
Ig strand E 945..951 CDD:409353 1/5 (20%)
Ig strand F 958..968 CDD:409353 0/9 (0%)
Ig strand G 971..984 CDD:409353 5/12 (42%)
IG_like 1005..1093 CDD:214653 16/94 (17%)
Ig strand C 1026..1031 CDD:409353 3/6 (50%)
Ig strand C' 1033..1035 CDD:409353 1/1 (100%)
Ig strand D 1042..1048 CDD:409353 1/5 (20%)
Ig strand E 1051..1057 CDD:409353 0/5 (0%)
Ig strand F 1065..1073 CDD:409353 2/7 (29%)
Ig_2 1095..1167 CDD:404734 18/93 (19%)
Ig strand A' 1095..1100 CDD:409353 2/4 (50%)
Ig strand B 1105..1114 CDD:409353 1/8 (13%)
Ig strand C 1121..1126 CDD:409353 0/4 (0%)
Ig strand C' 1128..1131 CDD:409353 1/15 (7%)
Ig strand E 1133..1138 CDD:409353 0/4 (0%)
Ig strand F 1148..1156 CDD:409353 0/7 (0%)
Ig strand G 1160..1170 CDD:409353 3/18 (17%)
IG_like 1195..1258 CDD:214653 18/80 (23%)
Ig strand C 1204..1208 CDD:409353 2/12 (17%)
Ig strand E 1226..1230 CDD:409353 1/3 (33%)
Ig strand F 1240..1245 CDD:409353 0/4 (0%)
Ig 1265..1344 CDD:416386 18/78 (23%)
Ig strand A' 1271..1274 CDD:409353 0/2 (0%)
Ig strand B 1278..1284 CDD:409353 1/5 (20%)
Ig strand C 1294..1299 CDD:409353 0/4 (0%)
Ig strand C' 1301..1303 CDD:409353 0/1 (0%)
Ig strand E 1309..1314 CDD:409353 1/4 (25%)
Ig strand F 1322..1327 CDD:409353 1/4 (25%)
Ig strand G 1338..1344 CDD:409353 1/5 (20%)
Ig <1365..1440 CDD:416386 15/92 (16%)
Ig strand B 1365..1372 CDD:409353 0/6 (0%)
Ig strand C 1378..1383 CDD:409353 0/12 (0%)
Ig strand C' 1386..1388 CDD:409353 0/1 (0%)
Ig strand D 1394..1407 CDD:409353 4/12 (33%)
Ig strand E 1409..1415 CDD:409353 1/5 (20%)
Ig strand F 1424..1432 CDD:409353 1/7 (14%)
Ig_3 1450..1517 CDD:404760 22/93 (24%)
Ig strand B 1555..1561 CDD:409353 0/5 (0%)
Ig <1556..1630 CDD:416386 18/75 (24%)
Ig strand C 1566..1571 CDD:409353 1/4 (25%)
Ig strand C' 1573..1575 CDD:409353 0/1 (0%)
Ig strand D 1592..1596 CDD:409353 1/3 (33%)
Ig strand E 1599..1603 CDD:409353 1/3 (33%)
Ig strand F 1613..1621 CDD:409353 2/7 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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