DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and ADGRE1

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_011526096.1	Gene:	ADGRE1 / 2015	HGNCID:	3336	Length:	978	Species:	Homo sapiens

Alignment Length:	603	Identity:	169/603 - (28%)
Similarity:	230/603 - (38%)	Gaps:	210/603 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 GACLNGVCHCNDGY---------GGCNCVDKDENECKQRPCDVFAHCTNTLGSFTCTCFPGY-RG 161
            |.|   |.|..:|:         .|.||.|       ...|..:|.||||:.|:.|.|..|: ..
Human    11 GCC---VMHSWEGHIRPTRKPNTKGNNCRD-------STLCPAYATCTNTVDSYYCACKQGFLSS 65

  Fly   162 NGFHCEDIDECQDPAIAARCVENAECCNLPAHFLCKCKDGYEGDGEVLCTDVDEC-RNPENCGPN 225
            ||                   :|        ||         .|..|.|.|:||| ::|:.||||
Human    66 NG-------------------QN--------HF---------KDPGVRCKDIDECSQSPQPCGPN 94

  Fly   226 ALCTNTPGNYTCSCPDGY---VGNN--PYREG---CQDVDECSYPNVCGPGAICTNLEGSYRCDC 282
            :.|.|..|.|.|||.||:   .||:  |.:.|   |.|::||...:||...:.|.|..|||.|.|
Human    95 SSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSSVCPEHSDCVNSMGSYSCSC 159

  Fly   283 PPGYDGDGRSESGCVDQDECART--PCGRNADCLNTDGSFRCLCPDGYS---------GDPMN-G 335
            ..|:..   ..|.|.|.|||:::  |||.|:.|.|..|.::|.|.||:|         |.|.| .
Human   160 QVGFIS---RNSTCEDIDECSQSPQPCGPNSSCKNMSGRYKCSCLDGFSSPTGNDWIPGKPGNFS 221

  Fly   336 CEDVDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQLGYGPGATDIAP 400
            |.|:.|..|::.|...::|||..||:.|.|..||:
Human   222 CTDISESLTSSVCPEHSDCVNSMGSYNCSCQVGFI------------------------------ 256

  Fly   401 YQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQ-GQGYL-------HCEN 457
             .|.|.:.    |:|||..|   ..|..:|.|.|..|:|.|.|..||: ..|:|       .||:
Human   257 -SRNSISS----DVDECADP---RACPEHATCNNTVGNYSCFCNPGFESSSGHLSFQGLKASCED 313

  Fly   458 INECQDNPCGENAICTDTVGSFVCTCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCENTVPGYN 522
            |:||.: .|..|:.||:|.||:.|||.|.:.  |..|.::
Human   314 IDECTE-MCPINSTCTNTPGSYFCTCHPGFA--PSNGQLN------------------------- 350

  Fly   523 CKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTNNAECIENQCFCLDGFEPIGSSCVDIDECRTH 587
                                                            |...|..|.||||||..
Human   351 ------------------------------------------------FTDQGVECRDIDECRQD 367

  Fly   588 AEVCGPHAQCLNTPGSYGCECEAGYVGSPPRMACKQPCEDVRCGAHAY-CKPD---QNEAYCVCE 648
            ...|||::.|.|..|||.|.|.||:..:|..   .|...:..|....: ||.|   .|:....|:
Human   368 PSTCGPNSICTNALGSYSCGCIAGFHPNPEG---SQKDGNFSCQRVLFKCKEDVIPDNKQIQQCQ 429

  Fly   649 DGWTYNPSDVAAGCVDID 666
            :|....|:.|:. |..|:
Human   430 EGTAVKPAYVSF-CAQIN 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699	12/29 (41%)
		EGF_CA	212..247	CDD:238011	19/38 (50%)
		EGF_CA	255..>286	CDD:214542	12/30 (40%)
		EGF_CA	298..331	CDD:238011	16/43 (37%)
		EGF_CA	338..373	CDD:238011	13/34 (38%)
		EGF_CA	413..456	CDD:238011	17/50 (34%)
		EGF_CA	457..490	CDD:238011	14/32 (44%)
		EGF_CA	497..>529	CDD:214542	0/31 (0%)
		EGF_CA	580..>612	CDD:214542	17/31 (55%)
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
ADGRE1	XP_011526096.1	EGF_CA	33..62	CDD:238011	12/35 (34%)
		EGF_CA	80..114	CDD:214542	18/33 (55%)
		EGF_CA	132..171	CDD:214542	14/41 (34%)
		EGF_CA	172..206	CDD:214542	15/33 (45%)
		EGF_CA	224..260	CDD:214542	14/66 (21%)
		EGF_CA	264..297	CDD:214542	15/35 (43%)
		EGF_CA	313..>342	CDD:214542	14/29 (48%)
		EGF_CA	360..400	CDD:284955	19/42 (45%)
		GPS	638..687	CDD:197639
		7tm_2	691..932	CDD:278432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910