DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and T19H12.6

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001360571.1	Gene:	T19H12.6 / 188617	WormBaseID:	WBGene00020590	Length:	592	Species:	Caenorhabditis elegans

Alignment Length:	623	Identity:	136/623 - (21%)
Similarity:	216/623 - (34%)	Gaps:	136/623 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  4659 TPSESPETPTILPSDSTTRTYS--DQTTESTRDVPTT--RPFEASTPSPASLE---------TTV 4710
            |.|||..|    .|:.:||||.  :..|.|....|.|  |.|:.||.||..::         ..|
Worm    61 TRSESSST----TSEYSTRTYQNFELQTISPSSSPLTFRRRFKTSTESPEGVDFNFSKDLDPVVV 121

  Fly  4711 PSVTLE--TTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLP 4773
            |.|..|  |||:         .|:...|:..|...::.|.|:....|:|..|:.:|.    :.:.
Worm   122 PVVPAEIITTTS---------TTKSHQSTILESVNSVEVFENDENLRAAVFTSSAEC----SAIG 173

  Fly  4774 SDFITRPHSEKTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTS 4838
            ...:.|..:              ..||:..:|..|...:|:.          .|.||.:. .|..
Worm   174 KSILVRGGN--------------AVEAAIAASFCLMGAMPNK----------ASLGGGLM-MTVK 213

  Fly  4839 SPSEVRTTIRVEESTLPSRSADRTTPSESPE----------TPTTLPSDF--ITRPHSEKTTEST 4891
            :.:...||| :...|.| .:||.....::||          ||.||...:  ..:..|.:.....
Worm   214 TKNGNATTI-IARETAP-MNADIDELKKNPELTHVGPKASGTPGTLNGLYRAFQKFSSNRVQWKH 276

  Fly  4892 RDVPTTRPFEASTPSSASLE--TTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEES 4954
            ..:||.:........|..|:  ::.|::......||       |..:...:|.|.:.|.|...||
Worm   277 LVLPTIQQCNKGFKLSEDLKKRSSAPALAQFFKANV-------QKDKILCTSLSTLLTDIADYES 334

  Fly  4955 TLPSRSTDRTTPSESPE-----TPTTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLET 5014
            .|.:.....|....:.|     |.:.| .|:.:...|...:|...|.....|     .||:|.
Worm   335 PLDAFYHGETAQKLAKELGGYMTASDL-EDYESDMSSAICSEIDVDTKVCGP-----GSPSSF-- 391

  Fly  5015 TVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLP 5079
            .|.:.|...|.|:              |:.::|...:| ....|.|:.||          |..:.
Worm   392 AVLANTYLATKNM--------------SNLAKVNDVLR-SSMGLISKIAD----------PMFVK 431

  Fly  5080 SDFITRTYSDQTTE-STRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTT 5143
            |   ::.|:::..: |.|.....:....:.....|.|.   .|..|....|.:..:.|...|...
Worm   432 S---SKKYTEELAKTSKRSSSEAKNLAVNFKEDGSTEV---FVIDENNMTVSVLLSLGDDFGSLI 490

  Fly  5144 APPSEF--RTTIR---VEESTLPSRSTDRTTPSE--SPETPTTLPSDFTTRPHSD--QTTESTRD 5199
            ...|.|  ...:|   |:...:|........|:.  ||.......|.|.....||  ......||
Worm   491 YSSSGFFWNNKLRYFDVKNENVPLSLQPGKVPTSLLSPIVVVKNNSVFAVSGGSDLLGLVHLLRD 555

  Fly  5200 VPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGSTG 5237
            : |.|.::||..:| ||......:||::.:|.....||
Worm   556 I-THRNYDASKVAP-SLFVQNSGITLKSPSNNKYSITG 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395	7/18 (39%)
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572	32/109 (29%)
		DUF4758	4683..4847	CDD:292572	37/176 (21%)
		DUF4758	4785..4964	CDD:292572	38/192 (20%)
		DUF4696	4841..5385	CDD:292395	90/426 (21%)
		DUF4758	4887..5098	CDD:292572	43/218 (20%)
		DUF4758	5193..5371	CDD:292572	14/45 (31%)
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
T19H12.6	NP_001360571.1	G_glu_transpept	175..544	CDD:388535	84/441 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910