DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and comt-1

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_508495.2	Gene:	comt-1 / 186152	WormBaseID:	WBGene00018741	Length:	634	Species:	Caenorhabditis elegans

Alignment Length:	606	Identity:	142/606 - (23%)
Similarity:	211/606 - (34%)	Gaps:	196/606 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  5981 TSPSESPETPTTLPSDFITRPHSEQTTESTRDVPTTRPFEASTPSPASLKT--TVPSVTSEATTN 6043
            |:.:..|:||...      ||         :.:|..:|...|.|:|..:.|  |.|..|...||:
Worm    93 TTSTPLPKTPKRF------RP---------KIIPVDKPETTSKPTPRPMPTVFTFPYTTPHFTTS 142

  Fly  6044 VPIGSTGQRIGTTPSESPETPTTLPSDFTTRPHSEKTTESTRDVPTTRP----FETSTPSPASLE 6104
            .|:              ||..:|    :..||....||       ||.|    |         ::
Worm   143 TPV--------------PEVTST----YDPRPRFRYTT-------TTEPQIIKF---------VK 173

  Fly  6105 TTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTLP 6169
            ||.|:.|.|.||      |...:...||       ||.||..:|.               :|.:|
Worm   174 TTKPTTTTEDTT------TEDDIIRFTT-------TTERVRYATF---------------SPNIP 210

  Fly  6170 SDFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTA 6234
            ...:|.|     |.:|...||:...:::|..|::  ||.|:.||..||.|           :|..
Worm   211 MTTSTTP-----TTTTSTFPTSTTEKSTTAQPST--TTKPTTTSPPTTQV-----------KTIL 257

  Fly  6235 PPSEVRTTIGVEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSEQTTESTRDVPTTRPFEAS 6299
            |.:|.:...              |.| :....|||      |||   .|:.|...:.:|..|
Worm   258 PATEAQKIF--------------TKP-QYQIWPTT------TRP---MTSTSQAVISSTEQF--- 295

  Fly  6300 TPSPASL------KTTVPSVTSEATTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTD 6358
             ..|:|:      |...||||.|.||:| ..:|...||.:..|.||    ||.:...|.||..
Worm   296 -IRPSSIIRNNVWKKVTPSVTPEYTTSV-FWTTPMSVTAELPSEPS----TITMLIPTPPSEY-- 352

  Fly  6359 RTTPSESPETPTTLPS-DFTTRPHSEKTTESTRDVPTTRPFETSTPSP------ASLETTVP--- 6413
            :|..|.:...|..:.: .||..|..||.  :....|.|..::|..|..      .|.||:.|
Worm   353 QTVYSSTAGIPFIIKAKKFTRPPIVEKI--AVTSAPHTNKYDTCVPDQRCSIKLKSFETSDPLFQ 415

  Fly  6414 -----------SV-----TLETTTSVPMGSTGGQVTGQTTAPPSEVRTTIRVEESTLPSR----- 6457
                       |:     ..:|.:|:|.     .::..::..|..|:....:.....|||
Worm   416 YCYSHSTMIDNSIQDLLRDTQTASSLPQ-----HISWHSSVTPEIVQLVQTLMSLYRPSRCLVIG 475

  Fly  6458 ------------STDRTSPSESPETPT-TLPSDFITRPHSEKTTE---STRDVPTTRPFEASTPS 6506
                        ..|......:.|.|. .:..|.|.:.|:.|.|.   |...:.|:...|.|.|.
Worm   476 VFTGLGLLGVAERVDSRGIVVALEHPAYAVFWDKIGQKHARKLTATQMSRIQMRTSESIEKSLPR 540

  Fly  6507 SASSGNNCSISYFRNHYKCSN 6527
            .|::..|.....|.:.:|..|
Worm   541 LATNEPNTFDFVFLDDFKREN 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395	108/427 (25%)
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572	46/195 (24%)
		DUF4758	6181..6360	CDD:292572	51/184 (28%)
		DUF4696	6339..6999	CDD:292395	49/236 (21%)
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
comt-1	NP_508495.2	YrrM	413..634	CDD:226607	27/154 (18%)
comt-1	NP_508495.2	AdoMet_MTases	<451..633	CDD:302624	23/111 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910