DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and C31G12.4

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001368148.1	Gene:	C31G12.4 / 183093	WormBaseID:	WBGene00007853	Length:	827	Species:	Caenorhabditis elegans

Alignment Length:	522	Identity:	126/522 - (24%)
Similarity:	179/522 - (34%)	Gaps:	132/522 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly 18757 ETPKPVR--PQIYDT--PSPPYPVAIPDLVYVQQQQPGIVNIPSAPQPIYPTPQS-PQYNVNYPS 18816
            |..||:.  |::.|.  |..|.||...:||..:.:      :|...||..|.|:| ....:...:
Worm   365 ELKKPLEAGPKLPDALEPEIPKPVKTVNLVVAKAE------VPKPKQPTEPKPESIKSTEIKPKA 423

  Fly 18817 PQPANPQKPGVVNIPSVPQPVYPSPQPPVYDVNYPTTPVSQHPGVVNIPSAPRLVPPTSQRPVFI 18881
            |:...|::|..|. |.||:|.  .|:..|.|.                |.||.  |.|::    :
Worm   424 PKLQKPKQPTEVK-PEVPKPT--EPRKTVGDK----------------PKAPE--PKTAK----L 463

  Fly 18882 TSPGNLSPTP-QPGVINIPSVSQPGYPTPQSPIYDANYPTTQSPIPQQPGVVNIPSVPSPSYPA- 18944
            ..|.....|. :|   .:|.:.:|..||...|          :||.........|.:..|..||
Worm   464 AEPAKSVETEIKP---KVPKLKEPEKPTEAKP----------APIKSTEIKPKAPKLKEPEKPAE 515

  Fly 18945 PNPPVNYPTQPSPQIP--------VQPGVINI------PSAPL---PTTPPQHPPVFIPSPESPS 18992
            |.|.....|:..|:.|        .:|...:|      |.||.   |..|.:..|..|.|.|...
Worm   516 PKPESIKSTEIKPKAPKLKEPEKLAEPKPESIKWTEIKPKAPKLKEPEKPAEPKPESIKSTEIKP 580

  Fly 18993 PAPKPGVINIPSVTHPEYPTSQVPVYDVNYSTTPSPIPQKPGVVNIPSAPQPVHPAP-------- 19049
            .|||        :..||.|....|     .|...:.|  ||....:....:|..|.|
Worm   581 KAPK--------LKEPEKPAEPKP-----ESIKSTEI--KPKAPKLKEPEKPAEPKPESIKSTEI 630

  Fly 19050 NPPVHEFNYPTPPAVPQQPGVLN------IPSYPTPVAPTPQSPIYIPSQEQPKPTTRPSVINVP 19108
            .|...:...|..||.|:...:.:      .|....|..||...|..|.|.|     .:|....:.
Worm   631 KPKAPKLKEPEKPAEPKPESIKSTEIKPKAPKLKEPEKPTEDKPAPIKSTE-----NKPEAPKLQ 690

  Fly 19109 SVPQPAYPTPQAPVYDVNYPTSPSV-IPHQPGVVNIPSVPLPAPPVKQRPVFVPSPVHPTP---- 19168
            ...||..|.|::.....|.|.:|.: .|.||..|. |.||.|..|   |......|..|.|
Worm   691 KPKQPTEPKPESIKSTENKPEAPKLQKPKQPTEVK-PEVPKPTEP---RKTVGDKPKAPKPKTAK 751

  Fly 19169 --APQPGVVNIPSVAQ---PVHPTYQPP-----VVERPAIYDVYYPPPPSRPGVINIPSPPRPVY 19223
              .|...|..:|..:|   ||.||...|     ::::||           :|.:..:..|.:|..
Worm   752 LAEPAKSVEFMPKASQLREPVKPTVVEPEQNLKLLDKPA-----------QPEIAKLDEPHKPTE 805

  Fly 19224 PV 19225
            .|
Worm   806 EV 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883	17/67 (25%)
		Med25_SD1	18795..18955	CDD:288132	39/162 (24%)
		MISS	19026..19258	CDD:292450	55/229 (24%)
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
C31G12.4	NP_001368148.1	PTZ00121	<352..820	CDD:173412	126/522 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910