DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpy and C30B5.6

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001254109.1	Gene:	C30B5.6 / 183042	WormBaseID:	WBGene00016247	Length:	547	Species:	Caenorhabditis elegans

Alignment Length:	591	Identity:	132/591 - (22%)
Similarity:	199/591 - (33%)	Gaps:	207/591 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  7419 TGGQVTGQTTAPPSEVRTTIR-VEESTLPSRSTDR-----TPPSESPETPTTLPSDFTTRPHSDQ 7477
            |.|:.:...|...:.:|.:|. :.|.:|.|...|.     |.|.   .|.....|.|........
Worm    72 TVGRNSATITEEMARIRNSIEDISEFSLDSNEVDEAINDITVPY---GTKMKKSSKFAELSEIHN 133

  Fly  7478 TTESSRDVPTTQPFESSTPRPVTLEI-----AVPPVTSETTTNVPIGSTGGQVTGQTTATPSEVR 7537
            |..|::.:|   ||..|..:..::::     ||||.|  |||.:
Worm   134 TDSSNKALP---PFAFSEDQQESVDVVEKVEAVPPTT--TTTKL--------------------- 172

  Fly  7538 TTIGVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPAS 7602
                                       |||||          ||:||    |||    :|..|::
Worm   173 ---------------------------TTLPS----------TTQST----TTR----TTTQPST 192

  Fly  7603 LETT------------VPSVTLETTTNVPIGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTD 7655
            :.:|            ||..|:.:.::.||...    ||.||....|:.||      |||..:..
Worm   193 IVSTRQKYVNVDGDIYVPGKTVISVSSTPIVDR----TGTTTPVSIEISTT------TLPPMTEI 247

  Fly  7656 RTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEA-------STPRP-----VTLETA 7708
            .||..      :||.:.:|..|.....:.||..:|...|...       :||||     :|..|.
Worm   248 FTTKY------STLSTSYTHTPSPHIFSSSTVRLPIAIPIPTKLPEIMFTTPRPYRGPFITEFTI 306

  Fly  7709 VPSVTSETTTNV--PIGSTVTSETTTNVPIGSTGGQVAGQTTAPPSEVRTTIRVEESTLPSRSAD 7771
            .|. .||..|::  .|.||..........||....:.||....|.:.|.|.| .::..:..|:..
Worm   307 EPK-RSEGRTSLRDRIRSTSQLLNLLGDKIGGIDQKAAGNRAEPKTGVLTNI-YDQGVIKKRNLK 369

  Fly  7772 RT---TPSESPETPTTLPSDFT---------------------TRPHSEQTTESTRDVPTTRPFE 7812
            ..   ...|.|:...|....|:                     .||..::..:|.| :...|| |
Worm   370 TKQWGIAGEDPQGVQTYDGQFSGMAYGATKQRGGGYSMRKRMGKRPWQKRGYKSRR-LGDKRP-E 432

  Fly  7813 ASTPSPASLETTVPSVTSETTTNVPIGS-------TGGQLTEQSTSSPSEVRTTIR-VEESTLPS 7869
            ...||     |.|...|  |..:||.||       .|.:|:|:        |..:| |.|
Worm   433 YMRPS-----TFVEKRT--TDVSVPFGSHWREEWVRGVKLSER--------RNAVRNVSE----- 477

  Fly  7870 RSTDRTFPSESPEKPTTLPSDFTTRPHLEQTTESTRDVLTTRPFETSTPSPVSLETTVPSVTSE- 7933
                    ::.......|.|:..:...|::|....|:|             |.::|:  |.|::
Worm   478 --------NQKNVAQALLESEEASMRQLKKTLRKIREV-------------VKIKTS--STTADV 519

  Fly  7934 TSTNVP 7939
            |:||.|
Worm   520 TTTNKP 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395	31/160 (19%)
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395	132/591 (22%)
		DUF4758	7400..7587	CDD:292572	37/178 (21%)
		DUF4758	7538..7707	CDD:292572	45/192 (23%)
		DUF4758	7798..7979	CDD:292572	36/151 (24%)
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
C30B5.6	NP_001254109.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910