DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and F48E3.8

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001360756.1 Gene:F48E3.8 / 181010 WormBaseID:WBGene00018607 Length:2111 Species:Caenorhabditis elegans


Alignment Length:3002 Identity:626/3002 - (20%)
Similarity:882/3002 - (29%) Gaps:1301/3002 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   800 AQCMLANGQAQCLCAPGYTGNSALAGGC---NDIDECRANPCAEKAICS--NTAGGY-------L 852
            |:.||.|.    :.|...|.|.:..|..   .:.|..||...|....||  |...||       :
 Worm    11 AEIMLQNE----IMADHRTINQSFRGNFFRRRNYDGPRAYQIAPDLTCSYDNQCAGYPLAICHSV 71

  Fly   853 CQCPGGSSGDPYREGCITSKTVGCSDANPCATGETCVQDSYTGNSVCICRQGYERNSENGQCQDV 917
            |||..|:..                      ||.||:..|....:...|..|.....|.|.|..|
 Worm    72 CQCVKGALN----------------------TGTTCIASSTAIQTSVACPAGQTYIREAGVCMTV 114

  Fly   918 DECSVQRGKPACGLNALCKNL-PGSYECRCPQGHNGNPFIMCEICNTPECQCQSPYKLVGNSCVL 981
            .    |.|:| |..:..|..| ||:|                  |....|:|....|...|.|..
 Worm   115 Q----QPGEP-CQYSQQCSALEPGAY------------------CLKMRCECVYGMKKSSNGCTF 156

  Fly   982 SGCSSGQACPSGAECISIAGGVSYCACPKGYQTQPDGSCVDVDECEERGAQLCAFGAQC--VNKP 1044
            ..                                        ::|:|||....:...:|  |..|
 Worm   157 VN----------------------------------------NDCKERGHIFISEIGECREVFPP 181

  Fly  1045 GSYSCHCPEGYQGDAYNGLCALAQRKCAADRECAANEKCIQPGECVCPP--PYFLDPQDNNKCKS 1107
            |...|         ::|..|:.|.    .|..|...       .|.|||  |...|......|  
 Worm   182 GGKGC---------SHNLQCSGAY----PDATCFMQ-------TCTCPPNLPVAADGTCGRSC-- 224

  Fly  1108 PCERFPCGINAKCTPSDPP--QCM----CEAGFKGDPLLGCTDEDEC--------SHLPCAYGAY 1158
            |..:...|:..:|.|...|  .|:    |:|.|.|   |.| |::.|        ..|.|::|  
 Worm   225 PNNQVYSGVTGECLPEKQPGQDCIYSSQCQASFGG---LVC-DKNTCRCPNGLVFDGLKCSHG-- 283

  Fly  1159 CVNKKGGYQCVCPKDYTGDPYKSGCIFESGTPKSKCLSNDDCASNLACLEGSCVSPCSSLLCGSN 1223
                       ||      |:|.  :.:    |..|:  :.|.|.:..:.|.||...|       
 Worm   284 -----------CP------PHKR--VID----KEICV--EGCPSGIVEVAGRCVKQVS------- 316

  Fly  1224 AYCETEQHAGWCRCRVGYVKNGDGDCVSQCQDVICGDGALCIPTSEGPTCKCPQGQLGNPFPGGS 1288
                           :|.      .||:..|   |..|:.|    :..||:||        ||..
 Worm   317 ---------------IGQ------PCVANAQ---CNFGSFC----QSGTCQCP--------PGFY 345

  Fly  1289 CSTDQCSA--ARPCGERQICINGRCKERC-EGVVCGIGATCDRNNGKCICEPNFVGNPDLICMPP 1350
            ...:||.|  :.|   .:.|.|   .|:| :|.||        .||||.|..|.    :||    
 Worm   346 VQDEQCQAIESEP---NESCQN---NEKCTKGSVC--------YNGKCSCPRNH----ELI---- 388

  Fly  1351 IEQAKCSPGCGENAHCEYGLGQSRCACNPGTFGNPYEGC-------GAQSK---------NVCQP 1399
                        |.||:    |:|.|.:  .:....|..       .:|||         :|...
 Worm   389 ------------NGHCQ----QNRAAAH--AYNTALENIRKIRLRFASQSKSRNSSPQLTDVEND 435

  Fly  1400 NSCGP-NAECRAVGNHIS---------CLCPQG-----------FSGNPYIGCQDVDECANKPCG 1443
            |...| .:.|..:|....         |:||.|           .:..|...||:.:||.:    
 Worm   436 NDTVPIGSACVRIGVTCDGGSVCVAGICVCPLGKTPRNGVCIEHVAARPGTSCQNEEECVD---- 496

  Fly  1444 LNAACLNRAGGFECLCLSGHAGNPYSSCQPIESKFCQDANKC------------QCNERVECPEG 1496
                                    :|.|.|       :.|||            :|.||::...|
 Worm   497 ------------------------HSYCSP-------ETNKCECMKASQMVIGGECRERLKAHPG 530

  Fly  1497 YSCQKGQCKNLCSQASCGPRAICDAGNCICPMGYIGDPHDQVHGCSIRGQCGNDADCLHSEICFQ 1561
            |.|..|:        .|...::|..|.|.|..|.:          .|...|.:.......:.|  
 Worm   531 YGCTMGE--------MCVGNSVCVNGKCACVDGKV----------EINKICIDQVSAKPGDTC-- 575

  Fly  1562 LGKGLRKCVDACSKIQCGPNALCVSEDHRSSCICSDGFFGNPSNLQVGCQPERTVPEEEDKCKSD 1626
             |||:                           ||..|.:.|               .:..||.  
 Worm   576 -GKGI---------------------------ICEGGSYCN---------------TDSGKCA-- 595

  Fly  1627 QDCSRGYGCQASVNGIKECI------NLCSNVV--CGPNELCKINPAGHAICNCAESYVWNPVVS 1683
              |.||   :.|:|||.:..      :||:::.  |.....|     ....|.|.      |.:|
 Worm   596 --CRRG---ENSINGICKGFTFVYPGDLCTDITSRCTGGSYC-----ARGRCECP------PRMS 644

  Fly  1684 SCEKPSLPDCTSDAN--CPDASACRPDVLGVLKCVAICDAFTCPANSVCVARQHQGRCDCLNGFV 1746
            :.:|..:...|:...  |.:..||.|        .::|:      |:|         |.|:|..:
 Worm   645 AIDKKCVHQQTAAPGEPCSEKVACSP--------FSVCE------NNV---------CKCVNNMM 686

  Fly  1747 GNPNDRNGCQPAQKHHCRNHAECQESEACIKDESTQTLGCRPACDTVKCGPRAVCVTNNHQAQCQ 1811
              ..|:. |...:|.:..|  .|...:.|:.:                    :.|:.||    ||
 Worm   687 --IRDKM-CVQRRKVNIGN--SCNNEDQCLGN--------------------STCMDNN----CQ 722

  Fly  1812 CPPGPFAGDPYDPFNGCQSVPCVYNHDCPPSQMCNRMTHTCFDVCDEESCGDNAICLAEDHRAVC 1876
            |..|         |.....| ||......|..:||          .|:.|...::|:    :.||
 Worm   723 CGIG---------FVASMDV-CVLRKTVTPGYLCN----------PEDICTGQSVCI----KGVC 763

  Fly  1877 QCPP--------------GFKGDPLPEVACTKQGGCAAG-TCHPSAICEVTPEGPVCKCPPLFVG 1926
            ||.|              |.:|.|     |:.:..|..| .|..|..|. .|||       ||..
 Worm   764 QCQPDYKQMHNICVKKNIGIEGSP-----CSSRDDCGEGLMCGASGKCS-CPEG-------LFSV 815

  Fly  1927 DAKSGG-------CRPDGQCPNGDADCPANTI------------CAGGVCQNPCD---------- 1962
            :.|...       |..|.:|...:|.|..|..            ||..:. .|.:          
 Worm   816 NGKCRSYVQLGQTCTSDDRCAERNAQCQENYCTCRTGYTNINGQCAANIV-TPAEPETLSQVKSG 879

  Fly  1963 ---NACGSNAECKVIN---RKPVCSCPLRFQPISDT----------------------AKDGCAR 1999
               :.|.||..||:.:   |:.||.|...::....|                      ..|.|.:
 Worm   880 LLGHICTSNDHCKIAHSQCRRNVCQCIDGYRIFGSTQCIPRPGKPKERKTEKESKLVELGDKCDK 944

  Fly  2000 TISKCLTDVDCGGALCYNGQCRIACRNSQDCSDGESCLKNVCVV--------ACLDHSQCASGLA 2056
             :|.|     ..||:|..|.|  :|..:...||| :|:|||..:        :||...:|:....
 Worm   945 -LSLC-----SKGAICEKGVC--SCPETFFESDG-ACVKNVAKIKVVVPPLSSCLGGEECSGNSE 1000

  Fly  2057 CVEGHCTIGCRSNKECKQDQSCIENKC------------------------LNPCQSANS----- 2092
            ||.|.|.        ||::.:..|.||                        ..|..::|:     
 Worm  1001 CVHGICF--------CKEEFTLFEGKCQRLRIIEKLTVLESKKLIKPIKAHTTPTAASNTTPIPV 1057

  Fly  2093 --------------------------------------------------------CGPNALCSI 2101
                                                                    ..|..:|..
 Worm  1058 KTTTTLQTTTATTLPENYVSSSTNRPLTPIIISMKLGSTSSPSPQITSNPEYKWRLSKPGHMCDN 1122

  Fly  2102 DQHHSQCS--------CPEGF--EGNPTPEQGCV-RVPA-PCLASNQCPSGHMCIGNQCN----- 2149
            ..|.:.||        ||||.  .|:.     || .:.| .||||||||||..|:..:|.     
 Worm  1123 KTHCTNCSVCVNGFCRCPEGLVHYGDK-----CVSEIDATKCLASNQCPSGAQCVKGECRCKPGL 1182

  Fly  2150 --------LPCT---KTASCAVGERCYQQ--------VCRK-VCYTSNNCLA------------- 2181
                    :|.|   ...|||.||.|.:.        .|.: :....|.|:.             
 Worm  1183 GITRYGFCVPITFAEPGTSCAYGEHCQKDSHCEDGLCTCNEPLVLKENKCVVSPREKRFISDVHR 1247

  Fly  2182 -------------GEIC--NSDRTCQPGCDSDADCPPTELCLTGKCKCATGFIGTPFGC------ 2225
                         ||.|  ||.      |:|...      ||...||||:.|:.:.|.|      
 Worm  1248 KLLRFTPKKLAKLGEYCFRNSH------CESQRQ------CLKNVCKCASNFVQSSFSCVPRMSV 1300

  Fly  2226 -SDI----DECTEQPCHASARCENLPGTYRCVCPEGTVGDGYSQPGCSQPRQCHKPDDCANNLAC 2285
             |.:    :.|.:..|...:.|||    :.|.||     |.|.:.|          |.|....:.
 Worm  1301 ISSLALPGESCRKGFCVGGSTCEN----FMCKCP-----DDYFKKG----------DSCVRYESR 1346

  Fly  2286 IHGKCTDPCLHTVCGINANCQSEGHEALCSCPAGFLGDPNDTGVGCFKVECIDHVDCAGDRACDA 2350
            |...|...   :.|...|.|.|    :.|.|.     |..|..|.    ||..:......|...|
 Worm  1347 IGAACGTA---SGCSGGATCTS----SFCQCQ-----DQYDADVD----ECYPYEPSVRSRNVKA 1395

  Fly  2351 -----ETNRCIKPCDLTSCGKGNCQVRDHKATCACYEGYQLVNDVCEDINECLSQPCHSTAFCNN 2410
                 :.||.:      |....||.:           ||.|||.:|.: :|.||      .....
 Worm  1396 ISGRRKVNRVV------SASTINCPI-----------GYDLVNGMCVN-SETLS------VIQLA 1436

  Fly  2411 LPGSYSCQCPEGLI---GDPLQAGCRDPNECLSDADCPASASCQNSRCRSPCERQNACGLNANCQ 2472
            .||.   .|.:|.|   |:.:.|.    |.|:    ||...:.||..|.|         :|.   
 Worm  1437 APGG---ACEDGTILCTGNSVCAN----NVCI----CPGGETVQNGTCVS---------INT--- 1478

  Fly  2473 AQAHQAICTCPLNSRGDPTIECVHIEC-ADNDDCSGEKACLDSKCIDPCSLPNACGAL-ARCSVQ 2535
                       .:|.|||        | ..|..|:|...|:|.    .|..||..||: .|||  
 Worm  1479 -----------YSSPGDP--------CDLTNTICTGNSQCIDG----ICKCPNNQGAINGRCS-- 1518

  Fly  2536 NHIGVCSCEAGSTGDAKLGCVQLQYCQQDGQCAQGSICSHGICSPLCSTNRDCISEQLCLQGVCQ 2600
                       :.|:|..|.:|                        |.||      |:|:|..||
 Worm  1519 -----------NMGNANCGNIQ------------------------CGTN------QICIQDSCQ 1542

  Fly  2601 ---GTCKSNSSCPQFQFCSNNICTKELECRSDSECGEDETCLSDAYGRAKCESVCLGRAACGRNA 2662
               |..:...||.|.: |:   |.:|:|  |||                     ||.| .||.|.
 Worm  1543 CRPGYYQQPGSCLQDR-CN---CIQEVE--SDS---------------------CLNR-QCGMNQ 1579

  Fly  2663 ECVARSHAPDCLCKEGFFGDAKSGCRKIECTSDDDCSNDKSCDNHMCKIACLIG---QPCGENAL 2724
            .|:    ...|.|:.|:.            ...:.|.:|: |:.....:..:.|   ..||.|.:
 Worm  1580 VCI----QDQCQCRSGYL------------VLQETCISDR-CNCVQPSVDAISGGCMNQCGNNQV 1627

  Fly  2725 CTTEHHQQVCHCQPGFSGDPRVRCDVIDFCRDAPCGPGARCRNARGSYKCTCPPGLVGDPYNEGC 2789
            |.    |..|.|:.|:...|..                  |...|    |.|...:|.|..|   
 Worm  1628 CI----QDQCLCRNGYYAQPET------------------CTGDR----CNCVQHVVPDMGN--- 1663

  Fly  2790 RSSVECETNEDCPPHAACTKTNGVAKCRDVCAQLQCGPNAECVPKGHVAQCACRSGYDGQP---- 2850
                                           .|.|||.|..|:..    ||.||:||..|.    
 Worm  1664 -------------------------------CQRQCGNNQVCIQD----QCQCRNGYYAQTETCV 1693

  Fly  2851 ADR---VAGCKPLPSPCQVTGDCPTNTYCSDSVCKPACVLDTECGAFEVCQGGQCFNPCLQPQA- 2911
            ||:   |.....:||||...|            |.|:....:.. .|....|..|   .|:|.| 
 Worm  1694 ADKCNCVQRAVAIPSPCVGNG------------CAPSAQSQSYL-QFIGLPGKMC---DLRPNAI 1742

  Fly  2912 -CGQNAECVMQNHLKQCHCPEGFTGDSAKECVRVPVACDGECGPGYTCRDSMCLPVCHNDLECAS 2975
             |..:|:|| .|:   |.||.... .|...||...    |:..||.:|:        :|.:.|..
 Worm  1743 PCRNDAQCV-NNY---CICPSNRV-ISGSNCVFYL----GDALPGQSCQ--------NNGMICRG 1790

  Fly  2976 NEKCLKGSCMLTCRVDNDCFLGHVCLHNKCVYGCHVDDDCSASESCRNDKCVNPCLENPCGPNAA 3040
            ...|.:..|                   :|..|..||          |.:| .|.:|        
 Worm  1791 GSSCNQNIC-------------------QCAVGFSVD----------NGRC-TPTIE-------- 1817

  Fly  3041 CSVSNHRASCSCLESMVP------NP--TPQVGCVRSPPLECRENRDCGNGLACFESVCRPLCAD 3097
                 .|.:...:.:.:|      ||  |....|...|   |.:.  |..|.:|..|:|.  |..
 Worm  1818 -----VRFTMLPVTTAIPVFIIELNPGQTCDPSCAYQP---CMQR--CSGGSSCSNSICS--CPQ 1870

  Fly  3098 DAGCLTNERCQQGVCKP-LCRHDNECGHGELCLGLNCVPGCRSDQGCPPELSCV-GQQCVDPCAD 3160
            .:|.|.|      ||.| ..::||          .|.....|....|...:.|: |..|:     
 Worm  1871 GSGVLNN------VCSPSFPQNDN----------YNLTRTARPGDSCDNTIVCIGGSSCL----- 1914

  Fly  3161 PTACGTNAHCQTIDHRKQCLCPEGLDGNANVACKVPRIACGRNEDCQSNQLCYAGSCQGKCRNDQ 3225
               .||            |||..|.:.:::      |.:|..|:........|.           
 Worm  1915 ---IGT------------CLCDSGYEPSSD------RSSCVLNDRYNVRSRSYP----------- 1947

  Fly  3226 NCLADERCMRGTCRTVCNTDEACAQGQICENRMCQTGCRTDLSCATDEACVNKKCQ------NPC 3284
                         :|.|..|..|..|.||.::.|        :|..|...:|..||      :.|
 Worm  1948 -------------KTFCTFDSECTGGSICIDKRC--------ACRNDHEMINGVCQLANLPGSRC 1991

  Fly  3285 RTPGQCGQCADCLVVNHGVQCQCPAAFMGDGLTGCQLPPERCHPDCECDENG-----AYCAPKCS 3344
            .| ..|.:.|:|   .:| .|.|......|...           ||....|.     ||...||:
 Worm  1992 HT-SFCSKGAEC---RNG-YCVCAKTNYSDSTL-----------DCVSSINANQGSMAYPGSKCN 2040

  Fly  3345 RTEDCACGQQCARGKC-------------------RNKCGPKRQCTVGQLCERGACIAGCKSNGD 3390
            .|..|.....|..|.|                   :.|||..:.|...|.|.....   |    :
 Worm  2041 ATTSCQQNSSCFFGYCVTPQDEIDREANIKIRHIEKKKCGSYKDCGKSQTCSSDRL---C----E 2098

  Fly  3391 CAADQSCVNGKC 3402
            |..:.:.|||:|
 Worm  2099 CTFNTNLVNGEC 2110

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542 9/35 (26%)
EGF_CA 2227..2260 CDD:238011 8/36 (22%)
EGF_CA 2393..>2422 CDD:214542 6/28 (21%)
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
F48E3.8NP_001360756.1 EB 98..154 CDD:366756 20/78 (26%)
EB 224..280 CDD:366756 16/61 (26%)
EB 300..351 CDD:366756 19/93 (20%)
EB 340..392 CDD:366756 24/93 (26%)
EB <438..476 CDD:366756 7/37 (19%)
EB 514..563 CDD:366756 14/66 (21%)
EB 552..607 CDD:366756 20/116 (17%)
EB 596..650 CDD:366756 16/67 (24%)
EB 639..692 CDD:366756 16/84 (19%)
EB 681..734 CDD:366756 17/91 (19%)
EB 723..776 CDD:366756 17/76 (22%)
EB 808..860 CDD:366756 12/58 (21%)
EB 961..1019 CDD:366756 18/66 (27%)
EB <1111..1150 CDD:366756 10/43 (23%)
EB 1283..1340 CDD:366756 18/75 (24%)
EB 1413..1473 CDD:366756 23/88 (26%)
EB 1462..1517 CDD:366756 22/89 (25%)
EB 1757..1812 CDD:366756 18/96 (19%)
EB <1893..1930 CDD:366756 11/62 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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