DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and nid-1

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001256465.1 Gene:nid-1 / 179770 WormBaseID:WBGene00003738 Length:1584 Species:Caenorhabditis elegans


Alignment Length:1893 Identity:392/1893 - (20%)
Similarity:545/1893 - (28%) Gaps:739/1893 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   218 NPENCGPNA-----LCTNTPGNYTCSCPDGYVGNNPYREGCQDVDECSYPNVCGPGAICTNLEGS 277
            |..:.||:.     |..|..||:......|....:|..||..|.|..:|..         ..||.
 Worm   200 NVNSGGPDVKELVNLSNNQFGNFFIFRVSGSAIEDPKDEGADDYDYNNYDQ---------EYEGE 255

  Fly   278 YRCDCP--------PGYDGDGRSESGCVDQDECARTPCGRNADCLNTDGSFRCLCPDGYSGDPMN 334
            :..|||        |......|.|.|| ::..||..|....|             |.....:..|
 Worm   256 HPADCPKDKFVDNCPAECRTVRDERGC-ERCICAERPHAPRA-------------PQEPRPELEN 306

  Fly   335 GCED------VDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHDPHADQLPQPLNTQQLGYGP 393
            ..||      ||......|.....|                     .|..|..||...||     
 Worm   307 TVEDDEDDEQVDGTRYEEPARQAQE---------------------QHHQQHHQPDQPQQ----- 345

  Fly   394 GATDIAPYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQGYLHCENI 458
                 .|.:...|:    |....|:|.|. ..|..|:.|.:|.|.:.|.|.:||.|.|       
 Worm   346 -----QPQRSQEGS----LPKMSCSQRDD-KSCHANSVCQDFEGGFCCNCDTGFYGNG------- 393

  Fly   459 NECQDNPCGE----------------------NAICTDTVGSFVCTCK--PDYTGDPFRGCVDID 499
            .||.  |.||                      :...|.|.|:......  |...|.|.|....| 
 Worm   394 KECL--PKGEPQRISGSFEGVINRIPIDKTELHTFATSTDGNVHTAVSKIPSDLGHPLRFLYSI- 455

  Fly   500 ECTALDKPCGQHAVCENTVPGY---NCKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTNN---- 557
                            ..|.|:   :.:.|..|:|                    |..|..    
 Worm   456 ----------------GGVMGWLFADVQSPNVYNG--------------------FQLTGGLFNR 484

  Fly   558 --AECIENQCFCLDGFEPIGSSCVDIDECRTHAEVCGPHAQCLNTPGSYGCECEAGYVGSPPRMA 620
              |..||...:.....|..|.:..|.  .::|..|.|                            
 Worm   485 TVALHIEQNYYVTIKQEFSGRNIHDY--FKSHLFVSG---------------------------- 519

  Fly   621 CKQPCEDVRCGAHAYCKPDQNEAYCVCEDGWTYNPSDVAAGCVDIDECDVMHGPFGSCGQNAT-- 683
               ...|:..|:.... ||..|.|.....|  |..|..|...:..|..:|..... |..|..|  
 Worm   520 ---TLPDIAPGSEVIF-PDYEEEYVRERRG--YLTSKAAFDVIVRDGGNVQTYRM-SVDQQITFE 577

  Fly   684 -CTNSAGGFTCACPPGFSGDP----HSKCVDV----DECRTGASKCGAG-------AECVNVPGG 732
             |.|..          |..|.    |.|.::|    ||   |..:.||.       ...|:.|.|
 Worm   578 ECPNKE----------FDRDHSMKLHVKRINVVYNDDE---GVVRYGAKNFATRSVGPAVSAPSG 629

  Fly   733 GYTCR---CPGNTIADPDPSVRCVPIVSCSANEDCPGNSICDATKRCLCPEPNIGNDCRHPCEAL 794
            |:..|   ...|..::.       ||...|.:|....:|:| |..|..|..||:           
 Worm   630 GHFDRRQHGQSNMASER-------PIEIPSQSESISTDSVC-APGRHQCTLPNM----------- 675

  Fly   795 NCGAHAQCMLANGQAQCLCAPGY----TGNSALAGGCNDIDECRA--NPCAEKAICSNTAGGYLC 853
                  :|.:.:...:|.|.|||    ..:|.:...|.|:|||:.  :.|.:.|.|:|..|.:.|
 Worm   676 ------KCRVVDPSYRCECEPGYQAAHDASSHIGWICQDLDECQRGDHNCDQHAKCTNRPGSFSC 734

  Fly   854 QCPGGSSGD-------------------PYREGCITSKTVG-CSDANPCATGETCVQDSYTGNSV 898
            ||..|..||                   |.....:.:.|.| |:..|.|.....||..|......
 Worm   735 QCLQGYQGDGRSCIREHQASHHEHNQQTPQEMAGVGATTEGFCTAHNQCHQWGECVFTSEHPTGR 799

  Fly   899 CICRQGYERNSENGQCQDVDE------CSV-QRGKPACG-----LNALCKNLP-GSYECRCPQGH 950
            |.||..|..:..| .|...:|      .:: |||..|||     :||.|...| |..||.|..|.
 Worm   800 CKCRGWYVGDGVN-HCGPPEENMPKHNANIPQRGGQACGSYVCDVNAECMPEPSGGSECVCKAGF 863

  Fly   951 NGNPFIMCEICNTPECQCQSPYKLVGNSCVLSGCSSGQACPSGAECISIAGG-VSYCACPKGYQT 1014
            :||                                       |..|.|:... .::.:..:..|.
 Worm   864 SGN---------------------------------------GVTCESLLDDRHAHSSHNRHEQQ 889

  Fly  1015 QPDGS----CVDVDECEERGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYNGL-CALAQRKCAA- 1073
            |..||    |...|||.|.|:  ||:.    :..|.|.|.|.|.|.|   ||: |.|.....:| 
 Worm   890 QQTGSLGKVCRSHDECSEHGS--CAYH----HSLGYYQCACTEPYVG---NGVECTLPGSSASAP 945

  Fly  1074 DRECAANEKCIQPGECVCPPPYFLDPQDNNKCKSPCERFPCGINAKCTPSDPPQCMCEAGFKGDP 1138
            :..|.....|.:..:||                  .||...|...:        |:|::|:.|| 
 Worm   946 ELGCDVTRDCSEFADCV------------------YERSSTGATFR--------CVCQSGYTGD- 983

  Fly  1139 LLGCTDEDECSHLPCAYGAYCVNKKGGYQCVCPK--DYTGDPYKSGCIFESGTPKSKCLSNDDCA 1201
                             |.||:..:.....:.|.  ....:|              ..||...|.
 Worm   984 -----------------GKYCMQSQLAISAISPSVPQLPSEP--------------AVLSTASCN 1017

  Fly  1202 SNLACLEGSCVSPCSSLLCGSNAYCETEQHAGWCRCRVGYVKNGDGDCVSQCQDVICGDGALCIP 1266
            .|                ||.:|.|..:.|....||              :|.....|||..|:|
 Worm  1018 PN----------------CGPDAQCVYDDHNRQYRC--------------ECYAAFMGDGYNCVP 1052

  Fly  1267 TSEGPTCKCPQGQLGNPFPGGSCSTDQCSAARPCGERQICINGRCKERCEGVVCGIGATCDRNNG 1331
                                                                             
 Worm  1053 ----------------------------------------------------------------- 1052

  Fly  1332 KCICEPNFVGNPDLICMPPIEQAKC--SPGCGENAHC---EYGLGQSRCACNPGTFGNPYEGC-G 1390
              :.:||.|         |.:...|  |..|..|.||   |:|.|:..|.|.||..|:.:..| |
 Worm  1053 --LAKPNMV---------PAQPKTCVESSDCHINGHCVINEHGAGEYICQCLPGFSGDGFINCRG 1106

  Fly  1391 AQSKNVCQPNSCGPNAEC--RAVGNHISCLCPQGFSGN-----PYIGCQDVDECANKP--CGLNA 1446
            |...|...|::|..||.|  .|:.|..:|.|..||.|:     ||   .....|..:|  |..||
 Worm  1107 ADQCNPSNPSACYQNAHCVYDAILNAHACKCVDGFKGDGTSCVPY---APATNCNLEPRICHANA 1168

  Fly  1447 ACL--NRAGGFECLCLSGHAGNPYSSCQPIESKFCQDANKCQCNERVECPEGYSCQKGQCKNLCS 1509
            .|:  :....:||:|..|.:|:.|:.|..||:.                         :|.|...
 Worm  1169 QCVMHHDTNAYECICKPGSSGDGYTKCDVIETP-------------------------RCTNCSI 1208

  Fly  1510 QASCGPRAICDAGNCICPMGYIGDPHDQVHGCSIRGQCGNDADCLHSEICFQLGKGLRKCVDACS 1574
            .|.|.......|..|.|..||.|:.|                      :|..:.    .|:|  .
 Worm  1209 HAYCAQNPTSGAYQCKCNAGYNGNGH----------------------LCVSMS----SCLD--D 1245

  Fly  1575 KIQCGPNALCV-SEDHRSSCICSDGFFGNPSNLQVGCQPERTVPEE-----------EDKCKSDQ 1627
            :..|..||.|| .|.....|.|..|:.|:..:    |.||.:...:           |.....|:
 Worm  1246 RSLCDENADCVPGEAGHYVCNCHYGYHGDGRS----CSPESSTRSDKLLVARGMAIFERSTNPDE 1306

  Fly  1628 DCSRGYGCQASVNGIKECINLCSNVVCGPNELCKINPAGHAICNCA------ESYVWNPVVSSCE 1686
                 ||.|..|  |...|.:..:..|...::...:.:||:|...:      :|| :|..:||.|
 Worm  1307 -----YGKQLIV--IPHHIPVGIDFDCKEEKIVWSDMSGHSIRTSSLNGTEHKSY-FNKELSSPE 1363

  Fly  1687 KPSLPDCTSDANCPDASACRPDVLGV------LKCVAICDAFTCPANSVC--------VARQHQ- 1736
            ..::...:.:....|:   ..|.:||      .|...:.:....|.:.|.        .:..|: 
 Worm  1364 GIAVDWSSRNVYYADS---MNDEIGVASLNGKFKKSLVTEGLVNPRSVVLDLYGRHLYYSDWHRE 1425

  Fly  1737 ----GRCD---------------CLNGFVGNPNDRNGCQPAQKHHCRNHAECQESEACIKDESTQ 1782
                ||.|               ..||....||.|                    |.|..|....
 Worm  1426 NPYIGRVDMDGKNNRVFLNEDVHLPNGLTILPNRR--------------------ELCWVDAGNH 1470

  Fly  1783 TLGCRPACDTVKCGPRAVCVTNNHQAQCQCPPGPFA-------------------------GDPY 1822
            .|.|   ......|.|.|..:..:         ||.                         |:.|
 Worm  1471 RLSC---IQYNGAGRRTVFSSLQY---------PFGLTHDEEQKFYWTDWKDNRIHSVGVYGEGY 1523

  Fly  1823 DPFN----------GCQSVP--CVYNHDCPPSQMCNRMTHTCFDVCDEESCGDNAICLAEDHRAV 1875
            ..|.          |..:||  ||     .||..|:           |::.|...:||...:.||
 Worm  1524 RSFQISLGGSGKVFGILAVPKSCV-----GPSTPCS-----------EDNGGCQHLCLPGQNGAV 1572

  Fly  1876 CQCPPGFK 1883
            |:||...|
 Worm  1573 CECPDNVK 1580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011 8/33 (24%)
EGF_CA 255..>286 CDD:214542 9/38 (24%)
EGF_CA 298..331 CDD:238011 5/32 (16%)
EGF_CA 338..373 CDD:238011 5/40 (13%)
EGF_CA 413..456 CDD:238011 14/42 (33%)
EGF_CA 457..490 CDD:238011 9/56 (16%)
EGF_CA 497..>529 CDD:214542 4/34 (12%)
EGF_CA 580..>612 CDD:214542 4/31 (13%)
EGF_3 676..702 CDD:289699 6/28 (21%)
EGF_CA 1022..1056 CDD:214542 12/33 (36%)
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
nid-1NP_001256465.1 NIDO 93..232 CDD:214712 8/31 (26%)
G2F 398..629 CDD:214774 56/317 (18%)
EGF_3 712..747 CDD:289699 12/34 (35%)
EGF_3 841..870 CDD:289699 12/67 (18%)
EGF_CA 954..987 CDD:304395 12/76 (16%)
EGF_CA 1205..1236 CDD:304395 10/52 (19%)
EGF_3 1242..1278 CDD:289699 12/41 (29%)
NHL <1319..1513 CDD:302697 36/229 (16%)
NHL repeat 1319..1354 CDD:271320 4/34 (12%)
NHL repeat 1362..1399 CDD:271320 6/39 (15%)
NHL repeat 1402..1445 CDD:271320 6/42 (14%)
NHL repeat 1450..1482 CDD:271320 10/54 (19%)
NHL repeat 1490..1513 CDD:271320 2/31 (6%)
FXa_inhibition 1553..>1580 CDD:291342 10/37 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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