DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and clec-223

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_505863.2	Gene:	clec-223 / 179561	WormBaseID:	WBGene00007282	Length:	1034	Species:	Caenorhabditis elegans

Alignment Length:	1233	Identity:	293/1233 - (23%)
Similarity:	418/1233 - (33%)	Gaps:	405/1233 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  7357 PETPTT-LPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTSVPMGSTG 7420
            |..|.. .|.|:....:|.:.           .:....|.|..||.. |.         |.|..|
Worm    36 PPPPNVYYPPDYIYEDYSPED-----------DYYQGPPGPPGLEGP-PG---------PNGPPG 79

  Fly  7421 GQVTGQTTAPPSEVRTTIRVEESTLPSRSTDRT-PPSESPETPTTLPSDFTTRPHSDQTTESSRD 7484
            .........||:|..|:     :|..|.:|:.| .||.|.|||||                .|..
Worm    80 PDGPPGPPGPPAEKSTS-----TTTVSPTTESTAAPSTSTETPTT----------------ESTA 123

  Fly  7485 VPTTQPFESSTPRPVTLEIAVPPVTSETTTNVPIGSTGGQVTGQTTATPSEVRTTIGVEESTLPS 7549
            .|:|     ||..|.|...|.|..::||.|.            ::||.||....|...|.:..||
Worm   124 APST-----STETPTTESTAAPSTSTETPTT------------ESTAAPSTSTETPTTESTAAPS 171

  Fly  7550 RSTDRTT------PSESPETPTT----LPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLE 7604
            .||:..|      ||.|.|||||    .||..|..|    |||||. .|:|     ||.:|.:..
Worm   172 TSTETPTTESTAAPSTSTETPTTESTAAPSTSTETP----TTESTA-APST-----STETPTTES 226

  Fly  7605 TTVPSVTLETTTNVPIGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTT------PSESP 7663
            |..||.:.||.|.            ::||.||....|...|.:..||.||:..|      ||.|.
Worm   227 TAAPSTSTETPTT------------ESTAAPSTSTETPTTESTAAPSTSTETPTTESTAAPSTST 279

  Fly  7664 ETPTT----LPSDFTTRPHSDQTTESTRDVPTTRPFEASTPRPVTLETAVPSVTSETTTNVPIGS 7724
            |||||    .||..|..|    |||||. .|:|     ||..|.|..||.||.::||.|.   .|
Worm   280 ETPTTESTAAPSTSTETP----TTESTA-APST-----STETPTTESTAAPSTSTETPTT---ES 331

  Fly  7725 TVTSETTTNVPIGSTGGQVAGQTTAPPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDF 7789
            |....|:|..|                    ||    |||        ..||.|.|||||..:..
Worm   332 TAAPSTSTETP--------------------TT----EST--------AAPSTSTETPTTKTTIG 364

  Fly  7790 TTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGS-----------TGG 7843
            :|...|:...|:..|....:....:.|.    :|....:.|..|::....|           ||.
Worm   365 STSTISQSCIETECDDGWIKTLRGNNPQ----KTLCMKLFSHDTSSYDDASMYCYDSHQAFLTGP 425

  Fly  7844 --------------QLTEQSTSSPSEV-----RTTIRVEESTLPSRSTDRTFPSESPE------- 7882
                          .:::|.:.|.|.:     |||    |.|..|...|:......|:
Worm   426 DSNDEYDKIMEQALNISDQVSDSQSMILIGLKRTT----ECTTDSGEQDQNSICRRPKGFIWQDG 486

  Fly  7883 ----KPTTLPSDFTTRPHLEQTTESTR---DVLTTRPFETSTPSPVSLETTVPSVTS-ETSTNVP 7939
                ..|.:...|...|.:|.:.:..|   .::..:. .|:..:..||:.:....:| |.|..|.
Worm   487 LGETSNTLINQHFNDDPGVETSPDHVRACTGIIIVKG-ATNNKNVYSLDCSNGEKSSGEKSKMVV 550

  Fly  7940 IGSTGGQVTEQTTAPPSVRTTETIVKSTHPAVSPDTTIPSEIPATRVPLESTTRLYTDQTIPPGS 8004
            .|..|       ..|   .||.:.:.:|..|.|...::.|.|      |.||            :
Worm   551 CGKLG-------KCP---ATTPSTISTTSGASSSTASVSSTI------LSST------------A 587

  Fly  8005 TDRTTSSERPDESTRLTSEESTETTRPVPTVSPRDALETTVTSLITETTKTTSGGTPRGQVTERT 8069
            |...||:.        |:|:|:.||...||   .:|..|| |::||    ||||.|.....|:..
Worm   588 TTMVTSTP--------TTEKSSTTTTSTPT---SEATSTT-TAMIT----TTSGTTENPTTTDCP 636

  Fly  8070 TK--SVSELTTGRSSDVVTERTMPSNISSTTTVF--------NNSEPVSDNLPTTISITVTDSPT 8124
            ||  ......|.|:..|...|           ||        :.|:...:...:|:|....::..
Worm   637 TKVCRYGFHPTIRNGKVWCIR-----------VFFHFVLNYQDGSDYCWNYFHSTLSGPADENEY 690

  Fly  8125 TVPVPTCKTDYDCLDEQT-------CIGGQCISPCEYFTNLCTVQNLTICRTL-NHTTKCYCDTD 8181
            .|.:...|||...:...|       .:|.|....|.|.::....:..:..:.| |.|...|..|.
Worm   691 NVLLDQTKTDPSLVQSLTKYTKVFMVLGAQRTPACLYESSSAQCEKPSGYQWLDNVTDTTYAFTK 755

  Fly  8182 DDVNRPDCSMKAEIGCASSDECPSQ-QACINALCVDPCTFNNPCSRNED------CR-------- 8231
            .:.::||.|             |.| :.|:..|     .:.:|..|:::      |.
Worm   756 FNEDQPDTS-------------PEQPEGCVGVL-----VYTDPTKRDKELVWSLSCNDAQSAHQV 802

  Fly  8232 -----VFNHQPLCSAEHGRTPGCEHCPPGANCDPTTGACIKANVTITTITTKNSTSTKIPTKP-- 8289
                 |..|:.:|..|       ...||.:....||   :|:.   ||.||..||:.|:..|.
Worm   803 VLKLVVCGHEGVCPEE-------STIPPPSTQSTTT---MKST---TTATTSMSTTKKVCAKSDL 854

  Fly  8290 ----------RTTANP---------NTGVKTTPTTTRVT------TRNTTTTTTTTTTSSTSTES 8329
                      ||:.||         |...:.:......:      ..|.|........:..:.:.
Worm   855 KCANGWTSFNRTSTNPFCFKVISSYNQSYEQSEALCAASGGYLSGVENITEYQFAVELAKAAVDY 919

  Fly  8330 ST-------ITSATN------QTSKNQKPDT-------ESTTSHTDATRRYRDGENN----ITDT 8370
            ||       :|.|..      ||...:...|       :..|.:....:.|....:|    |:|.
Worm   920 STSFNEKILVTIALKRKVICLQTDSTESCITFKAYEFVDDKTKYVAILQHYSLWADNQPVIISDQ 984

  Fly  8371 PTPRPTIQTTTLRGEGVMGDSQRRSTTT---PKMKTTRLDTSNE------------VPDTTSP 8418
            |             .|.:|....:||:|   .|:.:||.:|..:            |||...|
Worm   985 P-------------HGCVGIMVTQSTSTSGDSKLFSTRCETGTQTYGMSNAAYCARVPDVCPP 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395	60/223 (27%)
		DUF4758	7172..7383	CDD:292572	5/26 (19%)
		DUF4696	7330..7964	CDD:292395	178/673 (26%)
		DUF4758	7400..7587	CDD:292572	61/197 (31%)
		DUF4758	7538..7707	CDD:292572	69/188 (37%)
		DUF4758	7798..7979	CDD:292572	40/225 (18%)
		DUF4758	7946..8126	CDD:292572	44/189 (23%)
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
clec-223	NP_505863.2	CLECT	856..1012	CDD:214480	28/168 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000