DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and mec-9

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_001256153.1	Gene:	mec-9 / 179382	WormBaseID:	WBGene00003173	Length:	838	Species:	Caenorhabditis elegans

Alignment Length:	656	Identity:	170/656 - (25%)
Similarity:	237/656 - (36%)	Gaps:	224/656 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 FYLNLENG------YFGCQVNESTEYLQLFNLSKLCDGTQDCFLGADELSKELKCTNDCDKDGTK 103
            ::.|.|:|      |:||..|:: ::..|....|:|         .:.||.::.| :.||...:.
Worm   119 YFFNQESGECEKFFYYGCGGNDN-KFYSLHMCRKVC---------GERLSPQIAC-DHCDLRTSF 172

  Fly   104 CTHGACLNGVCHCNDG-----YGGCNCVDKDENECKQRPCDVFAHCTNTLGSFTCTCFPGYRGNG 163
            |...:..|..|.|..|     ||  .|:|.||....:..||..|.|.|.:||:.|.|...|||:|
Worm   173 CKSNSKFNYTCECRSGYEKNQYG--ECIDIDECRGYKAVCDRNAWCVNEIGSYKCECMASYRGDG 235

  Fly   164 FHCEDID------ECQDPAIAARCVENAECCNLPAHFLCKCKDGYEGDGEVLCTDVDEC-RNPEN 221
            .||..:.      :|:|      |..:|.|.|    .:|:||:|||||| ..||||:|| |.||.
Worm   236 KHCTYVGLGRSSIDCKD------CSMHATCMN----GVCQCKEGYEGDG-FNCTDVNECLRRPEM 289

  Fly   222 CGPNALCTNTPGNYTCSCPDGYVGNNPY-----REGCQDVDECSYPNVCG------------PGA 269
            |..||.|.|..|::.|:|.:||.||. |     :..|.|..:..|.:.||            ...
Worm   290 CNKNAECINREGSFICTCLEGYAGNG-YNCTVSKNSCLDKFDHDYKDTCGNENWRPHFFFNHQTR 353

  Fly   270 ICTNLEGSYRCDCPPGYDG-DGRSESGCVDQDECARTPCGRNADCLNTDGSFRC-LCPDGYSGDP 332
            :|...          .||| .|||.:...:.|.|...       |..|:...|. :|.|.:..:.
Worm   354 MCEQF----------WYDGCRGRSRNIFSEYDTCTTM-------CEETNVLTRAEVCWDKFDMNY 401

  Fly   333 MNGCEDVDECATNNPCGLGAECVNLGGSFQ-------------------CRCPSGFVLEHDPHAD 378
            .|.|                    :.|.:|                   ||..|..:.:.:....
Worm   402 RNQC--------------------MNGQWQQRYYFDHASLTCRQFWFDGCRSDSRNIFDDELTCQ 446

  Fly   379 QL--PQPLNTQQLGYGPGATDIAPYQRTSGAGLACL-DID-----ECNQ---------PDGVAKC 426
            .|  .||:                |:..|     || |.|     |||.         ..|..||
Worm   447 WLCESQPM----------------YKSRS-----CLEDFDEGLKKECNGGRWRHQWYFDKGSKKC 490

  Fly   427 ---------GTNAKCINFPGSYRCL--CPSGFQGQ-----------------GYLHCENINE-C- 461
                     |.|...  |.....||  |.:..:..                 |.::..|:.: |
Worm   491 FSFWYDGCKGANENI--FQDELSCLHTCENPAKKDPKKPWHNNDKFKMKEIIGDIYKPNLTDTCL 553

  Fly   462 QDNPCGENAIC-----TDTVGSFVCTCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCE------ 515
            ..|||..|..|     .||   ..|.|:|.:.|:.....||.|.|.  :|||...|.|:
Worm   554 AKNPCKNNGTCIFVWKKDT---HYCKCQPGFHGNNCDKVVDYDPCA--EKPCLNGATCQIKYNDD 613

  Fly   516 --NTVPGYNCKCPQGYDGKPDPKVACEQVDVNILCSSNFDCTNNAECIENQ------CFCLDGFE 572
              :..|.:.|.|..|:.|   ||  |:|..    |.|| .|.||..|...:      |.|.:||.
Worm   614 DVDEKPTFECFCAAGFGG---PK--CDQRP----CESN-PCLNNGTCRTTKGYSTYFCECANGFG 668

  Fly   573 PIGSSC 578
              |.:|
Worm   669 --GKNC 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699	13/28 (46%)
		EGF_CA	212..247	CDD:238011	18/35 (51%)
		EGF_CA	255..>286	CDD:214542	5/42 (12%)
		EGF_CA	298..331	CDD:238011	7/33 (21%)
		EGF_CA	338..373	CDD:238011	5/53 (9%)
		EGF_CA	413..456	CDD:238011	15/84 (18%)
		EGF_CA	457..490	CDD:238011	12/39 (31%)
		EGF_CA	497..>529	CDD:214542	11/39 (28%)
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
mec-9	NP_001256153.1	Kunitz_BPTI	35..87	CDD:278443
		Kunitz_BPTI	100..154	CDD:278443	10/44 (23%)
		EGF_CA	199..238	CDD:284955	16/38 (42%)
		EGF_3	283..318	CDD:289699	17/35 (49%)
		KU	323..381	CDD:197529	14/74 (19%)
		KU	<408..449	CDD:197529	5/40 (13%)
		KU	460..516	CDD:197529	15/57 (26%)
		EGF_CA	550..586	CDD:238011	12/38 (32%)
		EGF	639..671	CDD:278437	12/34 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7818
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000