DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and dpy-1

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001370799.1 Gene:dpy-1 / 175342 WormBaseID:WBGene00001063 Length:1427 Species:Caenorhabditis elegans


Alignment Length:1700 Identity:347/1700 - (20%)
Similarity:532/1700 - (31%) Gaps:523/1700 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  6863 SDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTEQTT------SSP 6921
            |.||.::   ||..|||....|||...|...|::           :.|.|...:.:      |.|
 Worm    23 SSQTYDA---VPIGRPFLRPPPSPRQEEAPAPTL-----------ARGYQPPPRPSNFQPPRSYP 73

  Fly  6922 SEVRTTIGLEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSDQTTESTRDVPTTRP------ 6980
            |..:.::.|:....|. :..|...:.:.:.......|    |......:..|.:|.|.|      
 Worm    74 SFRQPSLNLDNRQFPG-NHQRAGQNFNWQMQQLQQQD----PQRFGFRQQQRTIPQTPPSFQPPH 133

  Fly  6981 --FEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVR---------TTIRVE- 7033
              |.|..|.....:....:........:|   |...:..||..||:::|         ..|.:. 
 Worm   134 NHFRAGAPGQIPHQGRQVAHFQRPHIQIP---TSSILQRQTEVSPADIRNGPQQLDPVNNIIIHL 195

  Fly  7034 ----ESTLPSRSTDRT---------TPSESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFEA 7085
                :..:||.:..:|         |....|.|            |||       .:..|:.|:.
 Worm   196 YLNAKDRMPSHTEIKTPVRGLFGIGTSHGGPGT------------HSD-------PIVITKDFDR 241

  Fly  7086 STPRPVTLQTAVLPVTSETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPS 7150
            .|          |....|           |||.:...|:..||:.|:     :.|:|..:.|.  
 Worm   242 DT----------LEFVDE-----------GQVQKPGASNIIEVKATV-----STPNRQLENTV-- 278

  Fly  7151 ESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQP-FESSTPRPVTLETAVPPVTSETTTNVPIGS 7214
                             ::....|.:|.:|.... ...||   :|::..:.....|...: .:..
 Worm   279 -----------------NNAVNKELNRAIPKVMDRMRGST---MTMDNGMRKELEEALVD-ELAK 322

  Fly  7215 TGGQVTEQTTPSPSEVRTTIR--IEESTFPSRSTDRTTPSESPET----PTTLPSDFTTRPH--- 7270
            ..|:..:.|..:..::...|.  .:|.....:.|..||.:::|.|    |||.....|::|.   
 Worm   323 NLGETIDNTDITEEDLEKLIEEGFDEVRKIDQETTTTTTTKAPPTTRTPPTTRTPPTTSQPAEFN 387

  Fly  7271 -SDQTTESTRDVPTTRPFESSTPRPVTLEIAVPPVTSETTTNVAIGSTGGQVTEQTTSSPSEVRT 7334
             .|...||:.|:.     ||.|..|........|.|:.||..|.:     .||..||::|....|
 Worm   388 IDDDDYESSEDIS-----ESHTTPPTQTPPTQTPPTTTTTRRVTV-----VVTSPTTTTPRRTIT 442

  Fly  7335 TIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPT--TRPFEASTPSPA 7397
            | |:..:|     |.:..|:|:|  ||..|          .||::|   ||  |||         
 Worm   443 T-RIWTTT-----TTQAPPTEAP--PTEAP----------PTTQTT---PTSWTRP--------- 477

  Fly  7398 SLETTVPSVTLETTTSVPMGSTGGQVTGQTTAPPSEVRTTIRVEESTLPSRSTDRTPPSESPETP 7462
                                 |.|:|         .|...|||.| |.|   |.:|||..:...|
 Worm   478 ---------------------TDGRV---------HVMPGIRVTE-TPP---TIQTPPPTTQTPP 508

  Fly  7463 TTLPSDFTTRPHSDQT-------TESSRDVPTTQPFESSTP---RPVTLEIAVPPVTSETTTNVP 7517
            ||..|..|..|.:.||       |.::|..|.|......||   ||.|..:...|.:.|      
 Worm   509 TTQTSSTTQTPRTKQTWAPWTPPTTTTRQTPPTTQAPPITPPPYRPPTSVVTYGPESEE------ 567

  Fly  7518 IGSTGGQVTGQTTATPSEVRTTIGVEEST--------LPSRSTD-RTTPSESP----ETPTTLPS 7569
            |........||.:|.|:...|.|.|..||        |.|...| .:|.:..|    .|.:|:..
 Worm   568 IQHAEHAENGQISAIPTRKPTLIEVSPSTHHHHGIVNLESNEEDYESTVTSKPVIMFTTESTVVH 632

  Fly  7570 DFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLET-------TVPSVTLETTTNVPIGSTGGQV 7627
            :..|:|.|         .||..|...|.|...|.|.       |.|:.|:...|:.|  ||..:.
 Worm   633 NLPTKPSS---------APTLHPSTFSPPLVTSSENPFTFTLDTTPTSTVTPMTSPP--STVTET 686

  Fly  7628 TGQTTATPSEVRTTIGVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTT 7692
            |..:|.||........|:....|     .|..:|.|...|   |.....|.:.....|:..||||
 Worm   687 TPTSTVTPRRYTVDEIVKIEVAP-----HTIYTEEPFFST---SSIEWNPITSAEDYSSPTVPTT 743

  Fly  7693 RPFEASTPRPV--------TLETAVPSVTSETTTNVPIGSTVTSETTTNVPIGSTGGQVAGQTTA 7749
                ..||..|        |.|.|:|:....|||...|.||..|||:......|:..::......
 Worm   744 ----TVTPEVVREDEDYDYTNEFAIPNEPIVTTTTTAIASTTNSETSKPRHQSSSSEEIQPNFVI 804

  Fly  7750 PPSEVRTTIRVE------ESTLPSRSADRTTPSESP-------ETPTTLPS-------------- 7787
            |.....|..|.|      :......|:|..|..:..       ||.....:              
 Worm   805 PSGACPTPNRPEIDRNRTDILFLLDSSDNFTEQKFQRAIKLIGETVGQFSNFGADGVQVSLVQYN 869

  Fly  7788 -----DFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLET------TVPSVTSETTTNVPIGST 7841
                 :|:.|.|:.: .....|:..|......:....:||.      |..........|:.|..|
 Worm   870 DEPYLEFSLRKHNCK-KHLLADIADTEFMTGGSQLNKALEKVSQFAFTKKRGDRPDAENILIIVT 933

  Fly  7842 GGQLTEQSTSSPSE----------VRTTIRVEESTLPSRSTDRTFPSE----------------- 7879
            .|| ::.....|:.          |.:|:..:::.:.:.|.:..:.|:                 
 Worm   934 DGQ-SDARIQEPTRLVKDHNVTVLVISTLEADKNFIINLSAENLYDSDNFGKDLAWKLAKRISDS 997

  Fly  7880 SPEKPTTLPSD----FTTRPHL-EQTTESTRDVLTTRPFETSTPSPVSLETTVPSVTSETSTNVP 7939
            ||:.....|.:    ....|.| |...||...::||||....              |:|.|..:.
 Worm   998 SPKYSVKNPENSKILTPVLPDLNENLAESPEVLVTTRPENAE--------------TAENSGIID 1048

  Fly  7940 IGSTGGQVTEQTTAPPSVRTTETIVKSTHPAVSPDTTIPSEIPATRVPLESTTRLYTDQTIPPGS 8004
            :...|.....|...|...|.. .:||..........|..|.:|         ..|:         
 Worm  1049 LECVGDGFKVQVNPPAGFRGV-AVVKGYQDDARCKATASSSLP---------LNLF--------- 1094

  Fly  8005 TDRTTSSERPDESTRLTSEESTETTRPVPTVSPRDALETTVTSLITETTKTTSGGTPRGQVTERT 8069
                           :::.|...|  .|.:..|.....:.|..|:.:                  
 Worm  1095 ---------------ISNNECGVT--QVKSSDPNGLNSSLVLHLLHD------------------ 1124

  Fly  8070 TKSVSELTTGRSSDVVTERTMPSNISSTTTVFNNSEPVSDNL---PTTISITVTDSPTTVPVPTC 8131
                .||.|......:.:..:.:.        |....||.||   .:.::|..|.|.:|:| |||
 Worm  1125 ----DELNTAEDRAYLLQCFIGAQ--------NQDAVVSTNLNVVRSELAIAETISLSTLP-PTC 1176

  Fly  8132 KTDYDCLDE-------QTCIGGQCISPCEYFTNLCTVQNLTICRTLNHTTKCY------CDTDDD 8183
              .|....|       ...:.||            ||.:...|...|.|.:.|      |...||
 Worm  1177 --TYSIRKEGPEGPIVSRAVVGQ------------TVWHRWECDGTNDTNQAYGIQVHSCYASDD 1227

  Fly  8184 VNRPDCSMKAEIGCASSDECPSQQACINALCVDPCTFNNPCSRNEDCRVFN-HQ----------P 8237
            |.|....:... ||:|.          .||..|....::..:......||| |.          .
 Worm  1228 VERKFAFVDPR-GCSSD----------LALLTDLTYADDSLTAWAASHVFNVHDAESLKFVCKLS 1281

  Fly  8238 LCSAEHGRTPGCEHCPPGANCDPTTGACIKANVTITTITTKNSTS------TKIPTKPRTTANPN 8296
            ||:.:   ..|||...|     |..|...|..:.:|....|...|      :.:.|..:.|:..:
 Worm  1282 LCTRD---GDGCEGVTP-----PACGNTNKTGLLLTKRLAKGINSVDEALTSALSTNVKLTSGSS 1338

  Fly  8297 TGVK---TTPTTT-----------------RVTTRNTTTTTTTTTTSS---TSTESSTITSATNQ 8338
            .|::   .:.|::                 .:.:||....:.|.||.|   |.:||.....:...
 Worm  1339 DGLEDLLKSATSSYLFWVVALVAVAAIVAISILSRNMAENSDTATTCSDPTTMSESQDFGGSIRS 1403

  Fly  8339 TSKNQKPDTE 8348
            .|....|:.:
 Worm  1404 ISSPPPPNRQ 1413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395 30/149 (20%)
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572 20/83 (24%)
DUF4758 6866..7045 CDD:292572 38/206 (18%)
DUF4758 6968..7179 CDD:292572 41/241 (17%)
DUF4696 7024..7569 CDD:292395 134/603 (22%)
DUF4758 7172..7383 CDD:292572 53/221 (24%)
DUF4696 7330..7964 CDD:292395 166/743 (22%)
DUF4758 7400..7587 CDD:292572 53/209 (25%)
DUF4758 7538..7707 CDD:292572 50/196 (26%)
DUF4758 7798..7979 CDD:292572 37/218 (17%)
DUF4758 7946..8126 CDD:292572 26/182 (14%)
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
dpy-1NP_001370799.1 VWA 823..975 CDD:395045 22/153 (14%)
Zona_pellucida 1050..1299 CDD:421542 64/348 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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