DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and cutl-9

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_496293.2	Gene:	cutl-9 / 174640	WormBaseID:	WBGene00010893	Length:	562	Species:	Caenorhabditis elegans

Alignment Length:	516	Identity:	110/516 - (21%)
Similarity:	175/516 - (33%)	Gaps:	131/516 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly 22499 PECT---------SNDQCADNRFCNLDTKTCE---DPCLTKVCGVNAFCNAVNHRAQCQCITGYT 22551
            |:||         |.....|..|....||:.|   :..|....|.:.  :.::::.|.|..|..|
Worm    71 PQCTKTFRNGVASSGGHIEDETFLGTVTKSREPYVEDHLKASRGSSD--SKISNQYQNQKATSNT 133

  Fly 22552 -------GNPDL-------HCNHTNFRTD------FPRPDMVVSCLADGVQVEIHITEPGFNGVL 22596
                   ...||       |.|..|...|      .||.:...|...:|....|.....|.|.:.
Worm   134 NFEHASKSGTDLGTKSKTFHENDINSAPDIAETFLLPRKNETTSDTDEGEWKGIGGASAGGNAIF 198

  Fly 22597 YVKGHSKDEECR---------RVVNLAGETVP-----------------------RTE------I 22623
               |.::.||.|         ...:..|.|:|                       ||.      .
Worm   199 ---GGTRGEELRVFGKSVTSSSTRSRPGSTLPLSTSSSPDCPPLTTCAPCACEERRTRRATNSIR 260

  Fly 22624 FRVHFGSCGMQAVKD------VASFVLVIQKHPKLVTYKAQAYNIKCVYQTGEKNVTLGFNVSML 22682
            ..|...||..:..:.      |.|.:.|:..|...:|...:||:|:|.|...||.|:...:|:|
Worm   261 LEVPLNSCNTKRDRKLNPPSVVVSLIAVVSFHDSFITKLDKAYHIQCAYAEAEKTVSTDLDVNM- 324

  Fly 22683 TTAGTIANTGPPPICQMRIITNEGEEINSAEIGDNLKLQVDVEPATIYGG-------FARSCIAK 22740
            |....|..|..||.|...|....|..:.::.:|:.::.|     ....||       ....|..|
Worm   325 TDEQEINGTVEPPSCDYLISDQNGNSVQNSLVGELVRHQ-----WVCKGGLTNKLKMLVHQCYVK 384

  Fly 22741 TMEDNVQNEYLVTDENGCATDTSIFGNWEYNPDTNSLLASFNAFKFPSSDNIRFQCNIRVCF--- 22802
               |....::.|.|::||..|..:.....|:.|..|.......||||....:.|:|.|..|.
Worm   385 ---DGAGQQFEVIDQHGCTLDQLMLQTPTYSEDGMSAQVDAYIFKFPDRSTVDFRCTITFCSVDD 446

  Fly 22803 GRC---QPVNCGGYNAFGRRRRSIADNSTDATAIATNSGVEGQLREEITISSNAILTFEKRSGQG 22864
            ..|   .|..||..|...||::            .::.|:     ..:::.:|::..|:..|.:
Worm   447 AECLDMTPPKCGANNNLLRRKK------------RSSHGL-----SSMSLHANSLTVFDIDSSK- 493

  Fly 22865 LNDAN---IKPAAQR------VEDICVSMVGLIIALVITALLALVAVAVAVSCWLMAYRRR 22916
             .|.|   ..||..|      ....|||:....|.:..:...|.:::||..|.:.:.:..:
Worm   494 -TDTNQLLPTPALLRKTFEEYERTFCVSVASFGILISASTFFATISIAVIFSYFFLRFNHK 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579	64/291 (22%)
		Zona_pellucida	<22714..22810	CDD:278526	25/108 (23%)
cutl-9	NP_496293.2	ZP	244..460	CDD:214579	55/224 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910