DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and lec-2

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001379091.1 Gene:lec-2 / 174560 WormBaseID:WBGene00002265 Length:1245 Species:Caenorhabditis elegans


Alignment Length:1241 Identity:244/1241 - (19%)
Similarity:399/1241 - (32%) Gaps:381/1241 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  4473 RPHSEKTTESTRDVPTTRPFEASTPSSASL---------------ETTV-----------PSVTL 4511
            :|....|....:|...:...||...:||::               :|.|           .:|..
 Worm    28 KPVDADTASDAKDAKDSAIQEAVQNASAAINDVFTDAVDKLEEVKDTVVEQFSNGDEKKEEAVVE 92

  Fly  4512 ETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTLSESPETPTTLPSDFTIRP 4576
            |...:|.:|..|....::......|.:..::       ...||.|.:.|.       .:|....|
 Worm    93 EKFDSVHVGVDGETAVQEAKEEVKEAQVVVK-------GVLADGTQIVEG-------VTDVAEAP 143

  Fly  4577 HSEQTTESTRDVPTTRPFEASTP-------SPASLETTVPSVTSETTTNVP---------IGSTG 4625
            .:::..|.|    ...|.:::.|       |.:|..|..|:.|.::.....         :.:.|
 Worm   144 VADEKKEET----VAAPLDSAAPVEEHKEESHSSEHTEAPAHTEDSIVQADPEARIVFQGVLADG 204

  Fly  4626 GQVTGQTTA-PPSEFRTTIRVEESTLPSRSTDRTTPSESPETPTILPSDSTTRTYSDQTTESTRD 4689
            .|:....:| ||.       ::|.:.|:.:..    .|..|...::|.|...            :
 Worm   205 TQIIEAVSANPPC-------IQEESAPAAAVS----EEVGEAVHVVPVDQAP------------E 246

  Fly  4690 VPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGSTGGQVT----EQT---TSSPSEVRTTIRV 4747
            .||:   ||...:|  :|..|..|.:....:.|..:...:.|    |||   .:||::  ..::|
 Worm   247 APTS---EAQDAAP--IEEHVEVVHVAENASTPAATDAHEETKSAEEQTPVVDASPAQ--EIVKV 304

  Fly  4748 EESTLPSRSA-DRTTP-----SESPETPTTLPSDFITRPH---SEKTTE----------STRDVP 4793
            ||......:| |.:.|     |...||...:..:.|...|   :|...|          ::.|..
 Worm   305 EEHEHKEEAAPDESAPEAAHDSHVEETAAQVVDEVIEAVHVSANESAPEEHKEEVAAAATSEDQK 369

  Fly  4794 TTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSS--------PSEVRTTIRVE 4850
            ...|......|.:::|..:.||.:..|.:.|:.|     .|.||.:        .:||...:...
 Worm   370 EPAPASDEHTSESAVEGAIESVHIALTESAPVAS-----DENTTEAAPGTVEEHKNEVHDPVDGA 429

  Fly  4851 ESTLPSRS-ADRTTPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEASTPSSASLETTV 4914
            .|..|:.. .:....|||.|.|       ||..|.|.|             |::.|:....|.|.
 Worm   430 SSDAPAEDHREAAASSESVEEP-------ITAVHVEAT-------------ESAAPADKVHEETK 474

  Fly  4915 PSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTP-SESPETPTTLPS 4978
            .....||..:.|:          ..:||:|                 |:.:. :|:|...:...:
 Worm   475 IDSAAETHADAPV----------VDASPAE-----------------DQASEVTEAPHVESAKSA 512

  Fly  4979 DFTTRPHSEQTTESTRD-VPTTRPF-----EASTPSPASLETTVPSVTLETTTNVPIGSTGGQVT 5037
            ..|:..|.|...::|.: |.|..|.     :||...|.:::..:.::.:.:|.:.|         
 Worm   513 PATSEDHKEDVAQATSEQVETQAPADEHKDDASPAEPTTVQDVIEAIPIVSTESTP--------- 568

  Fly  5038 EQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFITRTYSDQT--TESTRDVPT 5100
                                     |:.:.|:||        :..:...:.|:.  :|..:|||.
 Worm   569 -------------------------AEHSAPAES--------APALAEEHKDEAAPSEPVQDVPV 600

  Fly  5101 TRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEFRTTIRVEESTLPSRST 5165
            ....||...:||.                             :||.|       |||:       
 Worm   601 EEVIEAVHIAPAE-----------------------------SAPAS-------VEEA------- 622

  Fly  5166 DRTTPSESPETPTTLPSDFTT---RPHSDQTTESTRDVPT-----TRPF-----EASTPSPASLE 5217
               .||||.:.|.....|.||   ..|.:...||  |.|.     |.|.     |||..:..|:|
 Worm   623 ---APSESTQAPVEEHKDATTAADSSHEEPKAES--DAPAAESVETAPVEEHKDEASPTALESVE 682

  Fly  5218 TTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSE-------- 5274
            ..:.:|.:.:|.:.|.........:.|.:...|.:.|....|.:.....||.....|        
 Worm   683 DVIEAVHVASTESAPAPVEDAASADSTQAPVEEQKDTAAAAEPSHEEAQADHAASVEDVIEAVHI 747

  Fly  5275 -----SPETPTLPSD------------FTTRP-HSEQTT--ESTRDVPATRPFEASTPSPASLET 5319
                 :|.|...||:            .|..| |.|..|  |::...|..   |::.|...::|:
 Worm   748 ASNESAPTTEAAPSESIQAEDHKDEAASTAEPAHEESVTVVEASHKEPQA---ESAAPVEENIES 809

  Fly  5320 TVPSVTSEATTNVPIGSTGGQVTEQTTSSP-SEVRTTIRVEESTLPSRSTDRTSPSE-------- 5375
            .  .|.||.:...|.|......:...:.:| .||.....||  ::.|..||..|..|        
 Worm   810 V--HVASEESAPAPSGDAAPSESAPVSENPVEEVAVAYHVE--SIESVPTDAQSVEEPVVQQHVG 870

  Fly  5376 ----SPETPTTLPSDFTTRPHSDQTTECTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPI 5436
                :||......|......|||          ...| |.:||.|.| |.|...|........| 
 Worm   871 TVEAAPEAAVDEESFDVVHVHSD----------AAHP-ETATPESGS-EETFEKVEHSQVQEAP- 922

  Fly  5437 GSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTEST 5501
                  .:|:..||..|:...:..::......||..|.|.|||:.|        |..:|...||.
 Worm   923 ------SSEEHNSSEPEIVEDVVEKQIVAAVASAPETQPEESPKKP--------RKLAEMAHESA 973

  Fly  5502 RDVP----TTRPFEASTPSSASLETTVPSV--TLETTTNVPIGSTGGQVTEQTTSSPSEFRTTIR 5560
            ..||    ...|||.........:|...|:  |:...||          |...:.:......::|
 Worm   974 FPVPYRSKLVEPFEPGQTLIVKGKTGEDSIRFTVNLHTN----------TADFSGNDVPLHVSVR 1028

  Fly  5561 VEESTL 5566
            .:|..|
 Worm  1029 FDEGKL 1034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395 41/247 (17%)
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572 20/126 (16%)
DUF4758 4581..4754 CDD:292572 38/196 (19%)
DUF4758 4683..4847 CDD:292572 42/197 (21%)
DUF4758 4785..4964 CDD:292572 38/197 (19%)
DUF4696 4841..5385 CDD:292395 119/607 (20%)
DUF4758 4887..5098 CDD:292572 32/219 (15%)
DUF4758 5193..5371 CDD:292572 48/216 (22%)
DUF4758 5294..5487 CDD:292572 49/207 (24%)
DUF4758 5445..5650 CDD:292572 30/128 (23%)
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
lec-2NP_001379091.1 rne <136..298 CDD:236766 36/193 (19%)
PRK14949 <235..662 CDD:237863 113/587 (19%)
rne <474..771 CDD:236766 74/413 (18%)
rne <794..963 CDD:236766 47/202 (23%)
GLECT 978..1108 CDD:214596 12/67 (18%)
GLECT 1116..1243 CDD:238025
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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