DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and cutl-15

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_495904.2	Gene:	cutl-15 / 174426	WormBaseID:	WBGene00011888	Length:	385	Species:	Caenorhabditis elegans

Alignment Length:	415	Identity:	91/415 - (21%)
Similarity:	159/415 - (38%)	Gaps:	81/415 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly 22546 CITGYTGNPDLHCNHTNFRTDFPRP------DMVVSCLADGVQVEIHITEPGFNGVLYVKGHSKD 22604
            |..|    |.:.|     :.:.|.|      :..|||.||.:.|::. |:..|.|.:.|| :|.|
Worm    14 CFDG----PGIKC-----QDEEPTPRNEVLGEPTVSCAADAIYVKLR-TKSTFLGHVDVK-YSPD 67

  Fly 22605 EECRR--VVNLAGE-TVPRTEIFRVHFGSCGMQAVKDVASFVLVIQKHPKLVTYKAQAYNIKCVY 22666
            :.|.:  |.|...| .:|..|.......|.....|  :....|.:..||:..|...:.:|::|.:
Worm    68 KACFQSLVTNNQIEILIPHEECMVPRRRSLHPTGV--ILEVSLSVSFHPEFTTVDDRIFNMQCFH 130

  Fly 22667 QTGEKNVTLGFNVSMLTTAGTIANTGPP------PICQMRIITNEGEEINSAEIGDNLKLQVDVE 22725
            |.         .::..:|:..|.:..||      |.|...::|:.|    ....| .|.|..||.
Worm   131 QK---------KINGTSTSLAIGSPKPPPSDTKGPSCSYEVLTSPG----GLPAG-RLALGQDVY 181

  Fly 22726 PATIYGGFARSCIAKTMEDNV-----QNEYLVTDENGCATDTSIFGNWEYNPDTNSLLASFNAFK 22785
            .:........|||   |.:|.     :..:.|.|.:||:...||....||:..|: :..|...|.
Worm   182 HSWQCQNVYESCI---MIENCELVGGEETHEVIDSSGCSKHESIMPQLEYHNRTH-VGTSVKVFG 242

  Fly 22786 FPSSDNIRFQCNIR----VCFGRCQPVNCGGYNAFGRRRRSIADNSTDATAIATNSGVEGQLREE 22846
            ...:..:.|.|.:|    :..|.|....|.    ..||:|.  |:|...:....:..:|  :.:.
Worm   243 VSHTSIVYFACQVRLHPQLPTGECPKPKCD----LMRRKRE--DSSQFPSIDVRSQNLE--ISQL 299

  Fly 22847 ITISSNAILTFEKR------------SGQGLNDANIKPAAQRVEDICVSMVG-LIIALVITALLA 22898
            |.|:|:.:......            ..:.:.:|:...|... |.||..... |::::::|..|.
Worm   300 INITSSTMTPHPTEPPIQHTCPDIHVETESIEEASESKALDE-ERICADFRSVLVVSILLTVALI 363

  Fly 22899 LVAVAVAVSCWLMAYRRRPKTIAPL 22923
            |:...:.:    :..||:...||.:
Worm   364 LITTTIVI----LIVRRQKYEIASM 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579	60/252 (24%)
		Zona_pellucida	<22714..22810	CDD:278526	26/104 (25%)
cutl-15	NP_495904.2	ZP	41..272	CDD:214579	60/252 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910