DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and npp-11

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	NP_491232.1	Gene:	npp-11 / 171954	WormBaseID:	WBGene00003797	Length:	805	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	167/710 - (23%)
Similarity:	247/710 - (34%)	Gaps:	176/710 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  5582 TPTLPSDFTTRPHSEQTTESTRDVPTTRPFE--ASTPSPASL-----ETTVPSVTSETTTNVPIG 5639
            |.|..|.|:....|..|..:..:..||..|.  ::.||..|.     .|...|:...::...|..
Worm    18 TTTASSGFSFGNSSTSTANTGGNTNTTGGFSFGSAQPSTGSTGLFGNSTATGSMFGGSSAAAPAP 82

  Fly  5640 STGGQVTGQTTAPPSEVRTTI--RVEESTLPSRST-DRTTPS--------ESPETPT--ILPSDS 5691
            ::.|.......|.|:...|:|  ....|..|:..| ..:.||        ..|..||  :..|.:
Worm    83 ASAGIFGNSGAAAPAPASTSIFGSSANSAAPATVTFGASAPSAGAGMFGANKPAAPTGGLFGSST 147

  Fly  5692 TTRTYSDQTTESTRDVPTTRPFEASTPSPAS---LETTVPSV------TLETTTNVPIGSTGGQV 5747
            :|.|          ..||...|.:||.:|:|   ..|..|:.      :..|:|..|.|...|..
Worm   148 STAT----------TAPTGGLFGSSTAAPSSGLFGSTAAPAAPGGLFGSTSTSTAAPSGGLFGSS 202

  Fly  5748 TGQTTATPSEVRTTIGVEESTLPSRSTDRTSPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTT 5812
            ...|:..|:......|...:|..:..|.....:.:|....:....|...|
Worm   203 AAPTSTAPAPSGGLFGAAPATSNAAPTSGLFGNSAPAATASSGGLFGAAP--------------- 252

  Fly  5813 RPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTEQTTSSPSEVRTTIGL-EESTLPSRST 5876
               :.:.||.....:|.|:.|:.|||     :|.| :....||:||....|.|| ..||.|:.:|
Worm   253 ---KPAAPSGGLFGSTAPATTAATTT-----ATSG-LFGAPTSAPSSAPATGGLFGASTAPAAAT 308

  Fly  5877 DRTSPSESPETPTTLPSDFITRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSETTTN 5941
            .......:....|  ||..:....|..||.:.  .|.|.|..|||.......|...:
Worm   309 GGLFSIGAASAST--PSVGLFGNSSASTTAAA--APATAPAAASTGGLFGATTAAAA-------- 361

  Fly  5942 VPIGSTGGQVTGQTTAPPSEVRTTIGVEESTLPSRSTDRTSPSESPETPTTLPSDFITRPHSEQT 6006
            .|..||.|.:.|.|.|.|:....|.|:..|         ::|:::|..||.    .:....|..|
Worm   362 APTSSTTGGLFGSTAAAPAASLPTGGLFGS---------STPAKTPAAPTA----GLFGASSTTT 413

  Fly  6007 TESTRDVPTTRPFEASTPSPASLKTTVPSVTSEATTNVPIGSTGQRIG----TTPSESPETPTTL 6067
            |              |.|:..||..|.|:.|: ||:..|..|||...|    |||:.:..|....
Worm   414 T--------------SAPATGSLFGTAPATTT-ATSAAPAASTGGLFGASSTTTPASTAPTGGLF 463

  Fly  6068 PSDFTTRPHSEKTTESTRDVPTTRPFETSTPSPASLETTVPSVTLETTTNVPIGSTGGQVTEQTT 6132
            .:..||.|.:.        .||...|..:|       ||.|:.         :|.|||.....||
Worm   464 GAATTTAPAAA--------APTGGLFGAAT-------TTAPAT---------VGPTGGLFGAATT 504

  Fly  6133 SSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRDVPTTRPFEA- 6196
            ::|:...|.              ..|||....||:||:          ||.:|..:|  :|.||
Worm   505 TTPATAATL--------------GQTPSTVSATPSLPT----------TTSTTSTLP--KPAEAT 543

  Fly  6197 ----------STPSPASLETTVPSVTSETTTN--VPIGSTGGQVTGQTTAPPSEVRTTIG 6244
                      |||.......|...:....||:  :.||::|..     |....|::..:|
Worm   544 PTLGLGLGLTSTPLAKGTGWTTSGLKGAATTSAGLKIGASGSD-----TLSEEEIKAGLG 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572
		DUF4758	4785..4964	CDD:292572
		DUF4696	4841..5385	CDD:292395
		DUF4758	4887..5098	CDD:292572
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572	16/74 (22%)
		DUF4758	5700..5877	CDD:292572	42/186 (23%)
		DUF4696	5756..6396	CDD:292395	120/507 (24%)
		DUF4758	5802..5979	CDD:292572	45/177 (25%)
		DUF4758	5964..6171	CDD:292572	53/210 (25%)
		DUF4758	6181..6360	CDD:292572	19/77 (25%)
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
npp-11	NP_491232.1	Nucleoporin_FG	117..218	CDD:290362	25/110 (23%)
npp-11	NP_491232.1	Nucleoporin_FG	220..328	CDD:290362	29/133 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910